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Analysis of novel maternal effect gene, Ces5

Research Project

Project/Area Number 19590333
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human genetics
Research InstitutionOsaka University

Principal Investigator

TASHIRO Fumi  Osaka University, 医学系研究科, 助教 (40136213)

Co-Investigator(Kenkyū-buntansha) 倭 英司  大阪大学, 医学系研究科, 准教授 (20273667)
Co-Investigator(Renkei-kenkyūsha) YAMATO Eiji  大阪大学, 医学系研究科, 准教授 (20273667)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords発生・分化 / 遺伝子 / ノックアウト
Research Abstract

ES細胞の分化や未分化状態に関与する遺伝子は、生体における発生・分化過程の理解にも有用と考えられ、未分化ES細胞に特異的に発現する遺伝子を単離しCes5と名付けた。作製したノックアウトマウスの雌の不妊を認め、新規なmaternal effect遺伝子と考えられた。電子顕微鏡を用いた解析結果より、Ces5は卵の細胞質内の繊維状構造物の構築に関与し、構造体の成分あるいは構築に必須の蛋白であり、初期胚の発生に重要な役割を持つことが示唆された

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (12 results)

All 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results)

  • [Journal Article] Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia2009

    • Author(s)
      Toyoda, S., Miyazaki, T., Miyazaki, S., Yoshimura, T., Yamamoto, M., Tashiro, F., Yamato, Y. & Miyazaki, J.
    • Journal Title

      Dev. Biol 325

      Pages: 238-248

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia2009

    • Author(s)
      Toyoda, S.
    • Journal Title

      Developmental Biology 325

      Pages: 238-248

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression pattern of Cue110 : a member of the uncharacterized UPF0224 gene family preferentially expressed in germ cells2007

    • Author(s)
      Yoshimura, T., Miyazaki, T., Toyoda, S., Miyazaki, S., Tashiro, F., Yamato, E. & Miyazaki, J.
    • Journal Title

      Gene Expression Patterns 8

      Pages: 27-35

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression pattern of Cue110: a member of the uncharacterized UPF0224 gene family preferentially expressed in germ cells.2007

    • Author(s)
      Yoshimura, T.
    • Journal Title

      Gene Expression Patterns 8

      Pages: 27-35

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新規maternal effect遺伝子Ces5のノックアウトマウスの解析2008

    • Author(s)
      田代文
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸市
    • Year and Date
      2008-12-11
    • Related Report
      2008 Final Research Report
  • [Presentation] マウス精子形成・卵形成に関与するbHLH型転写因子CUE318の機能解析2008

    • Author(s)
      豊田秀一
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸市
    • Year and Date
      2008-12-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 精巣におけるレトロトランスポゾン発現抑制に関与するマウスCue110遺伝子の機能解析2008

    • Author(s)
      能村卓慈
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸市
    • Year and Date
      2008-12-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 新規maternal effect遺伝子Ces5のノックアウトマウスの解析2008

    • Author(s)
      田代 文
    • Organizer
      第31回日本分子生物学会
    • Place of Presentation
      神戸市
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウスのES細胞および卵子で特異的に発現する新規maternal effect遺伝子Ces5の解析2007

    • Author(s)
      田代文
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 精子形成・卵形成に関与するbHLH型遺伝子Cue318の機能解析2007

    • Author(s)
      豊田秀一
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 精子形成異常を示すCue110ノックアウトマウスの表現型解析2007

    • Author(s)
      能村卓慈
    • Place of Presentation
      横浜市
    • Year and Date
      2007-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスのES細胞および卵子で特異的に発現する新規maternal effect遺伝子Ces5の解析2007

    • Author(s)
      田代 文
    • Organizer
      第30回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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