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Genome-wide analysis of renal cell carcinoma with array-based CGH and transcriptome

Research Project

Project/Area Number 19590355
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionOita University

Principal Investigator

MATSUURA Keiko  Oita University, 医学部, 准教授 (00291542)

Co-Investigator(Kenkyū-buntansha) MORIYAMA Masatsugu  大分大学, 医学部, 教授 (90239707)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
KeywordsアレイCGH / 腎癌 / トランスクリプトーム / 遺伝子解析 / 病型分類
Research Abstract

アレイCGHを用いて腎細胞癌(CCC)の発症にかかわるゲノム異常を検索したところ、特に14番染色体長腕(14q)の欠失が、高悪性度のCCCで高頻度にみられた。さらに網羅的遺伝子発現解析(トランスクリプトーム解析)を行い、ゲノムのコピー数異常が遺伝子発現異常に影響を与えていることを見出した。14qで遺伝子発現低下を示した遺伝子のいくつかは、実際に腎癌で遺伝子の発現が減弱しており、CCCの悪性化に関わる癌関連遺伝子と考えられた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (19 results)

All 2008 2007

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (5 results)

  • [Journal Article] Genome-wide microRNA expression profiling in renal cell carcinoma : significant downregulation of miR-141 and miR-200c2008

    • Author(s)
      Nakada C., Matsuura K., Tsukamoto Y., Tanigawa M., Yoshimoto T., Narimatsu T., Nguyen LT., Hijiya N., Uchida T., Sato F., Mimata H., Seto M., Moriyama M.
    • Journal Title

      The Journal of Pathology 216

      Pages: 418-427

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer2008

    • Author(s)
      Tsukamoto Y., Uchida T., Karnan S., Noguchi T., Nguyen LT., Tanigawa M., Takeuchi I., Matsuura K., Hijiya N., Nakada C., Kishida T., Kawahara K., Ito H., Murakami K., Fujioka T., Seto M., Moriyama M.
    • Journal Title

      The Journal of Pathology 216

      Pages: 471-482

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation status of epidermal growth factor receptor is closely associated with responsiveness to gefitinib in pulmonary adenocarcinoma2008

    • Author(s)
      Hijiya N., Miyawaki M., Kawahara K., Akamine S., Tsuji K., Kadota J., Akizuki S., Uchida T., Matsuura K., Tsukamoto Y., Moriyama M.
    • Journal Title

      Human Pathology 39

      Pages: 316-323

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Arpp/Ankrd2, a member of the muscle ankyrin repeat proteins (MARPs), translocates from the I-band to the nucleus after muscle injury2008

    • Author(s)
      Tsukamoto Y., Hijiya N., Yano S., Yokoyama S., Nakada C., Uchida T., Matsuura K., Moriyama M.
    • Journal Title

      Histochemistry and Cell Biology 129

      Pages: 55-64

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genotyping of the cagA gene of Helicobacter pylori on immunohistochemistry with East Asian CagA-specific antibody2008

    • Author(s)
      Kanada R., Uchida T., Tsukamoto Y., Nguyen LT., Hijiya N., Matsuura K., Kodama M., Okimoto T., Murakami K., Fujioka T., Yanagisawa S., Moriyama M.
    • Journal Title

      Pathology International 58

      Pages: 218-225

    • NAID

      10027376254

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide microRNA expression profiling in renal cell carcinoma : significant downregulation of miR-141 and miR-200c.2008

    • Author(s)
      Nakada C, Matsuura K., Tsukamoto Y., Tanigawa M., Yoshimoto T., Narimatsu T., Nguyen LT., Hijiya N., Uchida T., Sato F., Mimata H., Seto M., Morivama M.
    • Journal Title

      The Journal of Pathology 216

      Pages: 418-427

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide analysis of DNA copy number alterations and gene expression ingastric cancer.2008

    • Author(s)
      Tsukamoto Y., Uchida T., Karnan s., Noguchi T., Nguyen LT., Tanigawa M., Takeuchi I., Matsuura K., Hijiya N., Nakada C., Kishlda T., Kawahara K., Ito H., Murakami K., Fujioka T., Seto M., Moriyama M.
    • Journal Title

      The Journal of Pathology 216

      Pages: 471-482

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation status of epidermal growth factor receptor is closely associatedwith responsiveness to gefitinib in pulmonary adenocarcinoma.2008

