Identification of a receptor for the carcinogenic factor secreted from H.pylori, and analysis of its membrane trafficking mechanism
| Project/Area Number |
19590325
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Research Institute for Clinical Oncology, Saitama Cancer Center |
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Principal Investigator |
SUGANUMA Masami Research Institute for Clinical Oncology, Saitama Cancer Center, 臨床腫瘍研究所, 主幹 (20196695)
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| Co-Investigator(Kenkyū-buntansha) |
葛原 隆 徳島文理大学, 薬学部, 教授 (00260513)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | NF-κB / ピロリ菌 / TNF-α inducing protein / TNF-α / ヌクレオリン / 発がんプロモーション / 炎症 / 胃がん / Tipαレセプター / 発がん促進 / DNA 結合 / 発がん足進 / Biacore |
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| Research Abstract |
Tumor necrosis factor-α inducing protein (Tipα) is a unique carcinogenic factor released from H.pylori. We found that nucleolin acts as a receptor for Tipα, that it shuttles Tipα from the cell surface to nuclei, resulting in TNF-α gene expression. Although nucleolin is a well-known nucleolar protein, nucleolin is also present on the cell surface of gastric cancer cells. So cells with nucleolin on the surface are thought to be a highly susceptible to Tipα for development of gastric cancer. These results indicate the significance of Tipα interaction with nucleolin as a new carcinogenic mechanism in the stomach.
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Report
(4 results)
Research Products
(68 results)
