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Human Y-box binding protein1(YB-1) : Mechanism for the nuclear translocation and its role of tumor growth and drug resistance-

Research Project

Project/Area Number 19590324
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionKyushu University (2008)
Kurume University (2007)

Principal Investigator

KUWANO Michihiko  Kyushu University, 先端融合医療レドックスナビ研究拠点, 特任教授 (80037431)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsYB-1 / YB-1核内局在 / 多剤耐性 / EGF受容体ファミリー / 乳癌 / P-糖蛋白質 / MVP / LRP / エストラジオール受容体 / 核内局在 / 癌増殖 / EGF受容体 / がんバイオマーカー / Aktシグナル
Research Abstract

我々はがん治療後のP-糖蛋白質(ABCB1)依存性多剤耐性がんの発現にY-ボックス結合蛋白-1(YB-1)が深く関与することをはじめて発見した。本研究では、増殖シグナルによるYB-1 の核内移行にP13k/Akt による活性化が必要であり、多くのヒトがん細胞の増殖を制御し、YB-1 の核内局在がヒト卵巣癌、乳癌や軟部腫瘍などにおいて耐性および増殖関連遺伝子の発現や患者の予後と有意に相関することなどを見出した。以上、YB-1 はがん治療の有用なバイオマーカーであると確信している。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (69 results)

All 2009 2008 2007 Other

All Journal Article (49 results) (of which Peer Reviewed: 49 results) Presentation (18 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] M.N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of IKKbeta expression2009

    • Author(s)
      Hosoi, F., Izumi, H., Kawahara, A., Yuichi, M., Kinoshita, H., Kage, M., Nishio, K., Kohno, K., Kuwano, M., and Ono
    • Journal Title

      Cancer Res. 69

      Pages: 4983-4991

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Higher expression of deoxyuridinetriphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer2009

    • Author(s)
      Kawahara, A., Akagi, Y., Hattori, S., Mizobe, T., Shirouzu, K., Ono, M., Yanagawa, T., Kuwano, M and Kage, M
    • Journal Title

      J.Clinic. Pathology 62

      Pages: 364-369

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of class III・-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma2009

    • Author(s)
      Aoki, D., Oda, Y., Hattori, S., Taguchi, K., Ohishi, Y., Basaki, Y., Oie, S., Suzuki, N., Kono, S., Tsuneyoshi, M., Ono, M., Kuwano, M
    • Journal Title

      Clinic.Cancer Res. 15

      Pages: 1473-1480

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of class III β-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma.2009

    • Author(s)
      Aoki, D., et. al
    • Journal Title

      Clinic. Cancer Res. 15

      Pages: 1473-1480

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher expression of deoxyuridinetriphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer2009

    • Author(s)
      Kawahara, A., et. al
    • Journal Title

      J. Clinic. Pathology 62

      Pages: 364-369

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of macrophages in inflammatory . lymphangiogenesis : Enhanced production of vascular endothelial growth factor C and Dthrough NF-κB activation2008

    • Author(s)
      Watari, K., Nakao, S., Fotovati, A., Basaki, Y., Hosoi, F., Bereczky, B., Higuchi, R. Miyamoto, T., Kuwano, M., and Ono
    • Journal Title

      Biochem. Biophys. Res. Commun. 377

      Pages: 826-831

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth inhibitory effects of pegylated IFN-alpha2b and5-fluorouracil in combination on renal cell carcinoma cell lines in vitro and in vivo2008

    • Author(s)
      Moriya, F., Ogasawara, S., Basaki, Y., Akiba, J., Kojiro, S., Fukahori, S., Ishizaki, H., Nishida, N., Matsuoka, K., Kojiro, M., Kuwano, M., and Yano, H
    • Journal Title

      Int. J. Oncol. 33

      Pages: 647-655

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular basis for the induction of an angiogenesis inhibitor thrombospondin-1, by 5-fluorouracil2008

    • Author(s)
      Zhao, H., Ooyama, A., Yamamoto, M., Ikeda, R., Haraguchi, M., Tabata, S., Furukawa, T., Che, X., Zhang, S., Oka, T., Fukushima, M., Nakagawa, M., Ono, M., Kuwano, M., and Akiyama, S
    • Journal Title

      Cancer Res. 68

      Pages: 7035-7041

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells2008

    • Author(s)
      Zhao, H., Ooyama, A., Yamamoto, M., Ikeda, R., Haraguchi, M., Tabata, S., Furukawa, T., Che, X., Iwashita, K., Oka, T., Fukushima, M., Nakagawa, M., Ono, M., Kuwano, M., and Akiyama, S
    • Journal Title

