CharaGterization of the evoked inflammation via hypoxic response in endothelial cells
| Project/Area Number |
19590281
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TOMITA Tomita The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 (00263898)
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| Co-Investigator(Kenkyū-buntansha) |
TAMAKI Tamaki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (80179879)
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| Research Collaborator |
ISHIZAWA Ishizawa 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (60398013)
URATA Urata 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 大学院生
FUKUHARA Yayoi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 大学院生
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 高次生命医学 / 血管内皮細胞 / 低酸素応答 / 炎症反応 / 転写因子 / Hypoxia Inducible Factor / 肺性高血圧 / 血管平滑筋細胞 / 炎症細胞 |
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| Research Abstract |
生体が低酸素環境に曝されたときには、生体の主要な酸素供給経路に位置する血管内皮細胞(EC)は、様々な病態疾患に伴う低酸素応答の仲介役的存在であると考えられる。研究代表者らは、ECに発現する低酸素応答性転写因子ARNT遺伝子を欠失させたマウスを作製・利用することにより、生体内の炎症に細胞内低酸素応答がどのように関与するのかを解析した。その結果、ECの低酸素応答は、生体の炎症惹起に寄与している可能性が示された。
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Report
(3 results)
Research Products
(66 results)
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[Journal Article] Gene expression profile of third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus develoPment2009
Author(s)
Sultana DA, Tomita S, Hamada M, Itisanaga Y, Kitahama Y, Nguyen VK, Hirai S, Ohigashi I, Nitta S, Amagai T, Takahashi S and Takahama Y(*These two authors equally contributed to this work.)
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Journal Title
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Peer Reviewed
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[Journal Article] Law-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the arylhydrocarbon receptor-mediated pathway inmouse liver2008
Author(s)
Sato, S., Shirakawa, H., Tomita, S., Ohsaki, Y., Haketa, K., Tooi, 0., Santo, N., Tohkin, M., Furukawa, Y., Frank J. Gonzalez and Kamai, M
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Journal Title
Toaicol Appl Pharmacol 229
Pages: 10-19
Related Report
Peer Reviewed
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[Journal Article] Dietary doses of nitrite restore the circulating nitricoxide level and improve renal injury in L-NAME-induced hypertensive rats2008
Author(s)
Kanematsu Y, Yamaguchi K, Ohnishi H, Motohayashi Y, Ishizawa K, Izawa Y, Katvazoe K, Kondo S, Kagami S, Tomita S, Tsuchiya K and Tamaki T
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Journal Title
AmJ Physiol Renal Physiol 295
Related Report
Peer Reviewed
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[Journal Article] Effect of iron-quercetin complex on reduction of nitrite in vitro and in vivo system2008
Author(s)
Ohnishi H, Iwanaga S, Kawazoe K, Ishizawa K, Orino S, Tomita S, Tsuchiya K, Kanematsu Y, Harada N, Mori K, Ishikawa Y and Tamaki T
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Journal Title
J Agric Food Chem 56
Pages: 10092-10108
Related Report
Peer Reviewed
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[Journal Article] p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload2007
Author(s)
Sano M, Minamino T, Toko H, Miyauchi H, Orima M, Qin Y, AkazaNa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y and Komuro I
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Journal Title
Nature 446
Pages: 444-448
Related Report
Peer Reviewed
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[Presentation] Hypoxia-inducible factor-la is a tumor suppressor in early stages in a mouse model of multi-step islet carinogenesis. Keystone Symposia(Molecular, Cellular, Physiological, and Pathogenic Responses to Hypoxia2008
Author(s)
Inoue, M., Takeda, T., Endo, H., Tomita, S.
Organizer
Vancouver
Place of Presentation
British Columbia
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[Presentation] Hif-la in T cells plays a crucial role in the progression of arteriosclerosis and artery intimal thickening2007
Author(s)
Kuorabe, H., Urata, M., Izawa, Y., Fukuhara, Y., Kanbara, T., Aihara, K.I., Akaike, M., Gonzalez, F., Matsumoto, T., Tamaki, T., Kitagawa, T., Yoshizumi, M., Tomita, S
Organizer
AHA Scientific Sessions
Place of Presentation
Orlando, Florida
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