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Identification of cytogenesis of pancreatic cancer in Ras transgenic rats

Research Project

Project/Area Number 19590401
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionNagoya City University

Principal Investigator

FUKAMACHI Katsumi  Nagoya City University, 大学院・医学研究科, 助教 (90381798)

Co-Investigator(Kenkyū-buntansha) TSUDA Hiroyuki  名古屋市立大学, 大学院・医学研究科, 特任教授 (30094387)
ALEXANDER David  名古屋市立大学, 大学院・医学研究科, 研究員 (00335267)
津田 洋幸  名古屋市立大学, 大学院・医学研究科, 教授 (10163809)
ALEXANDER David  名古屋市立大学, 大学院・医学研究科, 客員教授 (90381805)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords腫瘍 / 膵管がん / Ras / トランスジェニックラット / ras / 膵がん
Research Abstract

Pancreatic ductal adenocarcinoma (PDA) is one of the most debilitating malignancies in humans. A thorough understanding of the cytogenesis of this disease will aid in establishing successful treatments. We have developed an animal model which uses adult ras^<G12V> transgenic rats in which oncogene expression is regulated by the Cre/loxP system. We showed that the origin of PDA is duct, intercalated duct, and centroacinar cells, but not acinar cells.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (16 results)

All 2010 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats.2010

    • Author(s)
      Tanaka, H., Fukamachi, K., Futakuchi, M., Alexander, D.B., Long, N., Tamamushi, S., Minami, K., Seino, S., Ohara, H., Joh, T., Tsuda, H.
    • Journal Title

      Cancer Sci 101

      Pages: 341-346

    • NAID

      10026587596

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats2010

    • Author(s)
      Tanaka, H., et al
    • Journal Title

      Cancer Sci 101

      Pages: 341-346

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas.2009

    • Author(s)
      Fukamachi, K., Tanaka, H., Hagiwara, Y., Ohara, H., Joh, T., Iigo, M., Alexander, D.B., Xu, J., Long, N., Takigahira, M., Yanagihara, K., Hino, O., Saito, I., Tsuda, H.
    • Journal Title

      Biochem Biophys Res Commun 390

      Pages: 636-641

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas2009

    • Author(s)
      Fukamachi, K., et al
    • Journal Title

      Biochem Biophys Res Commun 390

      Pages: 636-641

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purple corn color suppresses Ras protein level and inhibits 7, 12-dimethylbenz[a]anthracene-indu ced mammary carcinogenesis in the rat.2008

    • Author(s)
      Fukamachi, K., Imada, T., Ohshima, Y., Xu, J., Tsuda, H.
    • Journal Title

      Cancer Sci 99

      Pages: 1841-1846

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Purple corn color suppresses Ras protein level and inhibits 7, 12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in the rat2008

    • Author(s)
      Fukamachi, K., et al.
    • Journal Title

      Cancer Sci 99

      Pages: 1841-1846

    • NAID

      10024011232

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats.2007

    • Author(s)
      Tsuda, H., Iigo, M., Takasuka, N., Ueda, S., Ohshima, Y., Fukamachi, K., Shirai, T., Hirano, S., Matsuda, E., Wakabayashi, K.
    • Journal Title

      Food Chem Toxicol 45

      Pages: 1013-1019

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible application of human c-Ha-ras proto-oncogene transgenic rats in a medium-term bioassay model for carcinogens.2007

    • Author(s)
      Ohnishi, T., Fukamachi, K., Ohshima, Y., Jiegou, X., Ueda, S., Iigo, M., Takasuka, N., Naito, A., Fujita, K., Matsuoka, Y., Izumi, K., Tsuda, H.
    • Journal Title

      Toxicol Pathol 35

      Pages: 436-443

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible Application of Human c-Ha-ras Proto-Oncogene Transgenic Rats in a Medium-Term Bioassay Model for Carcinogens2007

    • Author(s)
      Ohnishi T, et. al.
    • Journal Title

      Toxicol Pathol 35

      Pages: 436-443

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats2007

    • Author(s)
      Tsuda, H, et. al.
    • Journal Title

      Food Chem Toxicol 45

      Pages: 1013-1019

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Possible identification of cytogenesis of pancreas cancer and lung cancer in the rat2009

    • Author(s)
      Hajime Tanaka, Yutaka Ohshima, Katsumi Fukamachi, David Alexander, Mitsuru Futakuchi, Takashi Joh, Hiroyuki Tsuda
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Possible identification of cytogenesis of pancreas cancer and lung cancer in the rat2009

    • Author(s)
      田中創始, 他
    • Organizer
      68回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Adult pancreatic acinar cells are refractory to transformation by Ras oncogene2008

    • Author(s)
      Hajime Tanaka, Katsumi Fukamachi, David Alexander, Mitsuru Futakuchi, Takashi Joh, Hiroyuki Tsuda
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Adult pancreatic acinar cells are refractory o transformation by Ras oncogene2008

    • Author(s)
      Tanaka H., et al.
    • Organizer
      第67回 日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] ヒト変異型K-ras(K-rasV12)遺伝子をコンディショナルに発現するトランスジェニック非ヒト哺乳動物及びその用途2007

    • Inventor(s)
      津田洋幸, 深町勝巳, デイビッド・ビー・アレキサンダー
    • Industrial Property Rights Holder
      名古屋市立大学
    • Industrial Property Number
      2007-243313
    • Filing Date
      2007-09-20
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] ヒト変異型Kras遺伝子をコンディショナルに発現するトランスジェニック非ヒト哺乳動物及びその用途2007

    • Inventor(s)
      津田洋幸、深町勝巳、Alexander David
    • Industrial Property Rights Holder
      名古屋市立大学
    • Filing Date
      2007-09-20
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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