      Cancer Lett. 270

      Pages: 156-163

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of bone and muscle metastases of lung cancer cells by decrease in the number of monocytes/macrophages2008

    • Author(s)
      Hiraoka, K., Zenmyo, M., Watari, K., Iguchi, H., Fotovati, A., Kimura, Y., Hosoi, F., Shoda, T., Nagata, K., Osada, H., Ono, M., and Kuwano, M
    • Journal Title

      Cancer Sci. 99

      Pages: 1595-1602

    • NAID

      10024009829

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different expression profiles of Y-box-binding protein-1 and multidrug resistance-associated proteins between alveolar and embryonal rhabdomyosarcoma2008

    • Author(s)
      Oda, Y., Kohashi, K., Yamamoto, H., Tamiya, S., Kohno, K., Kuwano, M., Iwamoto, Y., Tajiri, T., Taguchi, T., and Tsuneyoshi, M
    • Journal Title

      Cancer Sci. 99

      Pages: 726-732

    • NAID

      10024004844

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preclinical and clinical studies of novel breast cancer drugs targeting molecules involved in protein kinase C signaling, the putative metastasis-suppressor gene Cap43 and the Y-box binding protein-12008

    • Author(s)
      Fujii, T., Yokoyama, G., Takahashi, H., Toh, U., Kage, M., Ono, M., Shirouzu, K., and Kuwano, M
    • Journal Title

      Current Medicinal Chem. 15

      Pages: 528-537

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preclinical studies of molecular-targeting diagnostic and therapeutic strategies against breast cancer2008

    • Author(s)
      Fujii, T., Yokoyama, G., Takahashi, H., Namoto, R., Nakagawa, S., Toh, U., Kage, M., Shirouzu, K., and Kuwano, M
    • Journal Title

      Breast Cancer 15

      Pages: 73-78

    • NAID

      10021288533

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ets Transcription factors regulate peroxiredoxin1 and peroxiredoxin5 expression through their interaction with the high mobility group protein HMGB12008

    • Author(s)
      Shiota, M., Izumi, H., Miyamoto, N., Onitsuka, T., Kashiwagi, E., Kidani, A., Hirano, G., Ono, M., Kuwano, M., Naito, S., Sasaguri, Y., and Kohno, K
    • Journal Title

      Cancer Sci. 99

      Pages: 1950-1959

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cap43/NDRG1/Drg-1 is a molecular target for angiogenesis and a prognostic indicator in cervical adenocarcinoma2008

    • Author(s)
      Nishio, S., Tsuda, N., Takemoto, S., Kawano, K., Ushijima, K., Yamaguchi, T., Nishida, N., Kakuma, T., Tsuda, H., Kasamatsu, T., Sasajima, Y., Kage, M., Kuwano, M., and Kamura , T
    • Journal Title

      Cancer Lett. 264

      Pages: 36-43

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutant MCP-1 therapy inhibits tumor angiogenesis and growth of malignant melanoma in mice2008

    • Author(s)
      Koga, M., Kai,H., Egami, K., Murohara, T., Ikeda, A., Yasuoka, S.,Egashira, K., Matsuishi, T., Kai, M., Kataoka, Y., Kuwano, M., and Imaizumi, T
    • Journal Title

      Biochem. Biophys. Res. Commun. 365

      Pages: 279-284

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of HER2 and estrogen receptor alpha depends upon nuclear localization of Y-box binding protein-1 in human breast cancers2008

    • Author(s)
      Fujii, T., Kawahara, A., Basaki, Y., Hattori, S., Nakashima, K., Nakano, K., Shirouzu, K., Kohno, K., Yanagawa, T., Yamana, H., Nishio, K., Ono, M., Kuwano, M., and Kage, M
    • Journal Title

      Cancer Res. 68

      Pages: 1504-1512

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of HER2 and estrogen receptor alpha depends up on nuclear localization of Y-box binding protein-1 in human breast cancers.2008

    • Author(s)
      Fujii, T., et. al
    • Journal Title

      Cancer Res. 68

      Pages: 1504-1512

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutant MCP-1 therapy inhibits tumor angiogenesis and growth of malignant melanoma in mice.2008

