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Cell characteristic analysis in cultured human neural stem cells and development of the evaluation system

Research Project

Project/Area Number 19590287
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionKeio University

Principal Investigator

YASUO Nagai  Keio University, 医学部, 助教 (10425704)

Co-Investigator(Kenkyū-buntansha) MATSUZAKI Yumi  慶應義塾大学, 医学部, 准教授 (50338183)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords再生医学 / 神経幹細胞 / 分化
Research Abstract

本研究は、高率に神経へ分化する神経幹細胞のマーカーを同定することによって分化傾向の違う神経幹細胞の精製を目指した。ヒト神経幹細胞を様々な細胞表面特異的抗原に対するモノクローナル抗体で染色後、サブポピュレーションをフローサイトメーターにより分離した。また、CD133陽性ヒト神経幹細胞の中でもCD24 陰性細胞が、CD24陽性細胞やフローサイトメーターで分離していない細胞に比べて自己増殖能に優れていることを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (5 results)

All 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (1 results)

  • [Journal Article] Development of mesenchymal stem cells partially originate from the neural crest.2009

    • Author(s)
      Morikawa S, Mabuchi Y, Niibe K, Suzuki S, Nagoshi N, Sunabori T, Shimmura S, Nagai Y, Nakagawa T, Okano H, Matsuzaki Y.
    • Journal Title

      Biochem Biophys Res Commun. 379(4)

      Pages: 1114-1119

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of mesenchymal stem cells partially originate from the neural crest.2009

    • Author(s)
      Satoru Morikawa, et al.
    • Journal Title

      Biochem Biophys Res Commun 379(4)

      Pages: 1114-1119

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad2008

    • Author(s)
      Nagoshi N, Shibata S, Kubota Y, Nakamura M, Nagai Y, Satoh E, Morikawa S, Okada Y, Mabuchi Y, Katoh H, Okada S, Fukuda K, Suda T, Matsuzaki Y, Toyama Y, Okano H.
    • Journal Title

      Cell Stem Cell. 2(4)

      Pages: 392-403

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad.2008

    • Author(s)
      Narihito Nagoshi, et al.
    • Journal Title

      Cell Stem Cell 2(4)

      Pages: 392-403

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effect of low oxygen environment on cultured human fetal neural stem/progenitor cells2008

    • Author(s)
      Yasuo Nagai
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report 2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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