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Analysis of development and cancer in microRNA transgenic mice

Research Project

Project/Area Number 19590408
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionChubu University

Principal Investigator

IWAMOTO Takashi  Chubu University, 生命健康科学部, 教授 (60223426)

Co-Investigator(Kenkyū-buntansha) KATO Masashi  中部大学, 生命健康科学部, 教授 (10281073)
ICHIHARA Masatoshi  中部大学, 生命健康科学部, 教授 (00314013)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords疾患動物モデル / マイクロRNA / 大腸癌 / microRNA / トランスジェニックマウス / 発生 / 発癌
Research Abstract

In the present study, we analyze the effect of microRNAs, recently discovered small non-coding RNAs, on the development and pathogenesis of cancer using their transgenic mice. We show that the tumor development of the small intestines of APC^<min> mice, which are model mice of familial adenomatous polyposis, is inhibited when crossed to miR-143 transgenic mice. We also demonstrate that proto-oncogene c-myc is downregulated in transgenic tumors.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (17 results)

All 2010 2009 2008 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (7 results) Remarks (2 results)

  • [Journal Article] Modulation of microRKA processing by p53.2009

    • Author(s)
      Suzuki H I, Yamagata K, Sugimoto K, Iwamoto T, Kato S, Miyazono K.
    • Journal Title

      Nature 460

      Pages: 529-533

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A role for AP-1 in matrix metalloproteinase production and invadopodia formation of v-Crk-transformed cells.2009

    • Author(s)
      Hasegawa H, Senga T, Ito S, Iwamoto T, Hamaguchi M.
    • Journal Title

      Exp Cell Res. 315

      Pages: 1384-1392

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A role for AP-1 in matrix metalloproteinase production and invadopodia formation of v-Crk-transformed cells2009

    • Author(s)
      Hitoki Hasegawa
    • Journal Title

      Exp Cell Res. 315

      Pages: 1384-1392

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of microRNA processing by p532009

    • Author(s)
      Hiroshi Suzuki
    • Journal Title

      Nature 460

      Pages: 529-533

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Na^+ -independent Mg^<2+> transport sensitive to 2-aminoethoxydiphenylborate (2-APB) in vascular smooth muscle eells : involvement of TRPM-like channels2009

    • Author(s)
      Yukihisa Hamaguchi
    • Journal Title

      Journal of Cellular and Molecular Medicine 12

      Pages: 962-974

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role for AP-1 in matrix metalloproteinase production and invadopodia formation of v-Crk-transformed cells.2009

    • Author(s)
      Hitoki Hasegawa
    • Journal Title

      Exp Cell Res. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of cells to monitor Microprocessor through fusion genes of microRNA and GFP2008

    • Author(s)
      Tsutsui M, Hasegawa H, Adachi K, Miyata M, Huang P, Ishiguro N, Hamaguchi M, Iwamoto T .
    • Journal Title

      Biochem BiophysRes CoRun 372

      Pages: 856-861

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of cells to monitor Microprocessor through fusion genes of microRNA and GFP.2008

    • Author(s)
      Motomu Tsutsui
    • Journal Title

      Biochemical and Biophysical Research Communications. 372

      Pages: 856-861

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 腸管上皮細胞におけるRNA結合分子Lin28の機能解析2010

    • Author(s)
      大内靖夫、朝枝祐太、岩本隆司
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2010-12-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Dynamics of microRNA biogenesis crosstalk between p53 network and microRNA processing pathway2010

    • Author(s)
      Suzuki H I, Yamagata K, Sugimoto K, 岩本隆司, Kato S, Miyazono K.
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2010-12-07
    • Related Report
      2009 Final Research Report
  • [Presentation] Zebrafishを用いたRNA結合タンパク質Lin28の機能解析2010

    • Author(s)
      山本純矢、大内靖夫、岩本隆司
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2010-12-07
    • Related Report
      2009 Final Research Report
  • [Presentation] 家族性大腸腺腫症モデルマウスにおけるmiR-143の発がん抑制機能解析2010

    • Author(s)
      Yuka Shimizu,Hitoki Hasegawa,大内靖夫, 岩本隆司
    • Organizer
      第2回日本RNAi研究会
    • Place of Presentation
      グランドプリンスホテル広島(広島市)
    • Year and Date
      2010-08-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Altered brain microRNA biogenesis affects neural stem cell proliferation in mouse hippocampal dentate gyrus.2010

    • Author(s)
      Yasuo Ouchi , Yuko Shimizu , Mai Mizuno , 岩本隆司
    • Organizer
      第8回幹細胞シンポジウム2010
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県)
    • Year and Date
      2010-05-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Establishment ofcells to monitor Microprocessor through fusion genes of microRNA and GFP2008

    • Author(s)
      Hitoki Hasegawa, 岩本隆司
    • Organizer
      BMB2008
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2008-12-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Establishment of cells to monitor Microprocessor through fusion genes of microRNA and GFP.2008

    • Author(s)
      Hitoki Hasegawa
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Remarks] 岩本研究室

    • URL

      http://www015,upp.so-net.ne.jp/chubuanimal/publication.html

    • Related Report
      2009 Final Research Report
  • [Remarks] 中部大学ヘルスサイエンスヒルズ

    • URL

      http://www.isc.chubu.ac.jp/hsh/topics.html

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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