    • Author(s)
      Koga, M., et. al
    • Journal Title

      Biochem. Biophys. Res. Commun. 365

      Pages: 279-284

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cap43/NDRG1/Drg-1 is a molecular target for angiogenesis and aprognostic indicator in cervical adenocarcinoma.2008

    • Author(s)
      Nishio, S., et. al
    • Journal Title

      Cancer Lett. 264

      Pages: 36-43

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ets Transcription factors regulate peroxiredoxinl and peroxiredoxin5 expression through their interaction with the high mobility group protein HMGB1.2008

    • Author(s)
      Shiota, M., et. al
    • Journal Title

      Cancer Sci. 99

      Pages: 1950-1959

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preclinical studies of molecular-targeting diagnostic and therapeutic strategies against breast cancer.2008

    • Author(s)
      Fujii, T., et. al
    • Journal Title

      Breast Cancer 15

      Pages: 73-78

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preclinical and clinical studies of novel breast cancer drugs targeting molecules involved in protein kinase C signaling, the putative metastasis-suppressor gene Cap43 and the Y-box binding protein-1.2008

    • Author(s)
      Fujii, T., et. al
    • Journal Title

      Current Medicinal Chem. 15

      Pages: 528-537

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different expression profiles of Y-box-binding protein-1 and multidrug resistance-associated proteins between alveolar and embryonal rhabdomyosarcoma.2008

    • Author(s)
      Oda, Y., et. al
    • Journal Title

      Cancer Sci. 99

      Pages: 726-732

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of bone and muscle metastases of lung cancer cells by decrease in the number of monocytes/macrophages.2008

    • Author(s)
      Hiraoka, K., et. al
    • Journal Title

      Cancer Sci. 99

      Pages: 1595-1602

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells.2008

    • Author(s)
      Zhao, H., et. al
    • Journal Title

      Cancer Lett. 270

      Pages: 156-163

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular basis for the induction of an angiogenesisinhibitor, thrombospondin-1, by 5-fluorouracil.2008

    • Author(s)
      Zhao, H., et. al
    • Journal Title

      Cancer Res. 68

      Pages: 7035-7041

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth inhibitory effects of pegylated IFN-alpha2b and 5-fluorouracil in combination on renal cell carcinoma cell lines in vitro and in vivo.2008

    • Author(s)
      Moriya, F., et. al
    • Journal Title

      Int. J. Oncol. 33

      Pages: 647-655

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of macrophages in inflammatory lymphangiogenesis : Enhanced production of vascular endothelial growth factor C and D through NF-κB activation.2008

    • Author(s)
      Watari, K., et. al
    • Journal Title

      Biochem. Biophys. Res. Commun. 377

      Pages: 826-831

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-myc downstream regulated genel (NDRG1)/Cap43enhances portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma.2008

    • Author(s)
      Akiba, J., et. al
    • Journal Title

      Oncology Report. 20

      Pages: 1329-1335

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] がん化学療法のおり方-基礎医学の立場から2008

    • Author(s)
      桑野信彦
    • Journal Title

      癌の臨床 54

      Pages: 239-245

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutant MCP-I therapy inhibits tumor angiogenesis and growth of maliant melalloma in mice2008

    • Author(s)
      Koga, M.
    • Journal Title

      Biochem.Biophys.Res.Commun 365

      Pages: 279-284

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis2007

    • Author(s)
      Kimura, Y., Watari, K., Fotovati, A., Hosoi, F., Yasumoto, K., Izumi, H., Kohno, K., Umezawa, K., Iguchi, H., Shirouzu, K., Takamori, S., Kuwano, M.,and Ono,M
    • Journal Title

      Cancer Sci. 98

      Pages: 2009-2018

    • NAID

      10019996850

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression profile of class I histone deacetylases in human cancer tissues2007

    • Author(s)
      Nakagawa, M., Oda, Y., Eguchi, T., Aishima, S., Yao, T., Hosoi, F., Basaki, Y., Ono, M., Kuwano, M., Tanaka, M., and Tsuneyoshi, M
    • Journal Title

      Oncology Rep. 18

      Pages: 769-774

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical expression of Cap43 and Mina53 proteins in neuroblastoma2007

    • Author(s)
      Fukahori, S., Yano, H., Tsuneoka, M., Tanaka, Y., Yagi, M., Kuwano, M., Tajiri, T., Taguchi, T., Tsuneyoshi, M., and Kojiro, M
    • Journal Title

