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Hyperesthesia via the alteration of thermo-sensitive TRP channels in animal model of irritable bowel syndrome

Research Project

Project/Area Number 19590156
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionJosai International University

Principal Investigator

HORIE Syunji  Josai International University, 薬学部, 教授 (50209285)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
KeywordsTRPV1 / カプサイシン / TRPA1 / アリルイソチオシアネート / 下部消化管 / 内臓知覚神経 / 免疫組織化学 / ストレス / 消化管機能 / CGRP / 知覚過敏 / TRPVJ / TRPAJ / 内臟知覚神経
Research Abstract

精神的ストレスが積み重なると、消化管に大きな影響を与え、便通異常と痛みを伴う過敏性腸症候群というやっかいな病気に進展する。この原因を解明するために、過敏性腸症候群モデル動物を用いた研究を行った。結果として、ストレスにより消化管に知覚過敏が引き起こされており、これにはカプサイシン受容体TRPV1(43℃の熱で活性化するセンサー)の反応性が大きくなっていることが判明した。したがって、このカプサイシン受容体は新しい医薬品のターゲットになると考えている。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (47 results)

All 2009 2008 2007

All Journal Article (22 results) (of which Peer Reviewed: 20 results) Presentation (25 results)

  • [Journal Article] Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon.2009

    • Author(s)
      Matsumoto, K., Kurosawa, E., Terui, H., Hosoya, T., Tashima, K., Murayama, T., Priestley, J.V., Horie, S.
    • Journal Title

      Am. J. Physiol. Gastrointest. Liver Physiol. (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nicotine-induced neurogenic relaxation in the mouse colon; changes with dextran sodium sulfate-induced colitis.2009

    • Author(s)
      Murakami I., Hamada Y., Yamane S., Fujino H., Horie S., Murayama T.
    • Journal Title

      J. Pharmacol. Sci. 109(1)

      Pages: 128-138

    • NAID

      10025733944

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nicotine-induced neurogenic relaxation in the mouse colon ; changes with dextran sodiumsulfate-induced colitis2009

    • Author(s)
      Murakami, I.
    • Journal Title

      J. Pharmacol. Sci. 109

      Pages: 128-138

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validation of 13C-acetic acid breath test by measuring effects of loperamide, morphine, mosapride, and itopride on gastric emptying in mice.2008

    • Author(s)
      Matsumoto, K., Kimura, H., Tashima, K., Uchida, M., Horie, S.
    • Journal Title

      Biol. Pharm. Bull. 31(10)

      Pages: 1917-1922

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Chemical Constituents of Aristolochia constricta: Antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid.2008

    • Author(s)
      Zhang, G., Shimokawa, S., Mochizuki, M., Kumamoto, T., Nakanishi, W., Watanabe, T., Ishikawa, T., Matsumoto, K., Tashima, K., Horie, S., Higuchi, Y., Dominguez, O.P.
    • Journal Title

      J. Natural Products 71

      Pages: 1167-1172

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of transient receptor potential vanilloid subtype 1 in the trachea of ovalbumin-sensitized guinea pigs.2008

    • Author(s)
      Watanabe, N., Horie, S., Spina, D., Michael, G.J., Page, C.P., Priestley, J.V.
    • Journal Title

      International Archives of Allergy and Immunology 146(1)

      Pages: 28-32

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] MGM-9 [(E)-methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate], a derivative of the indole alkaloid mitragynine: a novel dual-acting μ- and κ-opioid agonist with potent antinociceptive and weak rewarding effects in mice.2008

    • Author(s)
      Matsumoto, K., Takayama, H., Narita, M., Nakamura, A., Suzuki, M., Suzuki, T., Murayama, T., Wongseripipatana, S., Misawa, K., Kitajima, M., Tashima, K., Horie, S.
    • Journal Title

      Neuropharmacology 55(2)

      Pages: 154-165

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] トウガラシの辛味は胃でも味わう:カプサイシンのバニロイド受容体を介した胃機能への薬理作用2008

    • Author(s)
      堀江俊治
    • Journal Title

      Food and Food Ingredients Journal of Japan 213(7)

