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Involvement of free fatty acids and 20-hydroxyeicosatetraenoic acid(20-HETE)in ischemic stroke

Research Project

Project/Area Number 19590244
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

TAKEUCHI Kazuhiko  Hamamatsu University School of Medicine, 医学部, 准教授 (00419425)

Co-Investigator(Kenkyū-buntansha) WATANABE Hiroshi  浜松医科大学, 医学部・臨床薬理学, 教授 (50262803)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords循環 / 虚血性脳卒中 / 血管内皮 / 内皮依存性血管拡張因子 / NO / プロスタグランジンI2 / カルシウム / 遊離脂肪酸
Research Abstract

主なヒト血中遊離脂肪酸中、ω6多価不飽和脂肪酸であるアラキドン酸とリノール酸は、血管内皮細胞内カルシウム応答の抑制を介して内皮依存性血管拡張因子(プロスタグランジンI_2及びNO)の産生を低下させた。しかし、他の遊離脂肪酸には、このような抑制効果はみられなかった。アラキドン酸による血管内皮機能抑制作用がアラキドン酸-20-HETE(脳血管攣縮への関与が報告されている)経路を介したものであるかを検討したが、有意な結果は得られなかった。これらの結果は、脳心血管イベントをはじめとする血管機能障害と遊離脂肪酸との関連を考える際に、遊離脂肪酸のプロファイルが重要であることが明らかとなった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2009 2008 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Misinterpretation of the effect of amlodipine on cytosolic calcium concentration with fura-2 fluorospectrometry2008

    • Author(s)
      Asai M, Takeuchi K, Saotome M, Urushida T, Katoh H, Satoh H, Hayashi H, Watanabe H.
    • Journal Title

      Naunyn-Schmiede berg's Archives of Pharmacology 377(4-6)

      Pages: 423-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Misinterpretation of the effect of amlodipine on cytosolic calcium concentration with fura-2 fluorospectrometry2008

    • Author(s)
      Asai M, Takeuchi K, Watanabe H
    • Journal Title

      Naunyn-Schmiedeberg's Archives of Pharmacology 377(4-6)

      Pages: 423-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular acidosis suppresses endothelial function by inhibiting store-operated Ca^<2+> entry via nonselective cation channels

    • Author(s)
      Asai M, Takeuchi K, Saotome M, Urushida T, Katoh H, Satoh H, Hayashi H, Watanabe H.
    • Journal Title

      Cardiovascular Research (in press)

    • Related Report
      2008 Final Research Report
  • [Presentation] 酸性環境下における血管内皮機能2009

    • Author(s)
      竹内和彦、浅井正嘉、渡邉裕司
    • Organizer
      第9回日本NO学会学術集会
    • Place of Presentation
      静岡
    • Year and Date
      2009-05-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Omega-6 polyunsaturated fatty acids, arachidonic and linoleic acids, but not other free fatty acids, suppress endothelial Ca^<2+> signaling and functions2009

    • Author(s)
      Takeuchi K, Watanabe H.
    • Organizer
      第73回日本循環器学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Omega-6 Polyunsaturated Fatty Acids, Arachidonic and Linoleic acids, but not other Free Fatty Acids, Suppress Endothelial Ca2+ Signaling and Functions2009

    • Author(s)
      Takeuchi K, Asai M, Watanabe H
    • Organizer
      第73回日本循環器学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-03-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Free fatty acids(FFAs), arachidonic and linoleic acids but not other FFAs, suppress endothelial function by inhibiting endothelial Ca^<2+> responses2008

    • Author(s)
      Takeuchi K, Watanabe H.
    • Organizer
      第73回日本循環器学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Free Fatty Acids (FFAs), Arachidonic and Linoleic Acids but not other FFAs,Suppress Endothelial Function by Inhibiting Endothelial Ca2+ Responses2008

    • Author(s)
      Takeuchi K, Iida K, Watanabe H
    • Organizer
      第72回日本循環器学会学術総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www2.hama-med.ac.jp/w1b/cpharm/clinpharm.html

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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