      J Pediatric Surgery 42

      Pages: 1831-1840

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dexamethasone inhibits IL-1b-induced corneal neovascularization : role of NF-kB-activated stromal cells in inflammatory angiogenesis2007

    • Author(s)
      Nakao, S., Hata, Y., Miura, M., Noda, K., Kimura, Y., Kawahara, S., Kita, T., Hisatomi, T., Nakazawa, T., Jin, Y., Dana, R., Kuwano, M., Ono, M., Ishibashi, T. and Hafezi-Moghadam, A
    • Journal Title

      Am. J. Path. 171

      Pages: 1058-1065

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of dihydropyrimidine dehydrogenase expression by interferon-・ affects the antiproliferative effects of 5-fluorouracil in human hepatocellular carcinoma cells2007

    • Author(s)
      Oie, S., Ono M., Fukushima, H., Hosoi, F., Yano, H., Maruyama Y., Kojiro, M., Terada, T., Hirano K., Kuwano M., and Yamada, Y
    • Journal Title

      Molec. Cancer Therapeut. 6

      Pages: 2310-2318

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of beta-tubulin isotypes in human primary ovarian carcinoma2007

    • Author(s)
      Ohishi, Y., Oda, Y., Basaki, Y., Kobayashi, H., Wake, N., Kuwano, M.,c and Tsuneyoshi, M
    • Journal Title

      Gynecol. Oncol 105

      Pages: 586-592

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic inmlication of nuclear localization of the Y-box-binding protein-1 and CXC4 expression in ovarian cancer : Their correlation with activated Akt, LRP/MVP and P-glycoprotein expression2007

    • Author(s)
      Oda, Y., Ohishi, Y., Basaki, Y., Kobayashi, H., Hirakawa, T., Wake, N., Ono, M, Nishio, K, Kuwano, M
    • Journal Title

      Cancer Sci. 98

      Pages: 1020-1026

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Akt-dependent nuclear localisation of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells2007

    • Author(s)
      Basaki, Y., Hosoi, F., Oda, Y., Fotovati, A., Maruyama, Y., Oie, S., Ono, M., Izumi, H., Kohno, K.,Shimoyama, T., Nishio, K., and Kuwano M
    • Journal Title

      Oncogene 26

      Pages: 2736-2746

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Akt-dependent nuclear Iocalisation of Y-box-binding Protein lin acquisition of malignant characteristics by human ovarian cancer cells2007

    • Author(s)
      Basaki, Y.
    • Journal Title

      Oncogene 26

      Pages: 2736-2746

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic inmlication of nuclear localization of the Y-box-binding protein-1 and CXC4 expression in ovarian cancer:Their correlation with activated Akt,LRP/MVP and P-glycoproteln exression2007

    • Author(s)
      Oda, Y.
    • Journal Title

      Cancer Sci 105

      Pages: 586-592

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of beta-tubulill isotypes in human primary ovarian carclnoma2007

    • Author(s)
      Ohishi, Y
    • Journal Title

      Gynecol.Oncol 6

      Pages: 2310-2318

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of dihydropyrimidine dehydrogellase expression by interferon-口 affects the antiproliferative effects of 5-fluorouracil in human heatocellular carcinoma cells2007

    • Author(s)
      Oie, S.
    • Journal Title

      Molec.Cancer Therapeut 6

      Pages: 2310-2318

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A.Dexamethasolle inhibits IL-1b-induced comeal neovascularization:role of NF-kB-activated stromal cells in inflammator anloenesls2007

    • Author(s)
      Nakao, S.
    • Journal Title

      Am.J.Path 171

      Pages: 1058-1065

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochelnical expression of Cap43 and Mina53 proteins in neuroblastoma2007

    • Author(s)
      Fukahori, S
    • Journal Title

      J Pediatric Surgery 42

      Pages: 1831-1840

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression profile of class I histone deacetylases in human canCer tissues2007

    • Author(s)
      Nakagawa, M.
    • Journal Title

      Oncology Rep 18

      Pages: 769-774

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory stimuli from macrophages and cancer cells syneristically promote tumor growth and anioenesis2007

    • Author(s)
      Kimura, Y.
    • Journal Title

      Cancer Sciellce 98

      Pages: 2009-2018

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of HER2 and estrogen receptor alpha depends upon nuclear localization of Y-box binding protein-1 in humanbreast cancers2007

