• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular analyses of a Legionella ubiquitin ligase.

Research Project

Project/Area Number 19590446
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionOsaka University

Principal Investigator

NAGAI Hiroki (2008)  Osaka University, 微生物病研究所, 特任准教授 (80222173)

久堀 智子 (2007)  Osaka University, 微生物病研究所, 特任助教 (20397657)

Co-Investigator(Kenkyū-buntansha) 永井 宏樹  大阪大学, 微生物病研究所, 特任准教授 (80222173)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsレジオネラ / IV型分泌 / LubX / ユビキチン / プロテアソーム / エフェクター / 病原細菌 / ユビキチンリガーゼ / MALDI-TOF / IV型分泌系
Research Abstract

肺炎を引き起こす病原菌であるレジオネラは、多数の細菌由来タンパク質(エフェクター)を宿主細胞に注入することにより、宿主細胞をハイジャックする。本研究ではそのようなエフェクターの一つで、宿主細胞内のタンパク質分解系をハイジャックするLubXと結合するレジオネラタンパク質の探索を行った。驚いたことに、LubXは別のエフェクターに結合し、宿主のタンパク質分解系と共同して、その時間的制御を司ることが明らかとなった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (17 results)

All 2009 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (15 results)

  • [Journal Article] Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions2008

    • Author(s)
      Tomoko Kubori, Akihiro Hyakutake, Hiroki Nagai
    • Journal Title

      Mol.Microbiol 67

      Pages: 1307-1319

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions.2008

    • Author(s)
      Tomoko Kubori
    • Journal Title

      Mol. Microbiol. 67(6)

      Pages: 1307-1319

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effector regulating effector : A Legionella pneumophila metaeffector that temporally regulates proteasomal degradation of another effector in the host cytosol2009

    • Author(s)
      Tomoko Kubori
    • Organizer
      The 9th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji.Japan
    • Year and Date
      2009-09-09
    • Related Report
      2008 Final Research Report
  • [Presentation] レジオネラDot/Icm IV型分泌系により輸送されるエフェクターの時間的制御2009

    • Author(s)
      永井宏樹
    • Organizer
      第82回日本細菌学会総会ワークショップ
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-14
    • Related Report
      2008 Final Research Report
  • [Presentation] レジオネラDot/Icm IV型分泌系により輸送されるエフェクターの時間的制御2009

    • Author(s)
      永井宏樹
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-03-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Temporal regulation of a Legionella effector directed by a bacterial E3 ubiquitin ligase2009

    • Author(s)
      久堀智子, 永井宏樹
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Temporal regulation of a Legionella effector directed by a bacterial E3 ubiquitin ligase.2009

    • Author(s)
      久堀智子, 永井宏樹
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-03-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Dot/Icm Type IV secretion system and effector proteins : essential players in Legionella infection2009

    • Author(s)
      Hiroki Nagai
    • Organizer
      Japan-Mexico Workshop on “Pharmacobiology" and “Nanobiology"
    • Place of Presentation
      Mexico City, Mexico
    • Year and Date
      2009-02-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] A Legionella E3 ubiquitin ligase and its function in infected host cells.2009

    • Author(s)
      Hiroki Nagai
    • Organizer
      INRA-JSPS workshop “Molecular Dialogue of bacteria with the host"
    • Place of Presentation
      Paris, France
    • Year and Date
      2009-01-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effector regulating effector : A Legionella pneumophila metaeffector that temporally regulates proteasomal degradation of another effector in the host cytosol2009

    • Author(s)
      Tomoko Kubori, Naoaki Shinzawa, Hirotaka Kanuka, Hiroki Nagai
    • Organizer
      Gordon Research Conference "Microbial Adhesion & Signal Transduction
    • Place of Presentation
      New Port RI, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] The Dot/Icm Type IV secretion system and effector proteins2009

    • Author(s)
      Hiroki Nagai
    • Organizer
      Mexico-Japan Workshop "Bacterial Physiology and Biophysics
    • Place of Presentation
      Mexico City, Mexico
    • Related Report
      2008 Final Research Report
  • [Presentation] A Legionella E3 ubiquitin ligase and its function in infected host cells2009

    • Author(s)
      Hiroki Nagai
    • Organizer
      INRA-JSPS workshop "Molecular Dialogue of bacteria with the host"
    • Place of Presentation
      Paris, France
    • Related Report
      2008 Final Research Report
  • [Presentation] A Legionella E3 ubiquitin ligase and its function in infected host cells.2008

    • Author(s)
      Hiroki Nagai, Tomoko Kubori, Akihiro Hyakutake.
    • Organizer
      Current Trends in biomedicine workshop “Bacterial type IV secretion systems in human diseases"
    • Place of Presentation
      Baeza, Spain
    • Year and Date
      2008-10-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] A Legionella E3 ubiquitin ligase and its function in infected host cells2008

    • Author(s)
      Tomoko Kubori, Hyakutake Akihiro, Hiroki Nagai
    • Organizer
      The 8th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Japan
    • Year and Date
      2008-09-09
    • Related Report
      2008 Final Research Report
  • [Presentation] A Legionella E3 ubiquitin ligase and its function in infected host cells2008

    • Author(s)
      Tomoko Kubori, Akihiro Hyakutake, Hiroki Nagai
    • Organizer
      Current Trends in Biomedicine Workshop "Bacterial TypeIV Secretion Systems in Human Disease"
    • Place of Presentation
      Baeza, Spain
    • Related Report
      2008 Final Research Report
  • [Presentation] Akihiro Hyakutake Molecular analysis of Legionella type IV effectors2008

    • Author(s)
      Hiroki Nagai, Tomoko Kubori
    • Organizer
      第81回日本細菌学会総会国際シンポジウム
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions2007

    • Author(s)
      Tomoko Kubori, Hiroki Nagai
    • Organizer
      The 7th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Japan
    • Year and Date
      2007-09-04
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi