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The novel mode of action of axon guidance molecules, semaphorins in tissue remodeling of mouse female genital organ

Research Project

Project/Area Number 19590178
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionMeijo University (2008)
Wakayama Medical University (2007)

Principal Investigator

YUKAWA Kazunori  Meijo University, 薬学部, 教授 (20301434)

Co-Investigator(Kenkyū-buntansha) TAKEUCHI Noriko  名城大学, 薬学部, 助手 (80076728)
田中 哲二  和歌山県立医科大学, 医学部, 准教授 (80275255)
上山 敬司  和歌山県立医科大学, 医学部, 准教授 (50264875)
Co-Investigator(Renkei-kenkyūsha) TANAKA Tetsuji  和歌山県立医科大学, 医学部, 准教授 (80275255)
UEYAMA Takashi  和歌山県立医科大学, 医学部, 准教授 (50264875)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords発生学 / 形態形成学 / 組織リモデリング / セマフォリン / アポトーシス
Research Abstract

マウスは5週齢の性ホルモン分泌急増に伴い皮膚近傍の膣末端部上皮細胞の細胞死(アポトーシス)が誘導され、膣腔が皮膚に貫通(膣開口)する組織リモデリング現象を経て生殖器発達が完成する。私共の解析から、セマフォリン分子群に属するセマフォリン4D(Sema4D)の遺伝子欠損マウスでは、膣開口が起こらず膣閉鎖を発症し、5週齢マウス膣末端部におけるアポトーシス細胞の顕著な減少が明らかになった。2007~2008年度科学研究費研究計画実施の結果、Sema4Dのマウス膣上皮細胞に対するアポトーシス誘導作用が証明され、Sema4Dによるアポトーシス誘導にはPlexin-B1受容体が関与することが判った。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (19 results)

All 2009 2008 2007

All Journal Article (15 results) (of which Peer Reviewed: 13 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Sema4D/CD100 deficiency leads to superior performance in mouse motor behavior2009

    • Author(s)
      Yukawa K, Tanaka T, Takeuchi N, Iso H, Li L, Kohsaka A, Waki H, Miyajima M, Maeda M, Kikutani H, Kumanogoh A
    • Journal Title

      Can J Neurol Sci 36

      Pages: 349-355

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Irinotecan-induced ovarian follicular apoptosis is attenuated by deleting the kinase domain of death-associated protein kinase2009

    • Author(s)
      Li L, Tanaka T, Yukawa K, Akira S, Umesaki N
    • Journal Title

      Int J Oncol 34

      Pages: 905-914

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Irinotecan-induced ovarian follicular apoptosis is attenuated by deleting the kinase domain of death-associated protein kinase.2009

    • Author(s)
      Li L, Tanaka T, Yukawa K, Akira S, Umesaki N
    • Journal Title

      International Journal of Oncolopgy 34

      Pages: 905-914

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microinjection of urocortin into the rat nucleus tractus solitarii decreases arterial blood pressure2008

    • Author(s)
      Yamazaki T, Waki H, Kohsaka A, Nakamura T, Cui H, Yukawa K, Maeda M
    • Journal Title

      Auton Neurosci 142(1-2)

      Pages: 51-4

    • NAID

      130005449201

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin 2 microinjection into the nucleus tractus solitarius elevates arterial pressure and heart rate in rats2008

    • Author(s)
      Cui H, Kohsaka A, Waki H, Gouraud S, Nakamura T, Yukawa K, Hatada A, Bhuiyan ME, Maeda M
    • Journal Title

      Auton Neurosci 142(1-2)

      Pages: 45-50

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Experimental characterization of recurrent ovarian immature teratoma cells after optimal surgery2008

    • Author(s)
      Tanaka T, Toujima S, Utsunomiya T, Yukawa K, Umesaki N
    • Journal Title

      Oncol Rep 20(1)

      Pages: 13-23

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Controlling death-associated protein kinase activity to protect kidney cell suicide in renal ischemia-reperfusion injury Review paper2008

