The role of DNA methylation in cadmium-induced anti-carcinogenesis
Project/Area Number |
19590131
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Environmental pharmacy
|
Research Institution | Hiroshima International University |
Principal Investigator |
TAKIGUCHI Masufumi Hiroshima International University, 薬学部, 准教授 (90330753)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | カドミウム / エピジェネティックス / がん / DNA / メチル化 / 抗がん / MMP / メタロチオネイン / DNAメチル化 / エピジェネティック / DNAメチル化酵素 / 亜鉛 |
Research Abstract |
Cadmium (Cd) is a carcinogenic metal in humans and rodents. Cd in certain instances can also be anti-carcinogenic. In this study, Cd is an effective inhibitor of DNA methyltransferase, controlled DNA methylation status, and kinetic studies indicated the mechanism is via interference with enzyme-DNA interaction. The enzyme-DNA binding site may be Pro-Cys in catalytic site of enzyme. In addition, Cd inhibited cell invasion activity via inhibition of MMP2 activity. This result proposed one of the new mechanisms of cadmium-induced anti-carcinogenesis.
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Report
(5 results)
Research Products
(10 results)