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Mechanisms in the augmentation of type I interferon production by PDC-TREM, a novel plasmacytoid dendritic cell specific receptor

Research Project

Project/Area Number 19590502
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

WATARAI Hiroshi  The Institute of Physical and Chemical Research, 免疫制御研究グループ, 上級研究員 (70415339)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords形質細胞様樹状細胞 / インターフェロン / 生体防御 / ウイルス / Toll様受容体 / プレキシン / セマフォリン / セマアフォリン
Research Abstract

申請者は、活性化PDC形質細胞様樹状細胞特異的膜分子であるPDC-TREMを発見し、PDC-TREMがToll様受容体による核酸成分認識後のIFN産生調節に重要な役割を担っていること、を明らかにした。PDC-TREMに対する特異的モノクローナル抗体を複数樹立することに成功し、抗体処理によるI型IFN産生の著しい産生抑制を見出した。一方、リガンドであるSemaphorinを作用させることにより、PDC-TREM依存的にI型IFNが産生されることも見出した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (41 results)

All 2009 2008 2007 2000 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (9 results) Book (3 results) Remarks (2 results) Patent(Industrial Property Rights) (6 results)

  • [Journal Article] Identification of progenitors differentiating into mature NKT cells in the culture of NKT cell cloned ES cells2009

    • Author(s)
      Watarai H, Rybouchkin A, Nagata Y, Nyambayar D, Hongo N, Sakata S, Sekine E, Kakimoto K, Fujii S, Shimizu K, Kawamoto H, Koseki H, Taniguchi M
    • Journal Title

      Blood (in press)

      Pages: 0-0

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methods for detection, isolation and culture of mouse and human invariant NKT cells2008

    • Author(s)
      Watarai H, Nakagawa R, Omori-Miyake M, Dashtsoodol N, Taniguchi M
    • Journal Title

      Nat Protoc. 3

      Pages: 70-78

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon2008

    • Author(s)
      Watarai H, Sekine E, Inoue S, Nakagawa R, Kaisho T, Taniguchi M.
    • Journal Title

      Proc Natl Acad Sci USA. 105

      Pages: 2993-2998

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells2008

    • Author(s)
      Hossain MB, Hosokawa H, Hasegawa A, Watarai H, Taniguchi M, Yamashita M, Nakayama T
    • Journal Title

      Immunology. 125

      Pages: 377-386

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] RCAI-17, 22, 24-26, 29, 31, 34-36, 38-40, and 88, the analogs of KRN7000 with a sulfonamide linkage: Their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines2008

    • Author(s)
      Tashiro T, Hongo N, Nakagawa R, Seino KI, Watarai H, Ishii Y, Taniguchi M, Mori K
    • Journal Title

      Bioorg Med Chem. 16

      Pages: 8896-8906

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] RCAI-61, the 6'-methylated analog of KRN7000: its synthesis and potent activity for mouse lymphocytes to produce interferon-γ in vivo2008

    • Author(s)
      Tashiro T, Nakagawa R, Inoue S, Shiozaki M, Watarai H, Taniguchi M, Mori K
    • Journal Title

      Tetrahedron Lett. 49

      Pages: 6827-6830

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity2008

    • Author(s)
      Terashima A, Watarai H, Inoue S, Sekine E, Nakagawa R, Hase K, Iwamura C, Nakajima H, Nakayama T, Taniguchi M
    • Journal Title

      J Exp Med. 205

      Pages: 2727-2733

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells2008

    • Author(s)
      Hossain MB, et al
    • Journal Title

      Immunology 125

      Pages: 377-386

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RCAI-17, 22, 24-26, 29, 31, 34-36, 38-40, and 88, the analogs of KRN7000 with a sulfonamide linkage : Their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines2008

    • Author(s)
      Tashiro T, et al
    • Journal Title

      Bioorg Med Chem. 16

      Pages: 8896-8906

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RCAI-61, the 6'-methylated analog of KRN7000 : its synthesis and potent activity for mouse lymphocytes to produce interferon-g in vivo2008

    • Author(s)
      Tashiro T, et al
    • Journal Title

      Tetrahedron Lett. 49

      Pages: 6827-6830

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of CD4-CD8-double-negative natural killer T cell precursors in the thymus2008

    • Author(s)
      Dashtsoodol N, et al
    • Journal Title

      PLoS ONE 3

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity.2008

    • Author(s)
      Terashima A, et al
    • Journal Title

      J Exp Med 205

      Pages: 2727-2733

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methods for detection, isolation, and culture of mouse and human invariant NKT cells.2008

    • Author(s)
      Watarai H, et. al.
    • Journal Title

      Nat Protoc 3

      Pages: 70-78

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon2008

    • Author(s)
      Watarai H, et. al.
    • Journal Title

      Proc Natl Acad Sci USA 105

      Pages: 2993-2998

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RCAI-56, a carbocyclic analogue of KRN7000: its synthesis and potent activity for natural killer (NK)T cell to preferentially produce interferon-γ2007

    • Author(s)
      Tashiro T, Nakagawa R, Hirokawa T, Inoue S, Watarai H, Taniguchi M, Mori K
    • Journal Title

      Tetrahedron Lett. 48

      Pages: 3343-3347

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells2007

    • Author(s)
      Hijikata A, Kitamura H, Kimura Y, Yokoyama R, Aiba Y, Bao Y, Fujita S, Hase K, Hori S, Ishii Y, Kanagawa O, Kawamoto H, Kawano K, Koseki H, Kubo M, Kurita-Miki A, Kurosaki T, Masuda K, Nakata M, Oboki K, Ohno H, Okamoto M, Okayama Y, O-Wang J, Saito H, Saito T, Sakuma M, Sato K, Sato K, Seino K, Setoguchi R, Tamura Y, Tanaka M, Taniguchi M, Taniuchi I, Teng A, Watanabe T, Watarai H, Yamasaki S, Ohara O
    • Journal Title

