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Genomic constitutions characteristic of the differentiated-type early gastric carcinomas that are prone to progress to advanced stages

Research Project

Project/Area Number 19590345
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionShiga University of Medical Science

Principal Investigator

SUGIHARA Hiroyuki  Shiga University of Medical Science, 医学部, 准教授 (30171169)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords消化器 / 胃癌 / 分化型早期胃癌 / アレイCGH / 系譜解析 / 癌進展 / p53 / β-カテニン / CGH / LOH
Research Abstract

早期および進行期の分化型胃癌25例での粘膜内病変の染色体CGHにより、大半の進行癌では、早期癌でよく見られる変化が受け継がれていないことが判明した。またうち19例に3例の早期癌を加えた22例でのアレイCGHでは、粘膜内癌および浸潤癌の粘膜部でMYC-かつTP53+が、浸潤部ではMYC+またはTP53-が特徴的であった。これらのことは、分化型早期胃癌の多くでは進行癌と系譜が異なることを示唆している。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (15 results)

All 2010 2009 2008 2007 Other

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (8 results) Book (1 results)

  • [Journal Article] A case of multiple diffuse gastric carcinoma with regional expression of mutant E-cadherin.2008

    • Author(s)
      Bamba M
    • Journal Title

      Virchows Arch 452

      Pages: 581-583

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intratumoural heterogeneity of intestinal expression reflects environmental induction and progression-related loss of induction in undifferentiated-type gastric carcinomas.2008

    • Author(s)
      Natsagdorj L
    • Journal Title

      Histopathology 53

      Pages: 685-697

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腺管腺癌に由来する未分化型胃癌の系譜解析2007

    • Author(s)
      杉原洋行
    • Journal Title

      Cytometry Research 42

      Pages: 1589-1596

    • NAID

      10019946279

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 腺管腺癌に由来する未分化型胃癌の系譜解析2007

    • Author(s)
      杉原 洋行
    • Journal Title

      Cytometry Research 17

      Pages: 19-24

    • NAID

      10019946279

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 未分化型胃癌混在早期胃癌の病理学的特徴と問題点: 分子病理学的特徴2007

    • Author(s)
      馬場 正道
    • Journal Title

      胃と腸 42

      Pages: 1589-1596

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Lineage analysis of early and advanced tubular adenocarcinomas of the stomach : continuous or discontinuous?

    • Author(s)
      Nakayama T, Ling Z, Mukaisho K, Hattori T, Sugihara H
    • Journal Title

      BMC Cancer (in press)

    • Related Report
      2008 Final Research Report
  • [Presentation] 粘膜内および進行期分化型胃癌の染色体解析2010

    • Author(s)
      仲山貴永, 杉原洋行, 凌志強, 向所賢一, 服部隆則
    • Organizer
      第82回日本胃癌学会総会
    • Place of Presentation
      新潟
    • Year and Date
      2010-03-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Immunohistochemical properties of tubular early gastric carcinomas that can precede poorly/well differentiated carcinoma2009

    • Author(s)
      Nakayama T, Sugihara H, Mukaisho K, Ling ZQ, Hattori T
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 分化型および未分化型進行胃癌に進展する早期分化型胃癌の特徴2009

    • Author(s)
      仲山貴永, 杉原洋行, 向所賢一, 凌志強, 服部隆則
    • Organizer
      第19回日本サイトメトリー学会学術集会
    • Place of Presentation
      松江
    • Year and Date
      2009-06-20
    • Related Report
      2008 Final Research Report
  • [Presentation] 未分化型胃癌に進展する分化型胃癌の特徴2009

    • Author(s)
      仲山貴永, 杉原洋行, 向所賢一, 凌志強, 服部隆則
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-01
    • Related Report
      2008 Final Research Report
  • [Presentation] 未分化型胃癌に進展しうる分化型早期胃癌の染色体解析2008

    • Author(s)
      仲山貴永, 杉原洋行, 凌志強, 吉村彰伸, 向所賢一, 服部隆則
    • Organizer
      第18回日本サイトメトリー学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 未分化型胃癌に進展しうる分化型早期胃癌の染色体解析2008

    • Author(s)
      仲山貴永
    • Organizer
      第18回日本サィトメトリー学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 胃における未分化型進行癌に進展しうる早期分化型腺癌の染色体解析-特に17番染色体を中心として-2008

    • Author(s)
      仲山貴永, 杉原洋行, Lingzhi-Qiang, 吉村彰伸, 向所賢一, 服部隆則
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Analysis of chromosome 17p in tubular early gastric carcinomas that precedes poorly differentiated advanced carcinomas2007

    • Author(s)
      Nakayama T, Suara H Ling ZQ, Yoshimura A, Mukaisho K, Hattori T
    • Organizer
      第66回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Book] 腫瘍鑑別診断アトラス胃癌 (深山正久, 大倉康男編)2009

    • Author(s)
      杉原洋行
    • Publisher
      文光堂
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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