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Analysis of the regulation of organelle-generated signals by the Novel endoplasmic protein calumin

Research Project

Project/Area Number 19590267
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionKyoto University

Principal Investigator

YAMAZAKI Tetsuo  Kyoto University, 薬学研究科, 准教授 (90330208)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsカルシウム / 小胞体 / 細胞内小器官 / シグナル
Research Abstract

研究者代表者はCa^(2+)結合能を有する小胞体タンパク質caluminをモデル分子として、小胞体発シグナルの分子論的理解を目指した.樹立したcalumin欠損マウスの75%は胎児期に死亡した. 背景に体液循環異常が示唆され、実際、同胎児の心血管系形成は未熟な段階で停止していた. また、Ca^(2+)依存性転写因子NFATの活性化が阻害されており、NFATc3/c4二重欠損マウスとの類似性(胎生致死、心血管異常)を鑑みると、caluminとNFATの機能共役が小胞体発シグナルの分子基盤の一端を成すと考えられた.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report

Research Products

(17 results)

All 2009 2008 2007

All Journal Article Presentation Book

  • [Journal Article] New molecular components supporting ryanodine receptor-mediated Ca^<2+> release : roles of junctophilin and TRIC channel in embryonic cardiomyocyes2009

    • Author(s)
      Yamazaki D., Yamazaki T. and Takeshima H
    • Journal Title

      Pharmacol. Therapeut 121

      Pages: 265-272

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes2009

    • Author(s)
      Masumiya H., Asaumi Y., Nishi M., Minamisawa S., Adachi-Akahane S., Yoshida M., Kangawa K., Ito K., Kagaya Y., Yanagisawa T., Yamazaki T. , Ma J. and Takeshima H
    • Journal Title

      Channels 3

      Pages: 6-11

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitsugumin 53-mediated maintenance of K+ currents incardiac myocytes2009

    • Author(s)
      Masumiya H.
    • Journal Title

      Channels 3

      Pages: 6-11

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New molecular components supporting ryanodine receptor-mediated Ca2+ release : roles of junctophilin and TRIC channel in embryonic cardiomyocyes2009

    • Author(s)
      Yamazaki D.
    • Journal Title

      Pharmacol. Ther. 121

      Pages: 265-272

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced NK-cell development and function in BCAP-deficient mice2008

    • Author(s)
      MacFarlane IV AW., Yamazaki T., Fang M., Sigal LJ., Kurosaki T. and Campbell KS
    • Journal Title

      Blood 112

      Pages: 131-140

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of B cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase2008

    • Author(s)
      Aiba Y., Kameyama M., Yamazaki T., Tedder TF. And Kurosaki T
    • Journal Title

      Blood 111

      Pages: 1497-150

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of B cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase2008

    • Author(s)
      Aiba Y.
    • Journal Title

      Blood 111

      Pages: 1497-1503

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced NK-cell development and function in BCAP-deficient mice2008

    • Author(s)
      MacFarlane IV AW.
    • Journal Title

      Blood 112

      Pages: 131-140

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins. Biochem. Biophys. Res2007

    • Author(s)
      Ikeda A., Miyazaki T., Kakizawa S., Okuno Y., Tsuchiya S., Myomoto A., Saito S., Yamamoto T., Yamazaki T., Iino M., Tsujimoto G., Watanabe M. and Takeshima H
    • Journal Title

      Commun 363

      Pages: 835-839

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Augmentation of drug-induced cell death by ER protein BRI3BP. Biochem. Biophys. Res2007

    • Author(s)
      Yamazaki T. , Sasaki N., Nishi M., Yamazaki D., Ikeda A., Okuno Y., Komazaki S. and Takeshima H
    • Journal Title

      Commun 362

      Pages: 971-975

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calumin, a novel Ca2+ -binding protein on the endoplasmic reticulum2007

    • Author(s)
      Zhang M., Yamazaki T. , Yazawa M., Treves S., Nishi M., Murai M., Shibata E., Zorzato F. and Takeshima H
    • Journal Title

      Cell Calcium 42

      Pages: 83-90

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calumin, a novel Ca2+-binding transmembrane protein on the endoplasmic reticulum.2007

    • Author(s)
      Zhang, M.
    • Journal Title

      Cell Calcium 42

      Pages: 83-90

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Augmentation of drug-induced cell death by ER protein BRI3BP2007

    • Author(s)
      Yamazaki, T.
    • Journal Title

      Biochem Biophys Res Commun. 362

      Pages: 971-975

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.2007

    • Author(s)
      Ikeda, A.
    • Journal Title

      Biochem Biophys Res Commun. 363

      Pages: 835-839

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 小胞体蛋白質MG23を介した小胞体発シグナルと細胞死2007

    • Author(s)
      山崎 哲男
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Book] 医歯薬系学生のためのillustrated基礎生命科学2008

    • Author(s)
      竹島浩、山崎哲男、池田篤史、輿水崇鏡
    • Publisher
      京都廣川書店
    • Related Report
      2008 Final Research Report
  • [Book] 医歯薬系学生のためのillustrated基礎生命科学2008

    • Author(s)
      竹島浩
    • Total Pages
      241
    • Publisher
      京都廣川書店
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-03-31   Modified: 2016-04-21  

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