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Elucidation of the significance of MAPK-dependent MITF activation in melanoma

Research Project

Project/Area Number 19590321
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionKeio University

Principal Investigator

SUMIMOTO Hidetoshi  Keio University, 医学部, 助教 (00306838)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
KeywordsMITF / BRAF / MAPK / melanoma / DNA microarray / 悪性黒色腫 / RNAi / DNAマイクロアレイ / 分子標的 / HIVベクター
Research Abstract

悪性黒色腫細胞で活性化の見られる二種類の癌遺伝子、BRAFとMITFを標的化する治療法の有用性を検討した。各単独の抑制で細胞増殖抑制効果に対して耐性を示す複数の悪性黒色腫細胞株において、両者を同時に抑制することでより強力な抑制効果を認めた。DNAマイクロアレイ解析により、両者の遺伝子により個別にまたは共通に発現制御を受ける遺伝子発現プロフィールを作製し、悪性黒色腫に対する新規分子標的の候補を得た。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (38 results)

All 2009 2008 2007

All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (25 results) Book (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Tumor growth suppression by adenovirus-mediated introduction of a cell growth suppressing gene tob in a pancreatic cancer model.2009

    • Author(s)
      Yanagie H, Sumimoto H, et al.
    • Journal Title

      Biomed Pharmacother. 63

      Pages: 275-286

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor growth suppression by adenovirus-mediated introduction of a cell growth suppressing gene tob in a pancreatic cancer model2008

    • Author(s)
      Yanagie H, Tanabe T, Sumimoto H, Sugiyama H, Matsuda S, Nonaka Y, Ogiwara N, Sasaki K, Tani K, Takamoto S, Takahashi H, Eriguchi M.
    • Journal Title

      Biomed Pharmacother Epubahead of print

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dendritic cell based personalized immunotherapy based on cancer antigen research2008

    • Author(s)
      Kawakami Y, Fujita T, Kudo C, Sakurai T, Udagawa M, Yaguchi T, Hasegawa G, Hayashi E, Ueda Y, Iwata T, Wang Q, Okada S, Tsukamoto N, Matsuzaki Y, Sumimoto H.
    • Journal Title

      Frontiers in Bioscience 1;13

      Pages: 1952-1958

    • Related Report
      2008 Final Research Report
  • [Journal Article] Takayanagi A, Miyashita K, Akao M, Tabata M, Tamiya G, Ohkura T, Hibi T. Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice2008

    • Author(s)
      Tomita K, Oike Y, Teratani T, Taguchi T, Noguchi M, Suzuki T, Mizutani A, Yokoyama H, Irie R, Sumimoto H
    • Journal Title

      Hepatology 48

      Pages: 458-473

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice.2008

    • Author(s)
      Tomita K, Sumimoto H, et al.
    • Journal Title

      Hepatology 48

      Pages: 458-73

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of individualized immunotherapy based on the analysis on anti-tumor immune responses to the human tumor antigens identified using immunological and genetic methods2007

    • Author(s)
      Kawakami Y, Fujita T, Kudo C, Sakurai T, Udagawa M, Hasegawa G, Ishida A, Kitagawa Y, Tanabe M, Saito M, Izumi Y, Kawamura M, Yaguchi T, Ueda Y, Hayashi E, Wang Q, Okada S, Tsukamoto N, Matsuzaki Y, Sumimoto H, Takeuchi H, Tanikawa A, Handa M, Amagai M, Kobayashi K, Ikeda Y, Azuma I, Kitajima M.
    • Journal Title

      Gene Therapy 2007

      Pages: 240-248

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lentiviral vector-mediated RNAi and its use for cancer research2007

    • Author(s)
      Sumimoto H and Kawakami Y.
    • Journal Title

      Future Oncol 3(6)

      Pages: 655-664

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] メラノーマ細胞の免疫回避機構2007

    • Author(s)
      住本秀敏
    • Journal Title

      臨床免疫・アレルギー科 vol.47, No.3

      Pages: 361-366

    • NAID

      40015423626

    • Related Report
      2008 Final Research Report
  • [Journal Article] Lentiviral vector-mediated RNAi and its use for cancer research2007

    • Author(s)
      Sumimoto H, Kawakami Y
    • Journal Title

      Future Oncology 3

      Pages: 655-664

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒト悪性黒色腫細胞株によるヒト単球由来MDSC様サブセットの誘導2008

    • Author(s)
      山本夏啓、住本秀敏、川村直、梅澤一夫、河上裕
    • Organizer
      第38回日本免疫学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-02
    • Related Report
      2008 Final Research Report
  • [Presentation] 癌細胞におけるMAPKシグナル亢進による腫瘍免疫逃避機構の解明/2008

