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Does ATP / adenosine system protect sympathetic nerve of an ischemic heart in life-style related diseases model rat?

Research Project

Project/Area Number 19590263
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionMukogawa Women's University

Principal Investigator

SHINOZUKA Kazumasa  Mukogawa Women's University, 薬学部, 教授 (50117777)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords中枢 / 末梢神経 / 虚血再灌流 / ATP / アデノシン / メタボリックシンドローム / 虚血心臓 / 血管交感神経 / 保護作用 / 血管内皮細胞 / 虚血再潅流 / 生活習慣病 / 薬理学 / 脳・神経
Research Abstract

自然発症高血圧ラット(SHR)や生活習慣病モデル動物(SHR.Cg-Leprcp/NDmcrats)において、交感神経終末部のATP・アデノシン受容体が機能不全を起こしていることを見いだした。一方、低酸素時には心臓から大量のアデノシンが放出され、酸素再通気後もその放出は増加し続けることを見いだした。本結果より、生活習慣病の進展とともに交感神経伝達の抑制性調節機構が破綻し、これがこの病態におけるプレコンディショニングの破綻の一部に関与している可能性が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (22 results)

All 2009 2008 2007

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (6 results)

  • [Journal Article] Chronic production of peroxynitrite in the vascular wall impairs vasorelaxation function in SHR/NDmcr-cp rats, an animal model of metabolic syndrome.2009

    • Author(s)
      Kagota S, Tada Y, Nejime N, Nakamura K, Kunitomo M, Shinozuka K.
    • Journal Title

      J Pharmacol Sci. 109(4)

      Pages: 556-564

    • NAID

      10025735851

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ATP on the intracellular calcium level in the osteoblastic TBR31-2 cell line.Effects of ATP on the intracellular calcium level in the osteoblastic TBR31-2 cell line.2009

    • Author(s)
      Nishii N, Nejime N, Yamauchi C, Yanai N, Shinozuka K, Nakabayashi T.
    • Journal Title

      Biol Pharm Bull. 32(1)

      Pages: 18-23

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible participation of chloride ion channels in ATP release from cancer cells in suspension.2009

    • Author(s)
      Nejime N, Kagota S, Tada Y, Nakamura K, Hashimoto M, Kunitomo M, Shinozuka K.
    • Journal Title

      Clin Exp Pharmacol Physiol. 36(3)

      Pages: 278-282

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible Participation of chloride ion channels in ATP release from cancer cells in suspension.2009

    • Author(s)
      Nejime N, 等
    • Journal Title

      Clin Exp Pharmacol Physiol 377

      Pages: 278-282

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 代謝症候群モデルラット尾動脈交感神経伝達に対するニコランジルの影響2008

    • Author(s)
      橋本道男、鄭婀美、田邊洋子、禰占奈美江、多田有加里、籠田智美、篠塚和正
    • Journal Title

      Therapeutic Res. 29

      Pages: 7-11

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of P2 receptor on the intracellular calcium increase by cancer cells in human umbilical vein endothelial cells.2008

    • Author(s)
      Nejime N, Tanaka N, Yoshihara R, Kagota S, Yoshikawa N, Nakamura K, Kunitomo M, Hashimoto M, Shinozuka K
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol. 377(4-6)

      Pages: 429-436

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 代謝症候群モデルラツト尾動脈交感神経伝達に対するニコランジルの影響2008

    • Author(s)
      橋本道男, 等
    • Journal Title

      Therapeutic Research 29

      Pages: 7-11

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of P2 receptor on the intracellular calcium increase by cancer cells in human umbilical vein endothelial cells.2008

    • Author(s)
      Nejime N, 等
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol 377

      Pages: 429-436

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peroxynitrite is Involved in the dysfunction of vasorelaxation in SHR/NDmcr-cp rats, spontaneously hypertensive obese rats.2007

    • Author(s)
      Kagota S, Tada Y, Kubota Y, Nejime N, Yamaguchi Y, Nakamura K, Kunitomo M, Shinozuka K.
    • Journal Title

