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Roles of the Hedgehog signaling in invasion and metastasis of pancreatic cancer

Research Project

Project/Area Number 19590371
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionAichi Medical University

Principal Investigator

KASAI Kenji  Aichi Medical University, 医学部, 准教授 (70242857)

Co-Investigator(Kenkyū-buntansha) 池田 洋  愛知医科大学, 医学部, 教授 (00131219)
稲熊 真悟  愛知医科大学, 医学部, 助教 (80410786)
Co-Investigator(Renkei-kenkyūsha) IKEDA Hiroshi  愛知医科大学, 医学部, 教授 (00131219)
INAGUMA Shingo  愛知医科大学, 医学部, 助教 (80410786)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords分子病理 / 膵臓癌 / シグナル伝達 / ヘッジホッグ / 浸潤 / 転移 / 病理学 / 癌
Research Abstract

ヘッジホッグシグナル系転写因子GLI1は、新たにGLI1標的遺伝子として同定した粘液基質MUC5ACを介して膵臓癌細胞の浸潤・運動能を亢進させることを明らかにした。また癌細胞でのGLI1機能活性化には、細胞質蛋白SCL/TAL1 Interrupting Locus(SIL)がGLI1制御因子Suppressor-of-Fused(SUFU)と結合しその機能を阻害することが必要であることも解明した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (14 results)

All 2008 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (5 results) Remarks (3 results)

  • [Journal Article] SCL/TAL1 Interrupting Locus derepresses GLI1 from the negative control of Suppressor-of-Fused in pancreatic cancer cell2008

    • Author(s)
      Kenji Kasai, Shingo Inaguma, Akiko Yoneyama, Kazuhiro Yoshikawa, Hiroshi Ikeda
    • Journal Title

      Cancer Research 66

      Pages: 7723-7729

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Versican and Fibrillin-1 form a major Hyaluronan-binding complex in the ciliary body2008

    • Author(s)
      Akiko Ohno-Jinno, Zenzo Isogai, Masahiko Yoneda, Kenji Kasai, Osamu Miyaishi, Yoko Inoue, Takuya Kataoka, Jing-Song Zhao, Huili Li, Masayuki Takeyama, Douglas R. Keene, Lynn Y. Sakai, Koji Kimata, Masayoshi Iwaki, Masahiro Zako
    • Journal Title

      Investigative Ophthalmology & Visual Science 49

      Pages: 2870-2877

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Paracrine factors of vascular endothelial cells facilitate cardiomyocyte differentiation of mouse embryonic stem cells2008

    • Author(s)
      Miwako Kado, Jong-Kook Lee, Kyoko Hidaka, Keiko Miwa, Toyoaki Murohara, Kenji Kasai, Shinsuke Saga, Takayuki Morisaki, Yuichi Ueda, Itsuo Koodama
    • Journal Title

      Biochemical and Biophysical Research Communications 377

      Pages: 413-418

    • NAID

      120000976725

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] SCL/TAL1 Interrupting Locus derepresses GLI1 from the negative control of Suppressor-of-Fused in pancreatic cancer cell2008

    • Author(s)
      Kenji Kasai
    • Journal Title

      Cancer Res 68

      Pages: 7723-7729

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paracrine factors of vascular endothelial cells facilitate cardiomyocyte differentiation of mouse embryonic stem cells.2008

    • Author(s)
      Miwako Kado
    • Journal Title

      Biochem Biophys Res Commun 377

      Pages: 413-418

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Versican and Fibrillin-1 form a major Hyaluronan-binding complex in the ciliary body2008

    • Author(s)
      Akiko ohno-Jinno
    • Journal Title

      Invest Opthalmol Vis Sci 49

      Pages: 2870-2877

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] SILによるGLI1のSUFU依存性制御からの離脱機構2008

    • Author(s)
      笠井謙次、稲熊真悟、池田洋
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] がん細胞において転写因子GLI1はbHLH型転写抑制因子DEC2、HES1の発現を直接誘導する2008

    • Author(s)
      稲熊真悟、笠井謙次、池田洋
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 膵臓癌におけるHedgehogシグナル系転写因子GLI1のSUFU依存性制御からの離脱機構2008

    • Author(s)
      笠井謙次、稲熊真悟、米山亜紀子、池田洋
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 膵前癌病変におけるShh-GLI1標的遺伝子MUC5ACの発現解析2008

    • Author(s)
      稲熊真悟、笠井謙次、米山亜紀子、池田洋
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 膵前癌病変におけるShh-GLT1標的遺伝子MUC5ACの発現解析2008

    • Author(s)
      稲熊真悟
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Remarks] 中日新聞「研究室発 : がん細胞の因子解明へ」(2008年5月27日朝刊)(笠井謙次紹介記事)

    • Related Report
      2008 Final Research Report
  • [Remarks] 中日新聞「難治性癌治療に期待、細胞増殖の仕組み解明、愛知医大グループ」(2008年10月28日夕刊)(笠井謙次研究成果報道)

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.aichi-med-u.ac.jp/univ/medic/lecture2/10.html

    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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