      Pages: 660-665

    • NAID

      40016179675

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 温度と辛味を感じる受容体:消化管にとってよい受容体か?悪い受容体か?2008

    • Author(s)
      堀江俊治、田嶋公人、松本健次郎
    • Journal Title

      I. Research 16(5)

      Pages: 403-410

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Validation of 13C-acetic acid breath test by measuring effects of loperamide, morphine, mosapride, and itopride on gastric emptying in mice2008

    • Author(s)
      Matsumoto, K.
    • Journal Title

      Biol. Pharm. Bull. 31

      Pages: 1917-1922

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The chemical constituents of Aristolochia constricta : antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid2008

    • Author(s)
      Zhang, G.
    • Journal Title

      J. Natural Products 71

      Pages: 1167-1172

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of transient receptor potential vanilloid subtype 1 in the trachea of ovalbumin-sensitized guinea pigs2008

    • Author(s)
      Watanabe, N.
    • Journal Title

      International Archives of Allergy and Immunology 146

      Pages: 28-32

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MGM-9[(E)-methyl 2-(3-ethyl-7a, 12a-(epoxyethanoxy)-9-fluoro-1, 2, 3, 4, 6, 7, 12, 12b- octahydro-8-methoxyindolo[2, 3-a]qulnolizin-2-yl)-3-methoxyacrylate], a derivative of the indole alkaloid mitragynine : a novel dual-acting μ-and κ-opioid agonist with potent antinociceptive and weak rewarding effects in mice2008

    • Author(s)
      Matsumoto, K.
    • Journal Title

      Neuropharmacology 55

      Pages: 154-165

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] トウガラシの辛味は胃でも味わう : カプサイシンのバニロイド受容体を介した胃機能への薬理作用2008

    • Author(s)
      堀江俊治
    • Journal Title

      Food and Food Ingredients Journal of Japan 213

      Pages: 660-665

    • NAID

      40016179675

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 温度と辛味を感じる受容体 : 消化管にとってよい受容体か? 悪い受容体か?2008

    • Author(s)
      堀江 俊治
    • Journal Title

      G. I. Research 16

      Pages: 403-410

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Immunohistochemical co-localization of transient receptor potential vanilloid subtype l in the trachea of guinea pigs sensitized by ovalbumin2008

    • Author(s)
      Watanabe, N.
    • Journal Title

      Int. Arch. Allergy Immunol. (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine. Eur.2007

    • Author(s)
      Penuelas, A, Tashima, K., Tsuchiya, S., Matsumoto, K., Nakamura, T., Horie, S., Yano, S.
    • Journal Title

      J. Pharmacol. 576(1-3)

      Pages: 143-50

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of capsaicin via TRPV1 in isolated mouse lower gastrointestinal tract and the influence of neonatal stress.2007

    • Author(s)
      Horie, S., Matsumoto, K., Tashima, K.
    • Journal Title

      Autonomic Neuroscience 135(1-2)

      Pages: 96-97

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quercetin-induced PC12 cell death accompanied by caspase-mediated DNA fragmentation.2007

    • Author(s)
      Sasaki, M., Nakamura, H., Tsuchiya, S., Horie, S., Kashiwayanagi, M., Saito, T., Murayama, T.
    • Journal Title

      Biol. Pharm. Bull. 30(4)

      Pages: 682-686

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quercetin-induced PC12 cell death accompanied by caspase-mediated DNA fragmentation2007

    • Author(s)
      Sasaki, M.
    • Journal Title

      Biol. Pharm. Bull 30

      Pages: 682-686

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contractile effect of TRPAl receptor agonists in the isoated mouse in testine2007

    • Author(s)
      Penuelas, A.
    • Journal Title

      Eur. J. Pharmacol 576

      Pages: 143-150

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NOを介する附子アルカロイド・メサコニチンの内皮依存性血管弛緩作用2007

