• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification and purification of sympathetic nerve neural crest stem cells and neuroblastoma cancer stem cells

Research Project

Project/Area Number 19590409
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionAichi Medical University

Principal Investigator

KUROKAWA Kei  Aichi Medical University, 医学部, 講師 (90399030)

Co-Investigator(Kenkyū-buntansha) IWASHITA Toshihide  愛知医科大学, 医学部, 准教授 (00283432)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords腫瘍 / 癌幹細胞 / 神経芽細胞腫 / 交感神経神経堤幹細胞
Research Abstract

ラット新生児副腎髄質より神経堤幹細胞の分離を試み、p75陽性分画に神経細胞とシュワン細胞の両方向性分化能を示すコロニー形成を確認した。p75発現を認める神経芽腫細胞株で、p75陽性分画が分化階層の上位にあることを細胞培養レベルで確認した。神経芽腫細胞株を用いたスクリーニングで、神経芽腫cancer stem cellや交感神経系神経堤幹細胞の細胞表面マーカー候補となりうる分子についてのデータを得た。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (11 results)

All 2009 2008 2007 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (4 results)

  • [Journal Article] Pleomorphic carcinoma of the breast with osteoclastic giant cells2009

    • Author(s)
      Kurokawa K, Mouri Y, Asano A, Kamei K, Iwata Y, Isogai M, Saga S, Ichihara S.
    • Journal Title

      Pathol Int 59

      Pages: 91-97

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo.2009

    • Author(s)
      He S, Iwashita T, Buchstaller J, Molofsky AV, Thomas D, Morrison SJ.
    • Journal Title

      Dev Biol 328

      Pages: 257-272

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Galanin receptor subtype 2 suppresses cell proliferation and induces apoptosis in p53 mutant head and neck cancer cells2009

    • Author(s)
      Kanazawa T, Kommareddi PK, Iwashita T, Kumar B, Misawa K, Misawa Y, Jang I, Nair TS, Iino Y, Carey TE.
    • Journal Title

      Clin Cancer Res 15

      Pages: 2222-2230

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of glial cell line-derived neurotrophic factor and neurturin in a case of colon adenocarcinoma associated with diffuse ganglioneuromatosis2009

    • Author(s)
      Qiao S, Iwashita T, Ichihara M, Murakumo Y, Yamaguchi A, Isogai M, Sakata K, Takahashi M.
    • Journal Title

      Clin Neuropathol 28

      Pages: 105-112

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pleomorphic carcinoma with osteoclastic giant cells of the breast2009

    • Author(s)
      Kurokawa K, et al.
    • Journal Title

      Pathology International 59

      Pages: 91-97

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Galanin and Galanin Receptor Type 1 Suppress Proliferation in Squamous Carcinoma Cells : Activation of the Extracellular Signal Regulated Kinase Pathway and Induction of Cyclin-dependent Kinase Inhibitors2007

    • Author(s)
      Kanazawa T, Iwashita T, Kommareddi P, Nair T, Misawa K, Misawa Y, Ueda Y, Tono T, Carey TE.
    • Journal Title

      Oncogene 26

      Pages: 5762-5771

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells

    • Author(s)
      Kurotsuchi A, Murakumo Y, Jijiwa M, Kurokawa K, Itoh Y, Kodama Y, Kato T, Enomoto A, Asai N, Terasaki H, Takahashi M.
    • Journal Title

      Cancer Sci (in press)

    • NAID

      10026592015

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Ratグリオーマ組織内に存在する bipotent な分化能を有する細胞の同定2009

    • Author(s)
      黒川景, 喬善楼, 川井久美, 佐賀信介, 岩下寿秀
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-01
    • Related Report
      2008 Final Research Report
  • [Presentation] オリゴデンドロサイトの発生制御におけるBAX/BAKの役割の解析2009

    • Author(s)
      川井久美, 伊藤高行, 黒川景, 岩下寿秀, 佐賀信介
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-01
    • Related Report
      2008 Final Research Report
  • [Presentation] ラットグリオーマ組織内におけるSP (side-population) 細胞の局在2008

    • Author(s)
      黒川景, 喬善楼, 佐賀信介, 岩下寿秀
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] ラットグリオーマ組織内におけるSP(side-population)細胞の局在2008

    • Author(s)
      黒川景、喬善楼、佐賀信介、岩下寿秀
    • Organizer
      第97回 日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi