Analysis of the regulation of organelle-generated signals by the Novel endoplasmic protein calumin
| Project/Area Number |
19590267
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
YAMAZAKI Tetsuo Kyoto University, 薬学研究科, 准教授 (90330208)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | カルシウム / 小胞体 / 細胞内小器官 / シグナル |
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| Research Abstract |
研究者代表者はCa^(2+)結合能を有する小胞体タンパク質caluminをモデル分子として、小胞体発シグナルの分子論的理解を目指した.樹立したcalumin欠損マウスの75%は胎児期に死亡した. 背景に体液循環異常が示唆され、実際、同胎児の心血管系形成は未熟な段階で停止していた. また、Ca^(2+)依存性転写因子NFATの活性化が阻害されており、NFATc3/c4二重欠損マウスとの類似性(胎生致死、心血管異常)を鑑みると、caluminとNFATの機能共役が小胞体発シグナルの分子基盤の一端を成すと考えられた.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes2009
Author(s)
Masumiya H., Asaumi Y., Nishi M., Minamisawa S., Adachi-Akahane S., Yoshida M., Kangawa K., Ito K., Kagaya Y., Yanagisawa T., Yamazaki T. , Ma J. and Takeshima H
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins. Biochem. Biophys. Res2007
Author(s)
Ikeda A., Miyazaki T., Kakizawa S., Okuno Y., Tsuchiya S., Myomoto A., Saito S., Yamamoto T., Yamazaki T., Iino M., Tsujimoto G., Watanabe M. and Takeshima H
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Journal Title
Commun 363
Pages: 835-839
Related Report
Peer Reviewed
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