    • Author(s)
      堀江 俊治
    • Journal Title

      薬学雑誌 127

      Pages: 79-82

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラット胃におけるバニロイド受容体TRPV1神経の分布:脳腸ペプチド カルシトニン遺伝子関連ペプチドおよびサブスタンスPとの共存2009

    • Author(s)
      堀江俊治、松本健次郎、田嶋公人
    • Organizer
      ワークショップ。第5回消化管学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] ラツト胃におけるバニロイド受容体TRPV1神経の分布 : 脳腸ペプチドかレシトニン遺伝子関連ペプチドおよびサブスタンスPとの共存2009

    • Author(s)
      堀江俊治
    • Organizer
      第5回消化管学会総会
    • Place of Presentation
      新宿
    • Related Report
      2008 Annual Research Report
  • [Presentation] ワサビ辛味成分アリルイソチオシアネー卜はTRPA1チャネル非依存性にラツト胃粘膜タイトジャンクションバリアを機能低下させる。2009

    • Author(s)
      佐藤翔吾
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス直腸におけるTRPV1発現神経と神経ペプチドの局在に関する免疫組織化学的検討2009

    • Author(s)
      松本健次郎
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] トウガラシの辛みの薬効に科学的エビデンス:胃におけるバニロイド受容体TRPV1発現神経の分布と機能2008

    • Author(s)
      堀江俊治
    • Organizer
      第7回神経消化器病学会(招聘講演)
    • Place of Presentation
      東京
    • Year and Date
      2008-09-30
    • Related Report
      2008 Final Research Report
  • [Presentation] トウガラシの辛みの薬効に科学的エビデンス : 胃におけるバニロイド受容体TRPV1発現神経の分布と機能2008

    • Author(s)
      堀江俊治
    • Organizer
      第7回神経消化器病学会
    • Place of Presentation
      本郷
    • Year and Date
      2008-09-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット培養胃粘膜細胞におけるタイトジャンクションバリアに対する温度感受性チャネルTRPV1、TRPA1作動薬の作用2008

    • Author(s)
      田嶋公人、佐藤翔吾、吉田実世、松本健次郎、村山俊彦、堀江俊治
    • Organizer
      シンポジウム。第26回Cytoprotection研究会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-14
    • Related Report
      2008 Final Research Report
  • [Presentation] マウス直腸、遠位、横行、近位結腸におけるバニロイド受容体TRPV1の局在とカプサイシン誘起平滑筋収縮の相関2008

    • Author(s)
      松本健次郎、田嶋公人、堀江俊治
    • Organizer
      第26回Cytoprotection研究会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-14
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Differences in localization of TRPV1 channels and contractile effect of capsaicin in mouse isolated lower gastrointestinal tract: higher abundance and sensitivity of TRPV1 channels in rectum and distal colon than in transverse and proximal colon.2008

    • Author(s)
      Kenjiro Matsumoto, Kimihito Tashima, Syunji Horie
    • Organizer
      Digestive Disease Week and the 109th Annual Meeting of the American Gastroenterological Association Institute
    • Place of Presentation
      Washington, D.C, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] マウス摘出下部消化管におけるバニロイド受容体TRPV1の局在とカプサイシン誘起平滑筋収縮作用機序の解明2008

    • Author(s)
      松本健次郎、田嶋公人、堀江俊治
    • Organizer
      生体機能と創薬シンポジウム2008
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] マウス摘出下部消化管におけるバニロイド受容体TRPV1の局在とカプサイシン誘起平滑筋収縮作用機序の解明2008

    • Author(s)
      松本健次郎
    • Organizer
      生体機能と創薬シンポジウム2008
    • Place of Presentation
      品川
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット培養胃粘膜細胞におけるワサビ辛味成分アリルイソチオシアネートのタイトジヤンクションバリアに対する作用2008

    • Author(s)
      佐藤翔吾
    • Organizer
      第36回日本潰瘍学会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] 気剤生薬成分の消化管機能調節作用2008

    • Author(s)
      矢野眞吾
    • Organizer
      第25回和漢医薬学会学術大会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス下部消化管におけるバニロイド受容体TRPV1の免疫組織学的検討2008