      J Cardiovasc Pharmacol. 50(6)

      Pages: 677-685

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired effect of salt loading on nitric oxide-mediated relaxation in aortas from stroke-prone spontaneously hypertensive rats.2007

    • Author(s)
      Kagota S, Kubota Y, Nejime N, Nakamura K, Kunitomo M, Shinozuka K.
    • Journal Title

      Clin Exp Pharmacol Physiol. 34(1-2)

      Pages: 48-54

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ATP modulates the release of noradrenaline through two different prejunctional receptors on the adrenergic nerves of rat prostate.2007

    • Author(s)
      Morikawa T, Tanaka N, Kubota Y, Mizuno H, Nakamura K, Kunitomo M, Shinozuka K.
    • Journal Title

      Clin Exp Pharmacol Physiol. 34(7)

      Pages: 601-605

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nicorandil may change the sympathetic nerve activity of SHR.Cg-Leprcp/NDmcr (SHR-cp) rats.2007

    • Author(s)
      Tei A, Tabuchi M. Nejime N, Kubota Y, Kagota S, Higashino H, Hashimoto M. Shinozuka K.
    • Journal Title

      Clin Exp Pharmacol Physiol. 34

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of hypertension on dysfunction of regulation of adrenergic neurotransmission in SHR.Cg-Lepr^<cp>/NDmcr (SHR-cp) rats.2007

    • Author(s)
      Nejime N, Kagota S, Yoshihara R, Tanaka N, Tei A, Kubota Y, Nakamura K, Kunitomo M. Shinozuka K.
    • Journal Title

      Clin Exp Pharmacol Physiol. 34

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ATP modulates the release of noradrenaline through two different prejunctional receptors on the adrenergic nerves of rat prostate2007

    • Author(s)
      Morikawa T
    • Journal Title

      Clinical and Experimental Pharmacology and Physiology 34

      Pages: 601-605

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nicorandil may change the sympathetic nerve activity of SHR.Cg-Leprcp/NDmcr(SHR-cp)rats2007

    • Author(s)
      Tei, A
    • Journal Title

      Clinical and Experimental Pharmacology and Physiology 34

      Pages: 31-32

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enfluence of hypertension on dysfunction of regulation of adrenergic neurotransmission in SHR.CG-Leprcp/NDmcr(SHR-cp)rats2007

    • Author(s)
      Nejime, N
    • Journal Title

      Clinical and Experimental Pharmacology and Physiology 34

      Pages: 33-34

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effect of cancer cells on the intracellular calcium ion levels in human umbilical vein endothelial cells via P2Y receptor2008

    • Author(s)
      Nejime N
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Changes in cardiac function in SHRSP.Z-Lepr^<fa>/IzmDmcr rats with metabolic syndrome2008

    • Author(s)
      Tada Y.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of nicorandil on the release of noradrenaline from rat caudal artery ラット尾動脈からのノルアドレナリン遊離に対するニコランジルの影響2008

    • Author(s)
      Tei A
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
    • Related Report
      2008 Final Research Report
  • [Presentation] 代謝症候群モデルラット尾動脈交感神経伝達に対するニコランジルの影響2007

    • Author(s)
      橋本道男
    • Organizer
      第20回ニコランジル研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Cancer cells effect on intracellular calcium ion levels of vascular endothelial cells via P2Y receptors.2007

    • Author(s)
      Nejime N
    • Organizer
      5^<th> International Symposium on Receptor Mechanisms, Signal Transductions and Drug Effects
    • Place of Presentation
      静岡
    • Related Report
      2008 Final Research Report
  • [Presentation] Changes in cardiac chronotropic and inotropic responses to beta and muscarinic receptor agonists in SHR/NDmcr-cp rats, an animal model of metabolic syndrome.2007

    • Author(s)
      Tada Y
    • Organizer
      5^<th> International Symposium on Receptor Mechanisms, Signal Transductions and Drug Effects
    • Place of Presentation
      静岡
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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