Nicotine-induced remodeling of synapse in hippocampal neuron.
Project/Area Number |
19590247
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General pharmacology
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Research Institution | Osaka University |
Principal Investigator |
TANAKA Hidekazu Osaka University, 大学院・医学系研究科, 准教授 (70273638)
|
Project Period (FY) |
2007 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 中枢神経 / ニコチン / シナプス / 可塑性 / スパイン / 認知症 / 薬物依存 / 海馬 |
Research Abstract |
Nicotine was discovered to induce synaptic remodeling. The remodeling of dendritic spine, the postsynaptic structure, was visualized with green fluorescent protein (GFP) in cultured hippocampal neurons. One-two hours after the application of nicotine, a several micrometer-long filopodia protruded from the head of mushroom-shaped spine. This unique remodeling of spine head suggests a kind of the destabilization of synaptic connection, which may result in the rewiring of neural circuit. This phenomenon might be one of the mechanisms underlying the nicotine addiction.
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Report
(6 results)
Research Products
(37 results)
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[Journal Article] Retrospective review of Japanese sudden unexpected death in infancy: the importance of metabolic autopsy and expanded newborn screening.2011
Author(s)
Yamamoto T, Tanaka H, Kobayashi H, Okamura K, Tanaka T, Emoto Y, Sugimoto K, Nakatome M, Sakai N, Kuroki H, Yamaguchi S, Matoba R.
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Journal Title
Mol Genet Metab. 102
Pages: 399-406
Related Report
Peer Reviewed
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[Journal Article] A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules.2010
Author(s)
Shiraya K, Hirata T, Hatano R, Nagamori S, Wiriyasermkul P, Jutabha P, Matsubara M, Muto S, Tanaka H, Asano S, Anzai N, Endou H, Yamada A, Sakurai H, Kanai Y.
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Journal Title
J Biol Chem. 285
Pages: 22141-22151
Related Report
Peer Reviewed
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[Journal Article] A novel role of the C-terminus of b 0,+ AT in the ER-Golgi trafficking of the rBAT-b 0,+ AT heterodimeric amino acid transporter.2009
Author(s)
Sakamoto S, Chairoungdua A, Nagamori S, Wiriyasermkul P, Promchan K, Tanaka H, Kimura T, Ueda T, Fujimura M, Shigeta Y, Naya Y, Akakura K, Ito H, Endou H, Ichikawa T, Kanai Y.
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Journal Title
Biochem J. 417
Pages: 441-448
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Peer Reviewed
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[Journal Article] Synaptic Activity-induced Protocadherin Arcadlin Regulates Dendritic Spine Number by Triggering N-Cadherin Endocytosis via TAO2β and p38 MAP Kinases.2007
Author(s)
Yasuda S, Tanaka H, Sugiura H, Okamura K, Sakaguchi T, Tran U, Takemiya T, Mizoguchi A, Yagita Y, Sakurai T, De Robertis EM, Yamagata K.
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Journal Title
Neuron. 56
Pages: 456-471
Related Report
Peer Reviewed
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[Journal Article] Granulocyte colony-stimulating factor has a negative effect on stroke outcome in a murine model.2007
Author(s)
Taguchi A, Wen Z, Myojin K, Yoshihara T, Nakagomi T, Nakayama D, Tanaka H, Soma T, Stern DM, Naritomi H, Matsuyama T.
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Journal Title
Eur J Neurosci. 26
Pages: 126-33
Related Report
Peer Reviewed
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[Journal Article] Synaptic Activity-induced Protocadherin Arcadlin Regulates Dendritic Spine Number by Triggering N-Cadherin Endocytosis via TAO2β and p38 MAP Kinases2007
Author(s)
Yasuda S, Tanaka H, Sugiura H, Okamura K, Sakaguchi T, Tran U, Takemiya T, Mizoguchi A, Yagita Y, Sakurai T, De Robertis EM, Yamagata K
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Peer Reviewed
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