    • Author(s)
      Fujii, T.
    • Journal Title

      Cancer Res 68

      Pages: 1504-1512

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 血管新生抑制剤 : その歴史と将来2009

    • Author(s)
      桑野信彦
    • Organizer
      第7回日本臨床腫瘍学会学術集会
    • Place of Presentation
      名古屋(教育講演)
    • Year and Date
      2009-03-21
    • Related Report
      2008 Final Research Report
  • [Presentation] 血管新生を標的としたがん治療の展開2009

    • Author(s)
      桑野信彦
    • Organizer
      中国・四国広域がんプロ養成コンソーシアム
    • Place of Presentation
      徳島
    • Year and Date
      2009-02-13
    • Related Report
      2008 Final Research Report
  • [Presentation] NDRG1/Cap43のヒト膵癌における血管新生の制御2008

    • Author(s)
      細井文仁, 他
    • Organizer
      第67会日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] CBDCA+PTX投与を行なった術後再発非小細胞癌患者におけるERCC1, Class111・-Tubulinの発現と予後2008

    • Author(s)
      東公一, 他
    • Organizer
      第67会日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] がんの血管新生とリンパ管新生におけるNF-kBシグナルの役割2008

    • Author(s)
      渡公佑, 他
    • Organizer
      第67会日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肺癌における核内YB-1局在は予後不良を示しEGFRファミリーの発現と関連する2008

    • Author(s)
      樫原正樹, 他
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 乳がんにおけるYB-1によるHER2, Er・及びCXCR-4の発現制御2008

    • Author(s)
      馬崎雄二, 他
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高・中分化型胃癌における転移抑制遺伝子NDRG1/Cap43は、HER2, E-cadherin/・-catenin発現と関連を示す2008

    • Author(s)
      河原明彦, 他
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] がん治療の最前線と新しい時代2008

    • Author(s)
      桑野信彦
    • Organizer
      第11回メディカルサミット2008
    • Place of Presentation
      福岡
    • Year and Date
      2008-09-21
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] がんのレドックス応答と発症から進展を標的とした診断・創薬のイノベーション研究2008

    • Author(s)
      桑野信彦
    • Organizer
      第7回国際バイオフォーラム
    • Place of Presentation
      東京
    • Year and Date
      2008-07-02
    • Related Report
      2008 Final Research Report
  • [Presentation] がんのバイオマーカーとしてのY-ボックス結合蛋白-1(YB-1)の核内局在2008

    • Author(s)
      桑野信彦
    • Organizer
      第12回分子標的がん治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 抗癌剤の感受性・耐性の分子機序と癌最適化医療(特別講演)2007

    • Author(s)
      桑野信彦
    • Organizer
      第46回日本臨床細胞学会秋季大会
    • Place of Presentation
      宮城
    • Year and Date
      2007-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗癌剤の感受性・耐性の分子機序と癌最適化医療2007

    • Author(s)
      桑野 信彦
    • Organizer
      第46回日本臨床細胞学会秋季大会
    • Place of Presentation
      宮城
    • Year and Date
      2007-12-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] がん化学療法のあり方"-基礎医学の立場から(合同シンポジウム)2007

    • Author(s)
      桑野信彦
    • Organizer
      日本癌治療学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] y-ボックス結合蛋白1(YB-1)はヒト癌の悪性進展の重要な分子標的となるか【I】卵巣癌と乳癌における核内移行と増殖制御2007

    • Author(s)
      馬崎 雄二, 他
    • Organizer
      第11回がん分子標的治療研究会総会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] Y-ボックス結合蛋白1(YB-1)はヒト癌の悪性進展の重要な分子標的となるか【II】肺癌におけるEGFRファミリー発現とGefinib感受性2007

    • Author(s)
      樫原 正樹, 他
    • Organizer
      第11回がん分子標的治療研究会総会
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report
  • [Presentation] "がん化学療法のあり方"-基礎医学の立場から2007

    • Author(s)
      桑野 信彦
    • Organizer
      日本癌治療学会総会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation]

    • Author(s)
      桑野信彦
    • Organizer
      日本臨床腫瘍学会
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] EGFレセプターを標的とした薬剤の有効性の予測方法2009

    • Inventor(s)
      桑野信彦
    • Industrial Property Rights Holder
      国立大学法人九州大学
    • Filing Date
      2009-01-26
    • Related Report
      2008 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] EGFレセプターを標的とした薬剤の有効性の予測方法2009

    • Inventor(s)
      桑野信彦
    • Industrial Property Rights Holder
      国立大学法人九州大学
    • Filing Date
      2009-01-26
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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