    • Author(s)
      Hijiya N., Miyawaki M., Kawahara K., Akamine S., Tsuji K., Kadota J., Akizuki S., Uchida T., Matsuura K., Tsukamoto Y., Moriyama M
    • Journal Title

      Human Pathology 39

      Pages: 316-323

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arpp/Ankrd2, a member of the muscle ankyrin repeat proteins(MARPs), translocates from the I-band to the nucleus after muscle injury.2008

    • Author(s)
      Tsukamoto Y., Hijiya N., Yano S., Yokoyama S., Nakada C, Uchida T., Matsuura K., Morivama M.
    • Journal Title

      Histochemistry and Cell Biology 129

      Pages: 55-64

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genotyping of the cagA gene of Helicobacter pylori on immunohistochemistry with East Asian CagA-specific antibody.2008

    • Author(s)
      Kanada R., Uchida T., Tsukamoto Y., Nguyen LT., Hijiya N., Matsuura K., Kodama M., Okimoto T., Murakami K., Fujioka T., Yanagisawa S., Morivama M.
    • Journal Title

      Pathology International 58

      Pages: 218-225

    • NAID

      10027376254

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution analysis of DNA copy number alterations and the gene expression in renal clear cell carcinoma2007

    • Author(s)
      Yoshimoto T, Matsuura K, Karnan S, Tagawa H, Nakada C, Tanigawa M, Tsukamoto Y, Uchida T, Kashima K, Akizuki S, Takeuchi I, Sato F, Mimata H, Seto M, Moriyama M.
    • Journal Title

      Journal of Pathology 213

      Pages: 392-401

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregulated expression of cardiac ankyrin-repeated protein in renal podocytes is associated with proteinuria severity in lupus nephritis2007

    • Author(s)
      Matsuura K, Uesugi N, Hijiya N, Uchida T and Moriyama M
    • Journal Title

      Human Pathology 38

      Pages: 410-419

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution analysis of DNA copy number alterations and the gene expression in renal clear cell carcinoma.2007

    • Author(s)
      Yoshimoto T, Matsuura K, Karnan S, Tagawa H, Nakada C, Tanigawa M, Tsukamoto Y, Uchida T, Kashhna K, Akizuki S, Takeuchi I, Sato F, Mimata H, Seto M, Moriyama M.
    • Journal Title

      Journal of Pathology 213

      Pages: 392-401

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulated expression of cardiac ankyrin-repeated protein in renal podocytes is associated with proteinuria severity in lupus nephritis.2007

    • Author(s)
      Matsuura K, Uesugi N, Hijiya N, Uchida T and Moriyama M
    • Journal Title

      Human Pathology 38

      Pages: 410-419

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] High-resolution analysis of DNA copy number alterations and the gene expression in renal clear cell carcinoma2008

    • Author(s)
      Taichiro Yoshimoto
    • Organizer
      American Urological Association (AUA) 2008 Annual Meeting
    • Place of Presentation
      Florida
    • Year and Date
      2008-05-18
    • Related Report
      2008 Final Research Report
  • [Presentation] アレイCGHによる腎癌転移巣における網羅的ゲノム解析2008

    • Author(s)
      成松隆弘
    • Organizer
      第96回日本泌尿器科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-26
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] High-resolution analysis of DNA copy number alterations and the geneexpression in renal clear cell carcinoma2008

    • Author(s)
      Taichiro Yoshimoto, Keiko Matsuura, Masao Seto, Takahiro Narimatsu, Fuminori Sato, Hiromitsu Mimata, Masatsugu Moriyama
    • Organizer
      American Urological Association (AUA) 2008Annual Meeting
    • Place of Presentation
      Florida
    • Related Report
      2008 Annual Research Report
  • [Presentation] High-resolution analysis of DNA copy number alterations and the gene expression in renal clear cell carcinoma2007

    • Author(s)
      Keiko Matsuura
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] High-resolution analysis of DNA copy number alterations and the gene expression in renal clear cell carcinoma2007

    • Author(s)
      Keiko Matsuura, Taichiro Yoshimoto, Sivasundaram Karnan, Hiroyuki Tagawa, Chisato Nakada, Masato Tanigawa, Yoshiyuki Tsukamoto, Tomohisa Uchida, Ichiro Takeuchi, Fuminori Sato, Hiromitsu Mimata, Masao Seto, Masatsugu Moriyama
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜市(パシフィコ横浜)
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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