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Study on genetic analyses for pathological diagnosis and therapy in glioma

Research Project

Project/Area Number 19590360
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionNara Medical University

Principal Investigator

MITSUTOSI Nakamura  Nara Medical University, 医学部, 准教授 (00305715)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsglioblastoma / glioma / heterogeneity / chemotherapy / O^6-MGMT / temozolomide / cancer stem cell
Research Abstract

組織多様性を示す神経膠腫では各組織型におけるgenotype が異なる場合があり、治療を含めた臨床病理学的な診断には、遺伝子変異の解析が必要な場合がある。特に悪性神経膠腫においては治療感受性を判定するには、組織型ごとにO6-MGMTをはじめ複数の因子を解析することによって最適の治療を選択できると考えられた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (54 results)

All 2009 2008 2007 Other

All Journal Article (30 results) (of which Peer Reviewed: 25 results) Presentation (24 results)

  • [Journal Article] A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression2009

    • Author(s)
      Shimada K, Nakamura M, Konishi N(他5名)
    • Journal Title

      Cancer Res 69

      Pages: 3157-3164

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical analysis of neuroendocrine differentiation in prostate cancer2009

    • Author(s)
      Ishida E, Nakamura M. Konishi N (他2名)
    • Journal Title

      Pathobiology 76

      Pages: 30-38

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isoflurane exerts a short-term but not a long-term preconditioning effect in neonatal rats exposed to a hypoxic-ischaemic neuronal injury2009

    • Author(s)
      Sasaoka N, Nakamura M , Konishi N (他2名)
    • Journal Title

      Acta Anaesthesiol Scand 53

      Pages: 46-54

    • Related Report
      2008 Final Research Report
  • [Journal Article] Function of JunB in transient amplifying cell senescence and progression of human prostate cancer2008

    • Author(s)
      Konishi N, Nakamura M (他5名)
    • Journal Title

      Clin Cancer Res 14(14)

      Pages: 4408-16

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostate cancer antigen-1 contributes to cell survival and invasion though discoidin receptor 1 in human prostate cancer2008

    • Author(s)
      Shimada K, Nakamura M (他4名), Konishi N
    • Journal Title

      Cancer Sci 99

      Pages: 39-45

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytologic feature by squash preparation of pineal parenchyma tumor of intermediate differentiation2008

    • Author(s)
      Shimada K, Nakamura M (他4名)
    • Journal Title

      Diagn Cytopathol 36

      Pages: 749-53

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] HRK inactivation associated with promoter methylation and LOH in prostate cancer2008

    • Author(s)
      Higuchi T, Nakamura M(他4名)
    • Journal Title

      Prostate, 68

      Pages: 105-13

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of delta-opioid agonist SNC80 on white matter injury following spinal cord ischemia in normothermic and mildly hypothermic rats2008

    • Author(s)
      Horiuchi, T, Nakamura M (他5名), Konishi N
    • Journal Title

      J Anesth 22

      Pages: 32-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] グリオーマ治療観点からの病理診断の意義2008

    • Author(s)
      中村光利, 小西登
    • Journal Title

      病理と臨床 26

      Pages: 86-7

    • Related Report
      2008 Final Research Report
  • [Journal Article] Prostate cancer antigen-1 contributes to cell survival and invasion though discoidin receptor 1 in human prostate cancer.2008

    • Author(s)
      Shimada, K., Nakamura, Konishi, N., et al
    • Journal Title

      Cancer Sci 99

      Pages: 39-45

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of delta-opioid agonist SNC80 on white matter injury following spinal cord ischemia in normothermic and mildly hypothermic rats.2008

    • Author(s)
      Horiuchi, T., Nakamura, Konishi, N., et al
    • Journal Title

      J Anesth 22

      Pages: 32-37

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Function of JunB in transient amplifying cell senescence and progression of human prostate cancer.2008

    • Author(s)
      Konishi, N. Nakamura, et al
    • Journal Title

      Clin Cancer Res 14

      Pages: 4408-4416

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytologic feature by squash preparation of pineal parenchyma tumor of intermediate differentiation.2008

    • Author(s)
      Shimada, K., Nakamura, Konishi, N., et al
    • Journal Title

      Diagn Cytopathol 36

      Pages: 749-753

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isoflurane exerts a short-term but not a long-term preconditioning effect in neonatal rats exposed to a hypoxic-ischaemic neuronalinjury.2008

