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Role of macrophage mannose receptor in malaria

Research Project

Project/Area Number 19590426
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Parasitology (including Sanitary zoology)
Research InstitutionKyoto Institute of Technology

Principal Investigator

KAMEI Kaeko  Kyoto Institute of Technology, 工芸科学研究科, 准教授 (00214544)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords感染症 / 寄生虫 / マラリア / マクロファージマンノースレセプター / 脳マラリア / サイトカイン
Research Abstract

マクロファージマンノースレセプター(MR)は、マウスにおいてマラリアの重症化に関与している。その重症化機構をサイトカインの産生量に着目して検討した結果、MRは炎症性サイトカインの発現を誘導することを明らかにした。よって、MRによるマラリアの重症化機構は過剰な炎症反応の惹起であると考えられた。さらに、ブタMRを用いて、MRと感染赤血球成分がマンノースを介して結合することを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (1 results)

  • [Journal Article] Effects of amino acids on malarial heme crystallization2008

    • Author(s)
      D.T. Uyen, N.T. Huy, D.T.X. Trang, N.T. Nhien, T. Oida, K. Hirayama, S. Harada, and K. Kamei
    • Journal Title

      Biol Pharm Bull 31(8)

      Pages: 1483-1488

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of amino acids on malarial heme crystallization.2008

    • Author(s)
      D. T. Uyen
    • Journal Title

      Biol Pharm Bull. 31(8)

      Pages: 1483-1488

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2-tert-Butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization2007

    • Author(s)
      N.T. Huy, K. Mizunuma, K. Kaur, K, Kaur, N.T.T.Nhien, M. Jain, D.T. Uyen, S. Harada, R. jain, and K. Kamei
    • Journal Title

      Antimicrobial Agents and Chemotherapy 51(8)

      Pages: 2842-2847

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alcohols induce beta-hematinformation via the dissociation of aggregated heme and reduction in interfacial tension of the solution2007

    • Author(s)
      N.T. Huy, A. Maeda, D.T. Uyen, D.T.X.Trang, M. Sasai, T.shiono, T.Oida, S. harada, and K. kamei
    • Journal Title

      Acta Tropica 101(2)

      Pages: 130-138

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds2007

    • Author(s)
      Nguyen Tien Huy, Dinh Thanh Uyen, Atsushi Maeda, Dai Thi Xuan Trang, Tatsuo Oida, Shigeharau Harada, and Kaeko Kamei
    • Journal Title

      Antimicrobial Agents and Chemotherapy 51(1)

      Pages: 350-353

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 8-Quinolinamines Containing 2-tert-buty1 Group Exhibits Potent Blood-schizontocidal Antimalarial Activities via Inhibition of the Heme Catabolism.2007

    • Author(s)
      N. T. Huy, K. Mizunuma, K. Kaur, N. T. T. Nhien, M. Jain, D. T. Uyen, S. Harada, R. Jain, and K. Kamei
    • Journal Title

      Antimicrobial Agents and Chemotherapy, 51(8)

      Pages: 2842-2847

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alcohols induce beta-hematin formation via the dissociation of aggregated heme and reduction in interfacial tension of the solution.2007

    • Author(s)
      N. T. Huy, A. Maeda, D. T. Uyen, D. T. X. Trang, M. Sasai, T. Shiono, T. Oida, S. Harada, and K. Kamei
    • Journal Title

      Acta Tropica 101(2)

      Pages: 130-138

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds.2007

    • Author(s)
      N. T. Huy, D. T. Uyen, A. Maeda, D. T. X. Trang, T. Oida, S. Harada, and K. Kamei
    • Journal Title

      Antimicrobial Agents and Chemotherapy 51(1)

      Pages: 350-353

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] マラリア色素形成における脂質の役割2008

    • Author(s)
      前田篤志、N. T. Huy、水沼敬典、嶋祐介、笹井基裕、D. T. Uyen、N. T. T. Nhien、原田繁春、亀井加恵子
    • Organizer
      日本寄生虫学会
    • Place of Presentation
      長崎市
    • Year and Date
      2008-04-03
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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