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Quantitative prediction of drug-drug interactions in the intestinal first pass metabolism

Research Project

Project/Area Number 19590157
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionKitasato University

Principal Investigator

ITOH Tomoo  Kitasato University, 薬学部, 教授 (30223168)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords薬学 / 小腸 / 初回通過効果 / 薬物相互作用 / CYP3A4
Research Abstract

当研究室で提唱してきたITAM(intestinal transit, absorption and metabolism)modelを用いて、ヒトに経口投与された薬物の小腸初回通過効果における薬物相互作用を、in vitro実験から定量的に予測する道筋が示された。今後、本手法が改良されることにより、重篤な薬物相互作用を未然に回避できることが期待される。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (23 results)

All 2010 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (15 results) Book (4 results)

  • [Journal Article] Stereoselective transport of amethopterin enantiomers by the proton-coupled folate transporter2010

    • Author(s)
      Narawa T, Itoh T
    • Journal Title

      Drug Metab. Pharmacokin (in press)

    • NAID

      10027582937

    • Related Report
      2008 Final Research Report
  • [Journal Article] Quantitative Prediction of Oral Absorption of PEPT1 Substrates Based on in vitro Uptake into Caco-2 Cells2008

    • Author(s)
      Shimizu R, Sukegawa T, Tsuda Y, Itoh T
    • Journal Title

      Int J Pharmaceut 354

      Pages: 104-110

    • Related Report
      2008 Final Research Report
  • [Journal Article] Quantitative Prediction of Oral Absorption of PEPT1 Substrates Based on in vitro Uptake into Caco-2 Cells.2008

    • Author(s)
      R. Shimizu, T. Sukegawa, Y. Tsuda, T. Itoh
    • Journal Title

      Int. J. Pharmaceut. 354

      Pages: 104-110

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative Prediction of Oral Absorption of PEPT1 Substrates Based on in vitro Uptake into Caco-2 Cells2008

    • Author(s)
      R.Shimizu, T.Sukegawa, Y.Tsuda, T.Iitoh
    • Journal Title

      Int.J.Pharmaceut. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 薬物輸送担体の立体選択性2008

    • Author(s)
      伊藤智去
    • Organizer
      Symposium on Molecular Chirality
    • Place of Presentation
      岡山
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒトPGFT/HGP1の立体選択性2008

    • Author(s)
      奈良輪知也, 伊藤智夫
    • Organizer
      日本薬剤学会第23年会
    • Place of Presentation
      札幌
    • Year and Date
      2008-05-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Reduced Folate Carrier (RFC) の基質認識における立体選択性の解明2008

    • Author(s)
      柳沢秀明, 奈良輪知也, 伊藤智夫
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Proton-coupled folate transporter /Heme carrier protein 1の立体選択的輸送2008

    • Author(s)
      奈良輪知也, 田中裕子, 柳沢秀明, 伊藤智夫
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] ラットにおけるCYP3A基質の小腸アベイラビリティの検討2008

    • Author(s)
      野口直子, 津田泰之, 伊藤智夫
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Midazolam によるヒトCYP3Aの不可逆的阻害2008

    • Author(s)
      岩瀬由未子, 津田泰之, 伊藤智夫
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] シンポジウム : 薬学教育改革最前線「共用試験トライアルの状況」2008

    • Author(s)
      宮崎智, 伊藤智夫, 伊藤喬, 山元弘, 入江徹美
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] CONSTRUCTION OF A THREE-DIMENTIONAL MODEL AND PREDICTION OF THE SUBSTRATE-BINDING SITES OF OATP2B12008

    • Author(s)
      Takano S., Uchida M., Kanou K., Takeda-Shitaka M., Umeyama H., Itoh T.
    • Organizer
      第23回日本薬物動態学会年会
    • Related Report
      2008 Final Research Report
  • [Presentation] Prediction of intestinal availability of alprazolam in rats2007

    • Author(s)
      Noguchi N, Tsuda Y, Itoh T
    • Organizer
      8^<th> International ISSX Meeting (Senadai)
    • Year and Date
      2007-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Stereo selectivity of the proton-coupled folate transporter/heme carrier protein 1 (PCFT/HCP1)2007

    • Author(s)
      Narawa T, Yanagisawa H, Tsuda Y, Itoh T
    • Organizer
      8^<th> International ISSX Meeting (Senadai)
    • Year and Date
      2007-10-11
    • Related Report
      2008 Final Research Report
  • [Presentation] Stereoselective transport of amethopterin enantiomers by reduced folate carrier 12007

    • Author(s)
      Yanagisawa H, Narawa T, Itoh T
    • Organizer
      8^<th> International ISSX Meeting (Senadai)
    • Year and Date
      2007-10-11
    • Related Report
      2008 Final Research Report
  • [Presentation] Prediction of human intestinal availability of CYP3A4 substrates based on in vitro studies 4^<th> World Conference on Drug Absorption2007

    • Author(s)
      Iwase Y, Ishiji M, Tsuda Y, Itoh T
    • Organizer
      Transport and Delivery
    • Place of Presentation
      Kanazawa
    • Year and Date
      2007-06-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Stereoselective transport system of amethopterin enantiomers 4^<th> World Conference on Drug Absorption2007

    • Author(s)
      Narawa T, Yanagisawa H, suda Y, Itoh T
    • Organizer
      Transport and Delivery
    • Place of Presentation
      Kanazawa
    • Year and Date
      2007-06-20
    • Related Report
      2008 Final Research Report
  • [Presentation] ホモロジーモデリングによるOATP2B1の基質結合部位の推定2007

    • Author(s)
      内田めぐみ, 高野修平, 加納和彦, 竹田一志, 鷹真由子, 梅山秀明, 伊藤智夫
    • Organizer
      第2回トランスポーター研究会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] CATモデルに基づいた小腸初回通過代謝における薬物間相互作用の予測2007

    • Author(s)
      岩瀬 由未子、石地 正隆、伊藤 智夫
    • Organizer
      日本薬剤学会第20年会
    • Place of Presentation
      さいたま市(埼玉県)
    • Related Report
      2007 Annual Research Report
  • [Book] 伊賀勝美・伊藤智夫・堀江利治(編) 対話と演習で学ぶ 薬物速度論2008

    • Author(s)
      伊藤智夫(分担執筆・編集)
    • Publisher
      東京 廣川書店
    • Related Report
      2008 Final Research Report
  • [Book] 薬学実務実習開始前の共用試験 (平成19年度)2008

    • Author(s)
      伊藤智夫(分担執筆)
    • Publisher
      東京 NPO法人 薬学共用試験センター
    • Related Report
      2008 Final Research Report
  • [Book] 対話と演習で学ぶ 薬物速度論2008

    • Author(s)
      伊賀勝美, 伊藤智夫, 堀江利治(編)
    • Total Pages
      228
    • Publisher
      廣川書店
    • Related Report
      2008 Annual Research Report
  • [Book] 薬学実務実習開始前の共用試験 (平成18年度)2007

    • Author(s)
      伊藤智夫(分担執筆)
    • Publisher
      東京 NPO法人 薬学共用試験センター
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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