    • Author(s)
      谷口智憲、木藤健治、塚本信夫、桜井敏晴、藤田知信、持丸博史、丸山正太郎、里見良輔、井田陽介、住本秀敏、河上裕
    • Organizer
      Roles of activated MAPK pathway in generation of immunosuppressive microenvironment by the production of immunosuppressive cytokines from various cancers
    • Place of Presentation
      京都
    • Year and Date
      2008-12-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Immunosuppression by human melanomavia activated Wnt/beta-catenin signaling. (Wnt/beta-cateninシグナル亢進による悪性黒色種の免疫逃避機構の解明)2008

    • Author(s)
      谷口智憲、木藤健治、塚本信夫、桜井敏晴、持丸博史、丸山正太郎、里見良輔、井田陽介、住本秀敏、河上裕
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] Use of cultured dendritic cells for immunotherapy of cancer. (培養樹状細胞を用いた免疫療法)2008

    • Author(s)
      河上裕、住本秀敏、工藤千恵、塚本信夫、藤田知信、桜井敏晴、谷口智憲、岩田知子、川村直
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] MCL-1 knockdown enhances 5-FU-INDUCED apoptosis in side poplation (SP) cells of gastric cancer cells. (胃癌細胞株の幹細胞におけるMyeloid cell Leukemia-1 (Mcl-1)蛋白阻害によるアポトーシス増強作用の検討)2008

    • Author(s)
      飯塚秀子、樋口肇、住本秀敏、樺島彩乃、酒井元、泉谷幹子、山岸由幸、高石官均、河上裕、水口裕之、日比紀之
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 癌シグナル伝達異常による癌免疫逃避機構の解析2008

    • Author(s)
      谷口智憲、木藤健治、丸山正太郎、住本秀敏、河上裕
    • Organizer
      第28回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-08-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Molecular mechanismis for immuno-suppression induced by melanoma cells2008

    • Author(s)
      Yutaka Kawakami, Hidetoshi Sumimoto, Chie Kudo, Nobuo Tsukamoto, Tomonori Yaguchi
    • Organizer
      20th International Pigment Cell Conference & 5th International Melanoma Research Congress
    • Place of Presentation
      Sapporo
    • Year and Date
      2008-05-12
    • Related Report
      2008 Final Research Report
  • [Presentation] siRNAライブラリーを用いた癌免疫回避シグナルの同定2008

    • Author(s)
      川村直、住本秀敏、河上裕
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] siRNAライブラリーを用いた癌免疫回避シグナルの同定2008

    • Author(s)
      川村直、住本秀敏、河上裕
    • Organizer
      第12回基盤的癌免疫研究会
    • Place of Presentation
      大宮、埼玉
    • Related Report
      2008 Final Research Report
  • [Presentation] si-RNAライブラリーを用いた癌免疫回避シグナルの同定2008

    • Author(s)
      川村直, 住本秀敏, 河上裕
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular mechanisms for generation of immunosuppressive microenvironment by cancer cells2007

    • Author(s)
      Yutaka Kawakami, Hidetoshi Sumimoto, Chie Kudo, Tomonori Yaguchi
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Induction of high IL10 producing DC by melanoma cells with altered Wnt/beta -catenin signaling2007

    • Author(s)
      Tomonori Yaguchi, Kenji Kido, Nobuo Tsukamoto, Hiroshi Mochimaru, Shotaro Maruyama, Ryosuke Satomi, Hidetoshi Sumimoto, Yutaka Kawakami
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Possible inhibition of TLR signaling by PI3K through preventing PIP2-associated TIRAP recruitment to plasma cell membrane in human dendritic cells2007

    • Author(s)
      Sumimoto, H., Takahashi, T., Kawakami, Y.
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2008 Final Research Report
  • [Presentation] MITF protein levels determine the proliferation status of melanoma cells2007

    • Author(s)
      Sumimoto H, et. al.
    • Organizer
      The 4th International Melanoma Congress
    • Place of Presentation
      New York,USA
    • Year and Date
      2007-11-03
    • Related Report
      2007 Annual Research Report
  • [Presentation]2007

    • Author(s)
      Yutaka Kawakami, Tomonobu Fujita, Chie Kudo, Masaru Udagawa, Toshiharu Sakurai, Yoko Ueda, Tomonori Yaguchi, Hidetoshi Sumimoto
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Related Report
      2008 Final Research Report
  • [Presentation] MCL-1 depletion by adenoviral-mediated short hairpin RNA enhances apoptosis sensitivity in gastrointestinal cancer cells2007

