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Suppression of invasion of cancers by blocking ephrin-B1 mediated signaling

Research Project

Project/Area Number 19590326
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionAkita University (2008)
National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East (2007)

Principal Investigator

TANAKA Masamitsu  Akita University, 医学部, 教授 (20291396)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywordsephrin / Eph / スキルス癌 / シグナル伝達 / 治療
Research Abstract

Ephrin-B1のC末を介したシグナル伝達により、Arf1の活性化依存性にメタロプロテアーゼ(MMP-8)の細胞外分泌が促進されるメカニズムが同定できた。それを踏まえ、ephrin-B1のC末部分の合成ペプチドによって上記経路が遮断されること、およびヌードマウス腹腔内に同ペプチドを投与することでスキルス胃癌細胞の腹膜播種の抑制効果が確認された。Ephrin-B1の細胞内シグナル伝達の遮断が、スキルス胃癌などの組織浸潤、播種の阻止に有効である結果が得られた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (15 results)

All 2009 2008 2007

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (6 results)

  • [Journal Article] A novel RNA-binding protein Ossa/C9orf10 regulates activity of Src kinases to protect cells from oxidative-stress induced apoptosis2009

    • Author(s)
      Tanaka M., Sasaki K., Kamata, R., Yanagihara K. and Sakai R.
    • Journal Title

      Mol Cell Biol 29

      Pages: 402-413

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel RNA binding protein Ossa/C9orf10 regulates activity of Src kinases to protect cells from oxidative-stress induced apoptosis2009

    • Author(s)
      Tanaka M., Sasaki K., Kamata, R.,Yanagihara K., and Sakai R.
    • Journal Title

      Mol Cell Biol 29

      Pages: 402-413

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CDCP1 regulates peritoneal dissemination of gastric scirrhous carcinoma2008

    • Author(s)
      Uekita T., Tanaka M., Takigahira M., Miyazawa Y., Kanai Y., Yanagihara K. Sakai R.
    • Journal Title

      American Journal of Pathology 172

      Pages: 1729-1739

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] CDCP1 regulates peritoneal dissemination of gastric scirrhous carcinoma2008

    • Author(s)
      Uekita T., Tanaka M., Takigahira M., Miyazawa Y., Kanai Y.. Yanaeihara K. Sakai R.
    • Journal Title

      American J Pathol 172

      Pages: 1729-1739

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CDCP1 regulates peritoneal dissemination of gastric scirrhous carcinoma.2008

    • Author(s)
      Uekita T., Tanaka M., Takigahira M., Miyazawa Y., Kanai Y., Yanagihara K. and Sakai R
    • Journal Title

      American Journal of Pathology (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells2007

    • Author(s)
      Tanaka M., Sasaki K., Kamata, R., and Sakai R.
    • Journal Title

      J. Cell Sci. 120

      Pages: 2179-2189

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of ephrin-B1 regulates dissemination of gastric scirrhous carcinoma2007

    • Author(s)
      Tanaka M., Kamata R., Takigahira M., Yanagihara K. and Sakai R.
    • Journal Title

      American Journal of Pathology 171

      Pages: 68-78

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of ephrin-B1 regulates dissemination of gastric scirrhous carcinoma.2007

    • Author(s)
      Tanaka M., Kamata R., Takigahira M., Yanagihara K. and Sakai R.
    • Journal Title

      American Joumal of Pathology 171

      Pages: 68-78

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The C-terminus of ephrin-B1 regulates metalloproteinase secretion and in vasion of cancer cells.2007

    • Author(s)
      Tanaka M, Sasaki K, Kamata, R. and Sakai R.
    • Journal Title

      J Cell Science 120

      Pages: 2179-2189

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Identification of tyrosine phosphorylated proteins binding to Src family kinases in gastric scirrhous carcinoma2008

    • Author(s)
      Tanaka M., Kamata R., Sasaki K., Sakai R
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] スキルス型癌の間質浸潤におけるリン酸化蛋白質の解析2008

    • Author(s)
      田中正光、鎌田礼子、堺隆一
    • Organizer
      第97回日本病理学術総会
    • Place of Presentation
      石川県立音楽堂
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 分子標的としてのephrin-B1信号伝達2007

    • Author(s)
      田中正光、鎌田礼子、堺隆一
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ
    • Year and Date
      2007-10-05
    • Related Report
      2008 Final Research Report
  • [Presentation] CDCP1はスキルス胃癌の腹膜播種の制御に関与する因子である2007

    • Author(s)
      上北尚正、田中正光、柳原五吉、堺隆一
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Ephrin-B1 as a therapeutic target of cancer invasion2007

    • Author(s)
      Tanaka M., and Sakai R.
    • Organizer
      Mechanisms and Models of cancer
    • Place of Presentation
      Salk Institute, La Jolla, USA
    • Year and Date
      2007-08-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Ephrin-B1 as a therapeutic target of cancer invasion2007

    • Author(s)
      Tanaka M., and Sakai R
    • Organizer
      Mechanisms and Models of Cancer
    • Place of Presentation
      Salk Institute,La Jolla,USA
    • Year and Date
      2007-08-10
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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