A study of secondary resistance mechanism for molecular target drugs in gastrointestinal stromal tumors
| Project/Area Number |
19590410
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
HIROTA Seiichi Hyogo College of Medicine, 医学部, 教授 (50218856)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 腫瘍 / c-kit遺伝子 / 機能獲得性突然変異 / 分子標的治療 / イマチニブ / 二次耐性 / 付加変異 / exon 13 / exon 17 / exon13 / exon17 |
|---|
| Research Abstract |
We first reported that an imatinib-secondary resistant lesion had secondary c-kit gene mutation in addition to primary c-kit gene mutation. Through analysis of many imatinib-secondary resistant lesions, 70 to 80% of them were proved to have secondary c-kit gene mutations in addition to primary c-kit gene mutations. Most of the secondary c-kit gene mutations were present at exon 13 or exon 17.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Establishment of a lymph node metastasis model from subcutaneous tumors of gastrointestinal stromal tumor model cells2009
Author(s)
S akurama K, Naomoto Y, Ohara T, Watanabe N, Takaoka M, Nagatsuka H, Tomono Y, Tanida T, Noma K, Tanabe S, Fujiwara Y, Motoki T, Shirakawa Y, Yamatsuji T, Hirota S, Taguchi T, Tanaka N
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Journal Title
Oncol Rep 21
Pages: 407-411
Related Report
Peer Reviewed
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[Journal Article] Inhibition of focal adhesion kinase as a potential therapeutic strategy for Imatinib-resistant gastrointestinal stromal tumor2009
Author(s)
S akurama K, Noma K, Takaoka M, Tomono Y, Watanabe N, Hatakeyama S, Ohmori O, Hirota S, Motoki T, Shirakawa Y, Yamatsuji T, Haisa M, Matsuoka J, Tanaka N, Naomoto Y
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Journal Title
Mol Cancer Ther 8
Pages: 127-134
Related Report
Peer Reviewed
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[Journal Article] Involvement of focal adhesion kinase in the progression and prognosis of gastrointestinal stromal tumors2009
Author(s)
K amo N, Naomoto Y, Shirakawa Y, Yamatsuji T, Hirota S, Fujiwaraa Y, Noma K, Sakurama K, Takaoka M, Nagatsuka H, Gunduz M, Matsuoka J, Tanaka N
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Journal Title
Human Pathol 40
Pages: 1643-1649
Related Report
Peer Reviewed
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[Journal Article] In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice2009
Author(s)
I shikawa T, Nakai N, Liu N-N, Shiba K, Isozaki K, Matsuda I, Ito K, Fujimoto J, Hatakeyama K, Kanda T, Hirota S
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Journal Title
Lab Invest 89
Pages: 1161-1168
Related Report
Peer Reviewed
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[Journal Article] Abberant expression of glycosylation in juvenile gastrointestinal stromal tumors2008
Author(s)
T akahashi T, Naka T, Fujimoto M, Serada S, Horino J, Terabe F, Hirota S, Miyoshi E, Hirai T, Nakajima K, Nishitani A, Souma Y, Sawa Y, Nishida T
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Journal Title
Proteomics Clin Appl 2
Pages: 1246-1254
Related Report
Peer Reviewed
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[Journal Article] Characterization of tyrosine kinase I domain c-kit gene mutation Asn655Lys newly found in primary jejunal gastrointestinal stromal tumor2007
Author(s)
K inoshita K, Hirota S, Isozaki K, Nishitani A, Tsutsui S, Watabe K, Tamura S, Ishikawa T, Kanda T, Nishida T, Hayashi N
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Journal Title
Am J Gastroenterol 102
Pages: 1134-1136
Related Report
Peer Reviewed
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[Journal Article] A mouse model of human multiple GIST family with KIT-Asp820Tyr mutation generated by knock-in strategy2007
Author(s)
N akai N, Ishikawa T, Nishitani A, Liu N-N, Shincho M, Hao H, Isozaki K, Kanda T, Nishida T, Fujimoto J, Hirota S
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Journal Title
J Pathol 214
Pages: 302-311
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Peer Reviewed
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[Journal Article] Pleomorphic phenotypes of gastrointestinal stromal tumors at metastatic sites with or without imatinib treatment
Author(s)
S akamoto K, Sakurai S, Kanda T, Sakuma Y, Hishima T, Hironaka M, Bamba T, Keira Y, Takano Y, Niki T, Hasegawa T, Hirota S
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Journal Title
NAID
Related Report
Peer Reviewed
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