    • Author(s)
      Sasaoka, N., Nakamura, Konishi, N., et al
    • Journal Title

      Acta Anaesthesiol Scand 53

      Pages: 46-54

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] グリオーマ治療観点からの病理診断の意義2008

    • Author(s)
      中村 光利, 小西 登
    • Journal Title

      病理と臨床 26

      Pages: 86-87

    • Related Report
      2007 Annual Research Report
  • [Journal Article] HRK inactivation associated with promoter methylation and LOH in prostate cancer2008

    • Author(s)
      Higuchi, T., Nakamura, M. Konishi, N., et. al.
    • Journal Title

      Prostate 68

      Pages: 105-113

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳腫瘍の病理診断における遺伝子解析の有用性2007

    • Author(s)
      中村光利, 小西登
    • Journal Title

      Neuro-Oncologyの進歩 16

      Pages: 7-11

    • NAID

      130001933527

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] c-Jun NH2 terminal kinase activation and decreased expression of mitogen-activated protein kinase phosphatase-1 play important roles in invasion and angiogenesis of urothelial carcinomas2007

    • Author(s)
      Shimada K, Nakamura M, Konishi N 他4名
    • Journal Title

      Am J Pathol 171_

      Pages: 1003-12

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] c-Jun NH2 terminal kinase activation and decreased expression of mitogen-activated protein kinase phosphatase-1 play important roles in invasion and angiogenesis of urothelial carcinomas2007

    • Author(s)
      Shin K, Nakamura M (他3名), Konishi N
    • Journal Title

      Neurol Res 29

      Pages: 727-33

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A rare case of malignant glioma suspected to have arisen from a cavernous sinus2007

    • Author(s)
      Taomoto, K, Nakamura M (他8名)
    • Journal Title

      Brain Tumor Pathol 24

      Pages: 75-80

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of delta-opioid receptor stimulation and inhibition on hippocampal survival in a rat model of forebrain ischaemia2007

    • Author(s)
      Iwata M, Nakamura M (他3名), Konishi N
    • Journal Title

      Br J Anaesth 99

      Pages: 538-46

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular pathogenesis of pediatric astrocytic tumors2007

    • Author(s)
      Nakamura, M, Shimada, K, Konishi, N., et. al.
    • Journal Title

      Neuro-Oncol 9

      Pages: 113-123

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳腫瘍の病理診断における遺伝子解析の有用性2007

    • Author(s)
      中村 光利, 小西 登, 他
    • Journal Title

      Neruo-Oncologyの進歩 16

      Pages: 7-11

    • NAID

      130001933527

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of angiogenic growth factor in the rat DAVFmodel2007

    • Author(s)
      Shin, Y., Nakamura, M., Konishi, N., Sakaki, T., et. al.
    • Journal Title

      Neurol Res 29

      Pages: 727-733

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA hypermethylation status of multiple genes in papillarythyroid carcinomas2007

    • Author(s)
      Ishida, E., Nakamura, M., Konishi, N., et. al.
    • Journal Title

      Pathobiology 74

      Pages: 344-352

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostate cancer antigen-1 contributes to cell survival and invasionthough discoidin receptor l in human prostate cance2007

    • Author(s)
      Shimada, K., Nakamura, M., Konishi, N., et. al.
    • Journal Title

      Cancer Sci 99

      Pages: 39-45

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] c-Jun NH2 terminal kinase activation and decreased expression of mitogen-activated protein kinase phosphatase-1 play important roles in invasion and angiogenesis of urothelial carcinomas2007

    • Author(s)
      Shimada, K., Nakamura, M., Konishi, N, et. al.
    • Journal Title

      Am J Pathol 171

      Pages: 1003-1012

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Co-transplantation of mouse embryonic stem cells and bone marrow stromal cells following spinal cord injury suppresses tumor development

    • Author(s)
      Matsuda R, Nakamura M (他12名)
    • Journal Title

      Cell Transplant in press

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of HRK gene in human cancer

    • Author(s)
      Nakamura M, Shimada K, Konishi N
    • Journal Title

      Oncogene in press

    • Related Report
      2008 Final Research Report
  • [Journal Article] Genotype 解析からみたグリオーマの診断

    • Author(s)
      中村光利, 小西登
    • Journal Title

      BRAIN and NERVE,総説 印刷中

    • Related Report
      2008 Final Research Report
  • [Presentation] 前立腺癌治療後の上皮細胞および間質細胞における遺伝子変異の検討2009

    • Author(s)
      中村光利, 島田啓司, 小西登 他1名
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 組織多様性を示す脳神経膠腫におけるgenotype解析の有用性2008

    • Author(s)
      中村光利, 小西登 他3名
    • Organizer
      第28回日本脳腫瘍学会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-09
    • Related Report
      2008 Final Research Report
  • [Presentation] 組織多様性を示す悪性神経膠腫におけるTMZ感受性因子としてのO6-MGMT 遺伝子の検索2008