    • Author(s)
      松本健次郎
    • Organizer
      第118回日本薬理学会関東部会
    • Place of Presentation
      品川
    • Related Report
      2008 Annual Research Report
  • [Presentation] 喘息病態モルモットの気管におけるバニロイド受容体について2007

    • Author(s)
      渡邉 直人
    • Organizer
      第9回日本咳嗽研究会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 消化器疾患とバニロイドレセプター 辛味は消化器でも味わう:バニロイドレセプターTRPV1による消化管機能調節2007

    • Author(s)
      堀江俊治
    • Organizer
      ランチョンセミナー。Japan Digestive Disease Week 2007
    • Place of Presentation
      神戸
    • Year and Date
      2007-10-20
    • Related Report
      2008 Final Research Report
  • [Presentation] 消化器疾患とバニロイドレセプター 辛味は消化器でも味わう:バニロイドレセプターTRPV1による消化管機能調節2007

    • Author(s)
      堀江 俊治
    • Organizer
      Japan Digestive Disease Week 2007
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2007-10-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cold receptor TRPA1 mediate the smooth muscle contraction in isolated mouse lower intestinal tract.2007

    • Author(s)
      Kimihito Tashima, Penuelas Angelica, Shizuko Tsuchiya, Kenjiro Matsumoto, Tomonori Nakamura, Shingo Yano, Syunji Horie
    • Organizer
      Digestive Disease Week
    • Place of Presentation
      Washington, DC
    • Related Report
      2008 Final Research Report
  • [Presentation] マウス摘出下部消化管標本におけるワサビ成分アリルイソチオシアネートの平滑筋収縮作用:低温感受性チャネルTRPA1の関与2007

    • Author(s)
      堀江俊治、Angelica Penuelas、土屋静子、中村智徳、矢野眞吾、松本健次郎、田嶋公人
    • Organizer
      第24回和漢医薬学会大会
    • Place of Presentation
      富山
    • Related Report
      2008 Final Research Report
  • [Presentation] ラット胃粘膜初代培養細胞のタイトジャンクションバリアに対する温度感受性TRPV1, TRPM8, およびTRPA1チャネル作動薬の作用2007

    • Author(s)
      佐藤翔吾、田嶋公人、松本健次郎、土屋静子、矢野眞吾、村山俊彦、堀江俊治
    • Organizer
      第35回日本潰瘍学会
    • Place of Presentation
      鳥取
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of capsaicin via TRPV1 in isolated mouse lower gastrointestinal tract and the influence of neonatal stress.2007

    • Author(s)
      Syunji Horie, Kenjiro Matsumoto, Kimihito Tashima
    • Organizer
      International Society for Autonomic Neuroscience (ISAN) 2007
    • Place of Presentation
      Kyoto
    • Related Report
      2008 Final Research Report
  • [Presentation] マウス摘出下部消化管標本におけるワサビ成分アリルイソチオシアネートの平滑筋収縮作用:低温感受性チャネルTRPA1の関与2007

    • Author(s)
      堀江 俊治
    • Organizer
      第24回和漢医薬学会大会
    • Place of Presentation
      富山国際会議場
    • Related Report
      2007 Annual Research Report
  • [Presentation] NOを介する附子アルカロイド・メサコニチンの内皮依存性血管弛緩作用2007

    • Author(s)
      堀江 俊治
    • Organizer
      生体機能と創薬シンポジウム2007
    • Place of Presentation
      金沢大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラット胃粘膜初代培養細胞のタイトジャンクションバリアに対する温度感受性TRpV],TRPM8,およびTRPA】チャネル作動薬の作用2007

    • Author(s)
      佐藤 翔吾
    • Organizer
      第35回日本潰瘍学会
    • Place of Presentation
      烏取県民ふれあい会館
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of capsaicin via TRPVJ in isolated mouse lower gastrointestinna tract and the influcnce of neonatal stress2007

    • Author(s)
      Syunji Horie
    • Organizer
      Internatjonal Society for Autonomic Neuroscience(ISAN) 2007
    • Place of Presentation
      京都テルサ
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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