Association studies between atherosclerosis and genetic polymorphisms of inflammatory cytokines, using large numbers of autopsy cases
| Project/Area Number |
19590377
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Metropolitan Institute of Gerontology |
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Principal Investigator |
SAWABE Motoji Tokyo Metropolitan Institute of Gerontology, 東京都老人総合研究所, 研究員 (30196331)
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| Co-Investigator(Kenkyū-buntansha) |
MURAMATSU Masaaki 東京医科歯科大学, 難治疾患研究所, 教授 (50230008)
TANAKA Noriko ハーバード大学, 大学院・生物統計, 客員研究員 (10376460)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Shinobu 東京医科歯科大学, 難治疾患研究所, 助教 (20415508)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 循環器・高血圧 / ゲノム / 病理学 / 免疫学 / 老化 |
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| Research Abstract |
本研究の目的は遺伝子多型解析という最新の手法を用いて、心筋梗塞、脳血管障害などの基礎病態である動脈硬化症の発生に関係する遺伝子を同定する事である。対象症例はセンターで行われた約2,000例の連続病理解剖症例であり、冠状動脈、脳動脈などの全身10動脈の動脈硬化度と各種遺伝子多型の関連を解析した。その結果、炎症性サイトカイン、葉酸代謝に関係する酵素、リポタンパクの遺伝子が動脈硬化症に関係していることを見つけた。
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Report
(3 results)
Research Products
(58 results)
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[Journal Article] Megakaryoblastic leukemia factor-1 gene in the susceptibility to coronary artery disease2009
Author(s)
Hinohara K, Nakajima T, Yasunami M, Houda S, Sasaoka T, Yamamoto K, Lee BS, Shibata H, Takahashi YT, Takahashi M, Arimura T, Sato A, Naruse T, Ban J, Inoko H, Yamada Y, Sawabe M, Park JE, Izumi T, Kimura A
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Journal Title
Human Genetics in press
Pages: 0-0
Related Report
Peer Reviewed
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[Journal Article] Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study.2009
Author(s)
Yamada Y, Fuku N, Tanaka M, Aoyagi Y, Sawabe M, Metoki N, Yoshida H, Satoh K, Kato K, Watanabe S, Nozawa Y, Hasegawa A, Kojima T
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Journal Title
Atherosclerosis In press
Pages: 0-0
Related Report
Peer Reviewed
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[Journal Article] Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations2008
Author(s)
Hinohara K, Nakajima T, Takahashi M, Hohda S, asaoka T, Nakahara K, Chida K, Sawabe M, Arimura T, Sato A, Lee BS, Ban JM, Yasunami M, ParkJE, Izumi T, Kimura A
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Journal Title
J Hum Genet 53
Pages: 357-359
NAID
Related Report
Peer Reviewed
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[Journal Article] Polymorphisms in pro- and anti-Inflammatory cytokine genes and susceptibility to atherosclerosis : a pathological study of 1503 consecutive autopsy cases.2007
Author(s)
Oda K, Tanaka N Song Y, Zhang L, Kuchiba A, Hosoi T,Shirasawa T, , Arai T, Araki J, Muramatsu M, Sawabe M
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Journal Title
Hum Mol Genet 16
Pages: 592-599
Related Report
Peer Reviewed
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[Journal Article] Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy.2007
Author(s)
Nakano N, Hori H, Abe M, Shibata H, Arimura T, Sasaoka T, Sawabe M, Chida K, Arai T, Nakahara K, Kubo T, Sugimoto K, Katsuya T, Ogihara T, Doi Y, Izumi T, Kimura A
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Journal Title
Am J Physiol Heart Circ 293
Related Report
Peer Reviewed
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[Journal Article] Lack of association between LTA and LGALS2 polymorphismsand myocardial infarction in Japanese and Korean Populations.2007
Author(s)
Kimura A, Takahashi M, Choi BY, Bae SW, Hohta S, Sasaoka T, Nakahara KI, CHida K, Sawabe M, Yasunami M, Naruse T, Izumi T, Park JE
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Journal Title
Tissue Antigens 69
Pages: 265-269
Related Report
Peer Reviewed
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