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Molecular mechanisms of lymphocyte migration to the skin and its regulation

Research Project

Project/Area Number 19590496
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionOsaka University

Principal Investigator

HIRATRA Takako  Osaka University, 微生物病研究所, 特任准教授 (00346199)

Co-Investigator(Kenkyū-buntansha) SHIGETA Akiko  大阪大学, 微生物病研究所, 特任研究員 (50420435)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsT細胞 / 接着分子 / セレクチン / シアロムチン / CD43 / PSGL-1 / 皮膚 / 白血球ローリング
Research Abstract

体の外面を覆う皮膚に浸潤するT 細胞は感染防御において中心的役割を担うだけでなく、アトピー性皮膚炎などの炎症性皮膚疾患の病因・病態にも関与する。その浸潤は血管内皮細胞上のセレクチンとT 細胞上のセレクチンリガンドとの相互作用により開始されるが、その分子レベルでの詳細は不明であった。本研究では、T 細胞上のセレクチンリガンドとしてPSGL-1、CD43、ESL-1 を同定し、これらの分子が協同的にT 細胞の皮膚浸潤を媒介することを明らかにした

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (27 results)

All 2008 2007 Other

All Journal Article (14 results) (of which Peer Reviewed: 12 results) Presentation (10 results) Remarks (3 results)

  • [Journal Article] An L-selectin ligand distinct from Pselectinglycoprotein ligand-1 is expressed onendothelial cells and promotes neutrophilrolling in inflammation.2008

    • Author(s)
      Shigeta, A., Matsumoto, M., Tedder, T.F., Lowe, L.B., Miyasaka, M., and Hirata, T
    • Journal Title

      Blood 112

      Pages: 4915-4923

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] T 細胞の炎症局所への動員におけるCD43 の生理的役割2008

    • Author(s)
      松本真典, 平田多佳子
    • Journal Title

      臨床免疫・アレルギー科 442

    • NAID

      40016324085

    • Related Report
      2008 Final Research Report
  • [Journal Article] Nepmucin/CLM-9, an Ig domain-containingsialomucin in vascular endothelial cells, promotes lymphocyte transendothelialmigration in vitro2008

    • Author(s)
      Jin, S., Umemoto, E., Tanaka, T., Shimomura, Y., Tohya, K., Kunizawa, K., Yang, B.G., Jang, M.H., Hirata, T., and Miyasaka, M.
    • Journal Title

      FEBS Lett 582

      Pages: 3018-3024

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD43 plays bothantiadhesive and proadhesive roles inneutrophil trafficking in a context-dependentmanner2008

    • Author(s)
      Matsumoto, M., Shigeta, A., Miyasaka, M., and Hirata, T
    • Journal Title

      J. Immunol 181

      Pages: 3628-3635

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chondroitinsulfate E fragments enhance CD44 cleavageand CD44-dependent motility in tumor cells.2008

    • Author(s)
      Sugahara, K.N., Hirata, T., Tanaka, T., Ogino, S., Takeda, M., Terasawa H., Shimada, I., Tamura, J., ten Dam, G.B., van Kuppevelt, T.H., and Miyasaka, M
    • Journal Title

      Cancer Res 68

      Pages: 7191-7199

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel isoforms ofmouse L-selectin with different carboxyterminaltails2008

    • Author(s)
      Furukawa, Y., Umemoto, E., Jang, M.H., Tohya, K., Miyasaka, M., and Hirata, T
    • Journal Title

      J. Biol. Chem 283

      Pages: 12112-12119

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD4+CD25+ regulatory T cells in the smallintestinal lamina propria show aneffector/memory phenotype2008

    • Author(s)
      Guo, Z., Jang, M.H., Otani, K., Bai, Z., Umemoto, E., Matsumoto, M., Nishiyama, M., Yamasaki, M., Ueha, S., Matsushima, K., Hirata, T., and Miyasaka, M
    • Journal Title

      Int. Immunol 20

      Pages: 307-315

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel isoforms of mouse L-selectin with different carboxy-terminal tails2008

    • Author(s)
      Furukawa, Y.
    • Journal Title

      Journal of Biological Chemistry 283

      Pages: 12112-1211

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chondroitin sulfate E fragments enhance CD44 cleavage and CD44-dependent motility in tumor cells2008

    • Author(s)
      Sugahara, K. N.
    • Journal Title

      Cancer Research 68

      Pages: 7191-7199

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD43 plays both antiadhesive and proadhesive roles in neutrophil trafficking in a context-dependent manner2008

    • Author(s)
      Matsumoto, M.
    • Journal Title

      Journal of Immunology 181

      Pages: 3628-3635

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nepmucin/CLM-9, an Ig domain-containing sialomucin in vascular endothelial cells, promotes lymphocyte transendothelial migration in vitro2008

    • Author(s)
      Jin, S.
    • Journal Title

      FEBS Letters 582

      Pages: 3018-3024

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation2008

    • Author(s)
      Shigeta, A.
    • Journal Title

      Journal of Immunology 112

      Pages: 4915-4923

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T細胞の炎症局所への動員におけるCD43の生理的役割2008

    • Author(s)
      松本真典
    • Journal Title

      臨床免疫・アレルギー科 50

      Pages: 437-442

    • Related Report
      2008 Annual Research Report
  • [Journal Article] CD4^+ CD25^+ regulatory T cells in the small intestinal lamina propria show an effector/memory phenotype2008

    • Author(s)
      Guo, Z.
    • Journal Title

      International Immunology 20

      Pages: 307-315

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] M. PSGL-1 negatively regulates T cell immune responses in vivo.2008

    • Author(s)
      Matsumoto, M
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Pripheral lymphopenia in moesin-deficient mice2008

    • Author(s)
      Serigano, N
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] PSGL-1 negatively regulates T cell immune responses in vivo2008

    • Author(s)
      Matsumaoto, M.
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Peripehral lymphopenia in moesin-deficient mice2008

    • Author(s)
      Serigano, N.
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] CD4^+CD25^+ regulatory T cells in the small intestinal lamina propria show an effector/memory phenotype2007

    • Author(s)
      Guo, Z.
    • Organizer
      第37回日本免疫学会総会・学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] An atni-adhesive role of PSGL-1 in T cells2007

    • Author(s)
      Matsumoto, M
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] An endothelial L-selectin is important for E-selectin-mediated neutrophil rolling in inflammation2007

    • Author(s)
      Shigeta, A
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] CD4+CD25+ regulatory T cells in thesmall intestinal lamina propria show aneffector/memory phenotype2007

    • Author(s)
      Guo, Z
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] An anti-adhesive role of PSGL-1 on T cells2007

    • Author(s)
      Matsumoto, M.
    • Organizer
      第37回日本免疫学会総会・学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] An endothelial L-selectin ligand is important for E-selectin-mediated neutrophil rolling in inflammation2007

    • Author(s)
      Shigeta, A.
    • Organizer
      第37回日本免疫学会総会・学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/act/act_hirata.php

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/act/act_hirata.php

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/COE/project/pro14.htm1

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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