    • Author(s)
      中村光利, 小西登 他3名
    • Organizer
      第28回日本脳腫瘍学会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-09
    • Related Report
      2008 Final Research Report
  • [Presentation] 組織多様性を示す悪性神経膠腫におけるtemozolomide 感受性因子の検索2008

    • Author(s)
      中村光利, 小西登 他3名
    • Organizer
      第28回日本脳腫瘍学会
    • Place of Presentation
      愛媛
    • Year and Date
      2008-11-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 組織多様性を示す悪性神経膠腫におけるtemozolomide感受性因子の検索2008

    • Author(s)
      中村光利, 小西 登, 他
    • Organizer
      第28回日本脳腫瘍学会
    • Place of Presentation
      愛媛
    • Year and Date
      2008-11-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] O^6-MGMT status as a marker for response to temozolomide in malignant gliomas with histological heterogeneity2008

    • Author(s)
      中村光利, 島田啓司, 石田英和, 小西登
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Human ABH-8 is a new molecule for the development of bladder cancer2008

    • Author(s)
      島田啓司, 中村光利, 小西登 他4名
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Expression of human ABH families in non-small cell lung carcinoma2008

    • Author(s)
      田崎正人, 中村光利, 小西登 他3名
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] DNA microarray analysis of multicentric prostate cancer based on the computer-assisted three-dimensional model2008

    • Author(s)
      石田英和, 中村光利, 小西登 他2名
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 組織多様性を示す悪性神経膠腫における TMZ 感受性因子としてのO6-MGMT 遺伝子の検索2008

    • Author(s)
      中村光利, 小西登 他4名
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 前立腺progenitor cellの生物学的特性と病理組織学的意義について2008

    • Author(s)
      島田啓司, 中村光利, 小西登 他2名
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 組織多様性を示す glioblastoma における genotype 解析の有用性2008

    • Author(s)
      田崎正人, 中村光利, 小西登 他3名
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 組織多様性を示す悪性神経膠腫におけるTMZ感受性因子としてのO^6-MGMT遺伝子の検索2008

    • Author(s)
      中村光利, 小西 登, 他
    • Organizer
      第97回日本病理会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 組織多様性を示すglioblastomaにおけるgenotype解析の有用性2008

    • Author(s)
      田崎正人, 中村光利, 小西 登, 他
    • Organizer
      第97回日本病理会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 前立腺progenitor cellの生物学的特性と病理組織学的意義について2008

    • Author(s)
      島田啓司, 中村光利, 小西 登, 他
    • Organizer
      第97回日本病理会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 組織多様性を示す脳神経膠腫におけるgenotype解析の有用性2007

    • Author(s)
      中村 光利, 島田 啓司, 石田 英和, 樋口 智紀, 小西 登
    • Organizer
      第25回日本脳腫瘍学会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] 組織多様性を示す悪性神経膠腫におけるTMZ感受性因子としてのO^6-MGMT遺伝子の検索2007

    • Author(s)
      中村 光利, 島田 啓司, 石田 英和, 樋口 智紀, 小西 登
    • Organizer
      第25回日本脳腫瘍学会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] 組織多様性を示す神経膠腫におけるテモゾロミド感受性因子としてのO6-MGMT 遺伝子メチル化検索2007

    • Author(s)
      中村光利, 小西登 他3名
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 組織多様性を示す脳神経膠腫におけるgenotype 解析2007

    • Author(s)
      樋口智紀, 中村光利, 小西登 他2名
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 組織多様性を示す脳神経膠腫におけるgenotype解析2007

    • Author(s)
      樋口 智紀, 中村 光利, 島田 啓司, 石田 英和, 小西 登
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 組織多様性を示す神経膠腫におけるテモゾロミド感受性因子としてのO^6-MGMT遺伝子メチル化検索2007

    • Author(s)
      中村 光利, 島田 啓司, 石田 英和, 樋口 智紀, 小西 登
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 前立腺癌Gleason gradeにおける分子マーカーの検討2007

    • Author(s)
      中村 光利, 島田 啓司, 石田 英和, 樋口 智紀, 小西 登
    • Organizer
      第18回前立腺がんワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2007-09-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 組織多様性を示す脳神経膠腫におけるgenotype 解析の有用性2007

    • Author(s)
      樋口智紀, 中村光利 (2番目), 小西登 他3名.
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Oligodendrogliomaにおける病理組織学的診断と遺伝子解析の有用性2007

    • Author(s)
      中村光利, 小西登 他4名
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-15
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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