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Investigation of ATP-induced chemotaxis in preadipocytes

Research Project

Project/Area Number 19590207
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionShiga University of Medical Science

Principal Investigator

OMATSU-KANBE Mariko  Shiga University of Medical Science, 医学部, 准教授 (80161397)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords脂肪細胞 / 分化 / 細胞遊走 / 走化性 / ケモタキシス / ATP / P2受容体 / 増殖 / 前駆脂肪細胞 / 細胞接着 / 細胞分化
Research Abstract

マウスの前駆脂肪細胞である3T3-L1細胞を用い, その遊走性と生理的意義を検討した. 未分化脂肪細胞はATPに対して正の化学走性を示したが, 成熟脂肪細胞に遊走性を観察することはできなかった. 次に, マウスの腸管膜を細胞外基質として用いたところ, 細胞は約1時間で腸管膜表面に接着して移動を開始した.これらの結果から, 未分化脂肪細胞は生体内においても遊走性を持ち,オリジナルの脂肪組織塊から派生した細胞が離れた場所に移動して接着し, 増殖する可能性があると考えられた.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (24 results)

All 2009 2008 2007

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (12 results)

  • [Journal Article] A novel type of self-beatingcardiomyocytes in adult mouseventricles2009

    • Author(s)
      Omatsu-Kanbe, M. and Matsuura, H.
    • Journal Title

      Biochem. Biophy.s Res. Commun 381

      Pages: 361-366

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Swelling-Activated Cl-Current in Isolated Rabbit Articular Chondrocytes : Inhibition by Arachidonic Acid2009

    • Author(s)
      Isoya, E., Toyoda, F., Imai, S., Okumura,N., Kumagai, K., Omatsu-Kanbe, M.,Kubo, M., Matsuura, H., Matsusue, Y.
    • Journal Title

      J Pharmacol Sci. 109

      Pages: 293-304

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type1 receptor mediates partiallyhyposmotic-induce increase of I_<Ks>current in guinea pig atrium2009

    • Author(s)
      Zankov, D. P., Toyoda, F.,Omatsu-Kanbe, M., Matsuura, H., Horie, M.
    • Journal Title

      (In press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel type of self-beating cardiomyocytes in adult mouse ventricles.2009

    • Author(s)
      Omatsu, Kanbe, M., Matsuura, H
    • Journal Title

      Biochem. Biophy. s Res. Commun. 381

      Pages: 361-366

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Swelling-Activated Cl Current in Isolated Rabbit Articular Chondrocytes : Inhibition by Arachidonic Acid.2009

    • Author(s)
      Isoya, E., Toyoda, F., Imai, S., Okumura, N., Kumagai, K., Omatsu-Kanbe, M., Kubo, M., Matsuura, H., Matsusue, Y.
    • Journal Title

      J Pharmacol Sci. 109

      Pages: 293-304

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type l receptor mediates partially hyposmotic-induce increase of IKs current in guinea pig atrium.2009

    • Author(s)
      Zankov, D. P., Toyoda, F., Omatsu-Kanbe, M., Matsuura, H., Horie, M.
    • Journal Title

      Pflugers Arch. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心房筋伸展によるAT_1受容体を介した緩徐活性型遅延整流性K^+電流(I_<Ks>)の増大 ; 心房細動のARBによるアップストリーム治療のメカニズム2008

    • Author(s)
      松浦博, Dimitar P. Zankov, 尾松万里子, 堀江稔
    • Journal Title

      分子血管病 9

      Pages: 456-461

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 心房筋伸展によるAT_1受容体を介した緩徐活性型遅延整流性K^+電流(I_<Ks>)の増大 ; 心房細動のARBによるアツプストリーム治療のメカニズム2008

    • Author(s)
      松浦博, Dimitar P. Zankov, 尾松万里子, 堀江稔
    • Journal Title

      分子心血管病 9

      Pages: 456-461

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory action of proteinkinase Cbeta inhibitor ontetrodotoxin-resistant Na^+ currentin small dorsal root ganglionneurons in diabetic rats2007

    • Author(s)
      Hayase, F., Matsuura H., Sanada M.,Kitada-Hamada K., Omatsu-Kanbe M.,Maeda, K., Kashiwagi, A. and Yasuda, H.
    • Journal Title

      Neurosci Lett. 417

      Pages: 90-94

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] イオンチャネル異常による致死性不整脈2007

    • Author(s)
      松浦博, Dimitar P. Zankov, 尾松万里子, 礒野高敬, 豊田太, 丁維光, 堀江稔
    • Journal Title

      心房筋細胞におけるAT_1受容体を介した緩徐活性型遅延整流性K^+電流(I_<Ks>)の増大と活動電位の短縮-心房筋細胞治療におけるAT_<1>受容体遮断薬の有効性との関連-日本心電学会誌「心電図」 27

      Pages: 145-153

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory action of protein kinase Cbeta inhibitor on tetrodotoxin-resistant Na^+ current in small dorsal root ganglion neurons in diabetic rats2007

