Analysis of the molecular mechanism in gastrointestinal pacemaker cell using KIT knock-in animal
| Project/Area Number |
19590411
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
ISOZAKI Koji Hyogo College of Medicine, 医学部, 非常勤講師 (00425117)
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| Co-Investigator(Kenkyū-buntansha) |
HIROTA Seiichi 兵庫医科大学, 医学部, 教授 (50218856)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 多発性GIST / ノックインマウス / カハールの介在細胞 / c-kit遺伝子 / 生殖系列 / 機能獲得性突然変異 / 遺伝子改変動物 / 消化管運動 / ペースメーカー / KIT / 多発製GIST / ノッタインマウス / exon 17 / exon17 |
|---|
| Research Abstract |
CADM1 is an adhesion molecule mediating nerve-mast cell interactions. It was demonstrated that both CADM1 protein and mRNA expressed in GISTs of human small intestine but not in GISTs of human stomach. These results suggested that types of ICCs which are considered to be an origin of GISTs are different between gastric and intestinal GISTs.
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Report
(6 results)
Research Products
(14 results)
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[Journal Article] In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice2009
Author(s)
Ishikawa T, Nakai N, Liu NN, Shiba K, Isozaki K, Matsuda I, Ito T, Fujimoto J, Hatakeyama K, Kanda T, Hirota S
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Journal Title
Lab Invest 89
Pages: 1161-1168
Related Report
Peer Reviewed
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