Studies on the molecular mechanism of emesis and emetic receptor of staphylococcal enterotoxin
| Project/Area Number |
19590438
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Bacteriology (including Mycology)
|
|---|
| Research Institution | Hirosaki University |
|---|
Principal Investigator |
HU Dong-liang Hirosaki University, 大学院・医学研究科, 准教授 (10333733)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKANE Akio 弘前大学, 大学院・医学研究科, 教授 (30164239)
|
|---|
| Project Period (FY) |
2007 – 2008
|
| Project Status |
Completed (Fiscal Year 2008)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 病原性 / エンテロトキシ / ブドウ球菌エンテロトキシン / スーパー抗原 / 嘔吐活性 / メカニズム / レセプター |
|---|
| Research Abstract |
黄色ブドウ球菌の産生するエンテロトキシン(SE)は菌体外タンパク毒素で嘔吐誘導活性を示す一方,スーパー抗原活性を有することが知られている.しかし,SEによる食中毒のメカニズムはまだ明らかにされていない.本研究では, 小型嘔吐動物モデル・スンクスを用いSEAの催吐メカニズム及び細胞レセプターを検討した.これらの結果により, 小腸の5-HTの産生と放出,迷走神経求心性ニューロンの5-HT3 レセプターはSEAによる嘔吐反応に重要であり, またCB1レセプターは5-HTの産生と放出を抑制することによりSEAによる嘔吐反応を制御することが示唆された
|
Report
(3 results)
Research Products
(53 results)
-
-
-
-
-
-
-
[Journal Article] Comparative prevalence of superantigenic toxin genes in methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates2008
Author(s)
Hu, D.-L., Omoe, K., Inoue, F., Kasai,T., Yasujima, M., Shinagawa, K. and Nakane, A.
-
Journal Title
J.Med.Microbiol 57(9)
Pages: 1106-1112
Related Report
Peer Reviewed
-
[Journal Article] Identification and characterization of two novel staphylococcal enterotoxins types Sand T.2008
Author(s)
Ono, H., Omoe, K., Imanishi, K., Iwakabe, Y., Hu, D.-L., Kato, H., Saito, N., Nakane, A., Uchiyama, T. and Shinagawa, K.
-
Journal Title
Infect.Immun 76(11)
Pages: 4999-5005
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Staphylococcal enterotoxin induces emesis through increasing serotonin release inintestine and it is down-regulated by cannabinoid receptor 12007
Author(s)
Hu, D.-L., Zhu, G., Mori, F., Omoe, K., Kaneko, S., Wakabayashi, K., Shinagawa, K. and Nakane, A.
-
Journal Title
Cell. Microbiol 9(9)
Pages: 2267-2277
Related Report
Peer Reviewed
-
-
[Journal Article] Staphylococcal enterotoxin A modulates intracellular Ca^<2+> signal pathway in human intestinal epithelial cells2007
Author(s)
Hu, D.-L., Suga, Y., Omoe, K., Abe, Y., Shinagawa, K., Wakui, M. and Nakane, A.
-
Journal Title
Hirosaki Med. J. 59(S)
Pages: 219-226
NAID
Related Report
Peer Reviewed
-
-
[Journal Article] Pollution of enteropatho-genic bacteria in meats and egg in Japan and China2007
Author(s)
Hu, D.-L., Qian, A.-D., San, X.-F., Narita, K, Sashinami, H, Osanai, A., Abe, Y., Hiraga, Kudou, K., Liu, Y. and Nakane, A.
-
Journal Title
Hirosaki Med. J. 59(1)
Pages: 1-6
Related Report
Peer Reviewed
-
-
-
-
[Presentation] Immunization with nontoxic mutant staphylococcal enterotoxin A protects against enterotoxin-induced emesis in house musk shrews2009
Author(s)
Hu, D.-L., Omoe, K., Sashinami, H., Shinagawa, K., Nakane, A.
Organizer
The 11th Meeting Hirosaki International Forum of Medical Science
Place of Presentation
Hirosaki, Japan
Related Report
-
-
-
-
-
-
-
-
-
-
[Presentation] Vaccination with nontoxic mutant staphylococcal enterotoxin A, D227A, protects against enterotoxin-induced emesis in housemusk shrews2008
Author(s)
Hu, D.-L., Omoe, K., Sashinami, H., Shinagawa, K., Nakane, A.
Organizer
第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
Place of Presentation
神戸
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 日本と中国における急性胃腸炎起因微生物の汚染調査2007
Author(s)
胡東良, 銭愛東, 差波拓志, 単暁風, 成田浩司, 長内理大, 阿部由紀子, 平賀寛人, 工藤幸清, 劉勇, 中根明夫
Organizer
青森感染症研究会
Place of Presentation
青森
Year and Date
2007-06-23
Related Report
-
-
-
-
-