    • Author(s)
      Yukawa K, Tanaka T, Takeuchi N, Waki H, Kohsaka A, Maeda M
    • Journal Title

      Jpn J Clin Physiol 38(6)

      Pages: 243-250

    • Related Report
      2008 Final Research Report
  • [Journal Article] The sympathoexcitatory pathway from the CVL to the RVL for controlling brain vessels. Review article2008

    • Author(s)
      Maeda M, Waki H, Kohsaka A, Yukawa K, Nakamura T
    • Journal Title

      zu Chi Medical J 20(4)

      Pages: 243-7

    • Related Report
      2008 Final Research Report
  • [Journal Article] Experimental characterization of recurrent ovarian immature teratoma cellsafter optimal surgery.2008

    • Author(s)
      Tanaka T, Toujima S, Utsunomiya T, Yukawa K, Umesaki N
    • Journal Title

      Oncology Report 20

      Pages: 13-23

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin 2 microinjection into the nucleus tractus solitarius elevatesarterial pressure and heart rate in rats.2008

    • Author(s)
      Cui H, Yukawa K (9名中6番目)
    • Journal Title

      Autonomic Neuroscience 142

      Pages: 45-50

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microinjection of urocortin into the rat nucleus tractus solitarii decreasesarterial blood pressure.2008

    • Author(s)
      Yamazaki T, Yukawa K (7名中6番目)
    • Journal Title

      Autonomic Neuroscience 142

      Pages: 51-54

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiation reduces carboplatin sensitivity and enhances nedaplatin sensitivity in cervical squamous cell carcinoma in vitro2007

    • Author(s)
      Tanaka T, Yukawa K, Umesaki N
    • Journal Title

      uropean Journal of Gynaecological Oncology XXVIII n.5

      Pages: 352-355

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiation reduces bleomycin sensitivity in cervical squamous cancer cells in vitro2007

    • Author(s)
      Tanaka T, Yukawa K, Umesaki N
    • Journal Title

      European Journal of Gynaecological Oncology XXVIII n.4

      Pages: 273-277

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiation reduces bleomycin sensitivity in cervical squamous cancer cells in vitro2007

    • Author(s)
      Tanaka T, Yukawa K, Umesaki N
    • Journal Title

      European Journal of Gynaecological Oncology 28(4)

      Pages: 273-277

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiation reduces carboplatin sensitivity and enhances nedaplatin sensitivity in cervical squamous cell carcinoma in vitro2007

    • Author(s)
      Tanaka T, Yukawa K, Umesaki N
    • Journal Title

      European Journal of Gynaecological Oncology 28(5)

      Pages: 352-355

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 遺伝性白内障ラット(UPL)の白内障発症に伴うクリスタリン変化2008

    • Author(s)
      竹内典子、石神志浦、今村知紗、林理紀、本多祐美、長井紀章、伊藤吉將、亀井鑠、湯川和典
    • Organizer
      第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Novel mode of action for axon guidance molecules, semaphorins in tissue remodeling of mouse genital organ2008

    • Author(s)
      Li L, Yukawa K, Bai T, Tanaka T, Waki H, Kohsaka A, Ueyama T, Kumanogoh A, Kikutani H, Maeda M
    • Organizer
      第85回日本生理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-25
    • Related Report
      2008 Final Research Report
  • [Presentation] Novel mode of action for axon guidance molecules, semaphorins in tissue remodeling of mouse famale genital organ2008

    • Author(s)
      Li Li, Yukawa K, Bai T, Tanaka T, Waki H, Kohsaka A, Ueyama T, Kumanogoh A, Kikutani H, Maeda M
    • Organizer
      第85回日本生理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-25
    • Related Report
      2007 Annual Research Report
  • [Book] 『第26章視床と大脳皮質』『Essential Neuroscience』前田正信2008

    • Author(s)
      湯川和典、向阪彰、前田正信(訳)
    • Publisher
      監訳(丸善発行)
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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