Crucial role for CD69 in the development of inflammation
Project/Area Number |
19590491
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Immunology
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Research Institution | Yamaguchi University (2008) Chiba University (2007) |
Principal Investigator |
HASEGAWA Akihiro Yamaguchi University, 大学院・医学系研究科, 講師 (80376376)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 接着分子 / CD69 / 喘息 / 炎症 / コレセプター / 腸炎 / 免疫学 |
Research Abstract |
CD69分子は早期活性化マーカー分子としてリンパ球の活性化の指標として広く用いられているが、機能の詳細は明らかにされていない。本研究では、アレルギー性喘息および腸炎モデルを用いてCD69分子の役割とその発現様式に関する解析を行った。その結果、炎症部位に浸潤しているほとんどの炎症細胞でCD69の発現が見られ、CD69ノックアウトマウスではアレルギー性喘息や腸炎が起こらないことが明らかとなった。さらにこれらの炎症モデルにおいては、T細胞上のCD69分子が炎症の誘導に重要であることが明らかとなった。
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Report
(3 results)
Research Products
(35 results)
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[Journal Article] Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene2008
Author(s)
Yamashita, M., Kuwahara, M., Suzuki,A., Hirahara, K., Shinnakasu, R.,Hosokawa, H., Hasegawa, A., Motohashi,S., Iwama, A. and Nakayama, T.
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Journal Title
J. Exp.Med. 205
Pages: 1109-20
Related Report
Peer Reviewed
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[Journal Article] Human byLipoarabinomannan/Lipomannan fromMycobactrium bovis BCG Tokyo-1722008
Author(s)
Ito, T., Hasegawa, A., Hosokawa, H., Yamashita, M., Motohashi, S., Naka, T., Okamoto, Y., Fujita, Y., Ishii, Y.,Taniguchi, M., Yano, I. and Nakayama, T.
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Journal Title
Int. Immunol. 20
Pages: 849-860
Related Report
Peer Reviewed
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[Journal Article] Lymphoid enhancer factor interactswith GATA-3 and controls its functionin T helper type2 cells2008
Author(s)
Hossain, M.B., Hosokawa, H., Hasegawa,A., Watarai, H., Taniguchi, M.,Yamashita, M. and Nakayama, T.
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Journal Title
Immunology 125
Pages: 377-386
Related Report
Peer Reviewed
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[Journal Article] ROG, repressor ofGATA, regulates Th2-driven allergicairway inflammation and airway hyperresponsiveness2008
Author(s)
Hirahara, K., Yamashita, M., Iwamura,C., Shinoda, K., Hasegawa, A.,Yoshizawa, H., Koseki, H., Gejyo, F.,and Nakayama, T.
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Journal Title
J. Allergy Clin. Immunol 122
Pages: 512-520
Related Report
Peer Reviewed
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[Journal Article] Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation2008
Author(s)
Shinnakasu, R., Yamashita, M.,Kuwahara, M., Hosokawa, H., Hasegawa,A., Motohashi, S. and Nakayama, T.
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Journal Title
J. Biol. Chem 283
Pages: 28216-28225
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Peer Reviewed
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[Journal Article] Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells2007
Author(s)
Kaneko, T., Hosokawa, H., Yamashita,M., Wang, C., Hasegawa, A., Kimura, Y.M., Kitajima, M., Kimura, F., Miyazaki,M. and Nakayama, T.
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Journal Title
Mol. Immunol 44
Pages: 2249-2256
Related Report
Peer Reviewed
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[Journal Article] Schnurri-2 controls memory Th1 and th2 cell numbers in vivo2007
Author(s)
Kimura, Y. M., Iwamura, C., Suzuki, A.,Miki, T., Hasegawa, A., Sugaya, K.,Yamashita, M., Ishii, S. and Nakayama,T.
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Journal Title
J. Immunol 178
Pages: 4926-4936
Related Report
Peer Reviewed
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[Journal Article] Schnurri-2 controls the generation of memory Th1 and Th2 cells2007
Author(s)
Kimura, Y.M., Iwamura, C., Suzuki, A.,Kitajima, M., Hosokawa, H., Hasegawa, A., Yamashita, M., and Nakayama, T.
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Journal Title
13th International congress of Immunology
Pages: 475-479
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[Journal Article] Schnurii-2 regulates Th2-dependent airway inflammation and aireway hyperresponsiveness2007
Author(s)
Iwamura, C., Kimura, Y. M., Shinoda,K., Endo, Y., Hasegawa, A., Yamashita,M. and Nakayama, T.
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Journal Title
Int. Immunol 19
Pages: 755-762
Related Report
Peer Reviewed
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[Presentation] BCGTokyo-172から分離精製したLAM/LM 分子によるHuman Th1分化誘導機構/Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-1722008
Author(s)
Ito, T., Hirasaki, Y., Hasegawa, A.,Hosokawa, H., Motohashi, S.,Yamashita, M., Ishii, Y., Taniguchi,M., Yano, I. and Nakayama, T.
Organizer
第38回日本免疫学会総会・学術集会
Place of Presentation
京都
Related Report
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