    • Author(s)
      F. Hayase
    • Journal Title

      Neurosci Lett 417

      Pages: 90-94

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] イオンチャネル異常による致死性不整脈心房筋細胞におけるAT_1受容体を介した緩徐活性型遅延整流性K^+電流(Iks)の増大と活動電位の短縮-心房筋細胞治療におけるAT1受容体遮断薬の有効性との関連-2007

    • Author(s)
      松浦 博
    • Journal Title

      日本心電学会誌「心電図」 27

      Pages: 145-153

    • Related Report
      2007 Annual Research Report
  • [Presentation] Cell migration of preadipocytes on the isolated mouse mesentery.2008

    • Author(s)
      Omatsu, Kanbe, M., Pujii, Y, Matsuura, H.
    • Organizer
      J. Physiol. Sci. 58, S202(第85回日本生理学会大会)
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cell migration ofpreadipocytes on the isolated mousemesentery2008

    • Author(s)
      Omatsu-Kanbe, M., Fujii, Y & Matsuura, H.
    • Organizer
      Journal of Physiological Sciences 58(第85回日本生理学会大会)
    • Place of Presentation
      東京(S202)
    • Related Report
      2008 Final Research Report
  • [Presentation] Angiotensin II Type 1 Receptor Partially Mediates Hypoosmotic-Induced Increase of Guinea Pig Atrial I^<Ks> Current2008

    • Author(s)
      Zankov, D.P., Toyoda, F., Omatsu-Kanbe,M., Matsuura, H. & Horie, M.
    • Organizer
      52^<nd> Annual Meeting ofBiophysical Society
    • Place of Presentation
      Long Beach, Florida,USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Angiotensin II Type 1 Receptor Partially Mediates Hypoosmotic-Induced Increase of Guinea Pig Atrial Iks Current2008

    • Author(s)
      Zankov, D. P.
    • Organizer
      52nd Annual Meeting of Biophysical Society
    • Place of Presentation
      Long Beach, Florida, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cell migration of preadipocytes on the isolated mouse mesentery2008

    • Author(s)
      Omatsu-Kanbe, M.
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] Extracellular ATP-induced cell migration of pradipocytes : Chemotaxis and chemokinesis2007

    • Author(s)
      Omatsu-Kanbe, M., Fujii, Y, & Matsuura, H.
    • Organizer
      Journal of Physiological Sciences 57(第84回日本生理学会大会)
    • Place of Presentation
      大阪(S86)
    • Related Report
      2008 Final Research Report
  • [Presentation] Role of phosphoproteins modified by the stimulation of P2Y receptor in adipocyte differentiation2007

    • Author(s)
      Fujii, Y., Omatsu-Kanbe, M., Isono, T. & Matsuura, H.
    • Organizer
      Journal of Physiological Sciences 57(第84回日本生理学会大会)
    • Place of Presentation
      大阪(S125)
    • Related Report
      2008 Final Research Report
  • [Presentation] 心房筋細胞におけるAT_1受容体を介した緩徐活性型遅延整流性K^+電流(I_<Ks>)の増大と活動電位の短縮-心房細動治療におけるAT_<1>重油対遮断薬の有効性との関連-2007

    • Author(s)
      松浦博, Dimitar P. Zamkov, 尾松万里子, 礒野高敬, 豊田太, 丁維光, 堀江稔
    • Organizer
      Japanese Journal of Electrocardiology(第23回日本心電学会シンポジウム)
    • Place of Presentation
      東京(7)(145-153)
    • Related Report
      2008 Final Research Report
  • [Presentation] Angiotensin II Type 1 Receptor Partially Mediates Stretch-Induced Potentiation of the Slow Component of Delayed Rectifier Potassium Current in Guinea Pig Atrium2007

    • Author(s)
      Zankov, D.P., Toyoda, F., Omatsu-Kanbe,M., Matsuura, H. & Horie, M.
    • Organizer
      Scientific Session 2007 of American Heart Association
    • Place of Presentation
      Orland,Florida, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Upregulation of HERG potassium channel function by phosphatidylinositol-4-phosphatase 5-kinase2007

    • Author(s)
      Kubo, T., Ding, W.-G., Toyoda, F., Fujii, Y., Omatsu-Kanbe, M., Miura, Y., Mino, T. & Matsuura, H.
    • Organizer
      European Heart Journal
    • Place of Presentation
      European Society of Cardiology Congress 2007, Vienna,Austria(28)
    • Related Report
      2008 Final Research Report
  • [Presentation] Angiotensin II Type 1 Receptor Partially Mediates Stretch-Induced Potentiation of the Slow Component of Delayed Rectifier Potassium Current in Guinea Pig Atrium2007

    • Author(s)
      Zankov, D. P
    • Organizer
      Scientific Session 2007 of American Heart Associati
    • Place of Presentation
      Orland, Florida, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Upregulation of HERG potassium channel function by phosphati dylinositol-4-phosphatase 5-kinase2007

    • Author(s)
      Kubo, T.
    • Organizer
      European Heart Journal 28, 223-224(European Society of Cardiology Congress 2007)
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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