    • Author(s)
      Hideko Iizuka, Hajime Higuchi, Hidetoshi Sumimoto, Ayano Kabashima, Naoko Kuriyama, Gen Sakai, Motoko Izumiya, Yoshiyuki Yamagishi, Hiromasa Takaishi, Yutaka Kawakami, Hiroyuki Mizuguchi, Toshifumi Hibi
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Related Report
      2008 Final Research Report
  • [Presentation] The proliferation of melanoma cells depends on the protein levels of MITF2007

    • Author(s)
      住本秀敏、木藤健治、浅田咲世、岡田スターリン、谷口智憲、斎田俊雄、河上裕
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] The proliferation of melanoma cells depends on the protein levels of MITF2007

    • Author(s)
      Sumimoto H, et. al.
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama,Japan
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of Wnt/beta-catenin Signaling Pathway in Production of an Immunosuppressive Cytokine, IL10, by Melanoma Cells : Possible Mechanisms for Cancer Immunoescape2007

    • Author(s)
      谷口智憲、木藤健治、塚本信夫、持丸博史、丸山正太郎、住本秀敏、河上裕
    • Organizer
      第11回基盤的癌免疫研究会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-11
    • Related Report
      2008 Final Research Report
  • [Presentation] MCL-1 depletion sensitizes the apoptosis of gastrointestinal cancer cells mediated by anti-cancer drugs2007

    • Author(s)
      Hideko Iizuka, Hajime Higuchi, Hidetoshi Sumimoto, Ayano Kabashima, Naoko Kuriyama, Gen Sakai, Motoko Izumiya, Yoshiyuki Yamagishi, Hiromasa Takaishi, Yutaka Kawakami, Hiroyuki Mizuguchi, Toshifumi Hibi
    • Organizer
      13th International Congress of Mucosal Immunology
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-07-11
    • Related Report
      2008 Final Research Report
  • [Presentation] Immunotherapy and gene therapy using viral vectors2007

    • Author(s)
      Yutaka Kawakami, Masaru Udagawa, Kenji Kido, Tomonori Yaguchi, Masahiro Toda, Chie Kudo, Hidetoshi Sumimoto
    • Organizer
      The 13^<th> annual meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-06-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Enhancement of human monocyte-derived dendritic cell functions by adenovirus-mediated RNA interference of STAT-32007

    • Author(s)
      Iwata, T., Sumimoto, H., Mizuguchi, H., Kawakami, Y.
    • Organizer
      The 13^<th> annual meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-06-30
    • Related Report
      2008 Final Research Report
  • [Presentation] MITF protein levels determine the proliferation status of melanoma cells2007

    • Author(s)
      Kido, K., Sumimoto, H., Asada, S., Okada, S. M., Yaguchi, T., Saida, T., Kawakami, Y.
    • Organizer
      The 13^<th> annual meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-06-30
    • Related Report
      2008 Final Research Report
  • [Presentation] レンチウイルスshRNAを用いたMITF発現抑制による悪性黒色腫細胞の増殖・浸潤の抑制2007

    • Author(s)
      木藤健治、住本秀敏、浅田咲世、岡田スターリン、谷口智憲、斎田俊明、河上裕
    • Organizer
      日本研究皮膚科学会第32回年次学術大会・総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-04-20
    • Related Report
      2008 Final Research Report
  • [Presentation] MITF protein levels determine the proliferation status of melanoma cells2007

    • Author(s)
      Sumimoto, H., Kido, K., Asada, S., Okada, S. M., Yaguchi, T., Saida, T., Kawakami, Y.
    • Organizer
      The 4^<th> International Melanoma Congress
    • Place of Presentation
      New York, USA
    • Related Report
      2008 Final Research Report
  • [Book] Chapter 13. The RNA silencing technology applied by lentiviral vectors in oncology. Lentivirus Gene Engineering Protocols. the 2nd edition2009

    • Author(s)
      Hidetoshi Sumimoto and Yutaka Kawakami
    • Publisher
      Human Press Ed. (in press)
    • Related Report
      2008 Final Research Report
  • [Book] Chapter 13. The RNA silencing technology applied by lentiviral vectors in oncology. Lentivirus Gene Engineering Protocols, the 2^<nd> edition2009

    • Author(s)
      Sumimoto H, Kawakami Y.
    • Publisher
      Human Press(in press)
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗腫瘍剤2008

    • Inventor(s)
      住本秀敏、川村直、河上裕
    • Industrial Property Rights Holder
      慶應義塾大学
    • Industrial Property Number
      2008-166291
    • Filing Date
      2008-06-25
    • Related Report
      2008 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 抗腫瘍剤2008

    • Inventor(s)
      住本秀敏, 川村直, 河上裕
    • Industrial Property Rights Holder
      慶應義塾大学
    • Industrial Property Number
      2008-166291
    • Filing Date
      2008-06-25
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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