      Bioinformatics 23

      Pages: 2934-2941

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] RCAI-56, a carbocyclic analogue of KRN7000: its synthesis and potent activity for natural killer(NK)T cell to preferentially produce interferon-γ2007

    • Author(s)
      Tashiro T, et. al.
    • Journal Title

      Tetrahedron Letters 48

      Pages: 3343-3347

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells.2007

    • Author(s)
      Hijikata A, et. al.
    • Journal Title

      Bioinformatics 23

      Pages: 2934-2941

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] I{kappa}B kinase induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formiation in B cells.2007

    • Author(s)
      Shinohara H, et. al.
    • Journal Title

      J Exp Med 204

      Pages: 3285-3293

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells2000

    • Author(s)
      Shinohara H, Maeda S, Watarai H, Kurosaki T
    • Journal Title

      J Exp Med. 204

      Pages: 3285-3293

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of CD4-CD8- double-negative natural killer T cell precursors in the thymus

    • Author(s)
      Nyambayar D, Watarai H, Sakata S, Taniguchi M
    • Journal Title

      PLoS ONE 3(11)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon2009

    • Author(s)
      Watarai H, et al
    • Organizer
      Keystone Symposia : Allergy and Asthma
    • Place of Presentation
      Keystone Resort
    • Year and Date
      2009-01-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity2009

    • Author(s)
      Watarai H et al
    • Organizer
      Keystone Symposia: Allergy and Asthma/Fibrosis
    • Place of Presentation
      Keystone USA
    • Related Report
      2008 Final Research Report
  • [Presentation] PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon2008

    • Author(s)
      Watarai H, et al
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-12-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] PDC-TREM,a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon2008

    • Author(s)
      Watarai H, et. al.
    • Organizer
      Keystone Symposia:Innate Immunity-signaling mechanisms
    • Place of Presentation
      Keystone Resort,Colorado,USA
    • Year and Date
      2008-02-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] A novel plasmacytoid dendritic cell-specific receptor, PDC-TREM, is responsible for augmented production of type I interferon2008

    • Author(s)
      Watarai H et al
    • Organizer
      Keystone Symposia: Innate Immunity: Signaling Mechanisms
    • Place of Presentation
      Keystone USA
    • Related Report
      2008 Final Research Report
  • [Presentation] A novel plasmacytoid dendritic cell-specific receptor, PDC-TREM, is responsible for augmented production of type I interferon2008

    • Author(s)
      Watarai H et al
    • Organizer
      10th International Symposium on Dendritic Cells
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] A novel plasmacytoid dendritic cell-specific receptor, PDC-TREM, is responsible for augmented production of type I interferon2008

    • Author(s)
      Watarai H et al
    • Organizer
      第38回日本免疫学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] PDC-TREM,a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon2007

    • Author(s)
      Watarai H, et. al.
    • Organizer
      日本免疫学会
    • Place of Presentation
      東京・高輪プリンスホテル
    • Year and Date
      2007-11-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] A novel plasmacytoid dendritic cell-specific receptor, PDC-TREM, is responsible for augmented production of type I interferon2007

    • Author(s)
      Watarai H et al
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Book] ウイルス感染を防御する〓型インターフェロン産生を増強するしくみ、MedicalBio 5:14-152008

    • Author(s)
      渡会浩志
    • Publisher
      オーム社
    • Related Report
      2008 Final Research Report
  • [Book] CD1dによる糖脂質抗原提示と免疫調節機構、蛋白質核酸酵素、53:1584-15892008

    • Author(s)
      渡会浩志、共立出版、田代卓哉、千葉朋希、谷口克
    • Related Report
      2008 Final Research Report
  • [Book] ウイルス感染に対する生体防御反応におけるPDC-TREMの役割:創薬ターゲットとしての可能性、化学と生物、46:750-7522008

    • Author(s)
      渡会浩志
    • Publisher
      日本農芸化学会
    • Related Report
      2008 Final Research Report
  • [Remarks] ホームページ

    • URL

      http://web.rcai.riken.jp/en/labo/regulation/index.html

    • Related Report
      2008 Final Research Report
  • [Remarks] 研究成果のURL

    • URL

      http://www.riken.go.jp/r-world/info/release/press/2008/080219/index.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] B細胞由来iPS細胞およびそれ由来のB細胞2008

    • Inventor(s)
      渡会浩志他
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Filing Date
      2008-09-04
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] NKT細胞由来iPS細胞およびそれ由来のNKT細胞2008

    • Inventor(s)
      渡会浩志他
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Filing Date
      2008-09-04
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] B細胞由来iPS細胞およびその用途2008

    • Inventor(s)
      渡会浩志, 他
    • Industrial Property Rights Holder
      理化学研究所
    • Filing Date
      2008-09-04
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] NKT細胞由来iPS細胞およびそれ由来のNKT細胞2008

    • Inventor(s)
      渡会浩志, 他
    • Industrial Property Rights Holder
      理化学研究所
    • Filing Date
      2008-09-08
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] IL-17RB陽性NKT細胞を用いたアレルギー性気道炎症及び/又は気道過敏症の治療薬のスクリーニング法2007

    • Inventor(s)
      渡会浩志他
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Filing Date
      2007-11-28
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] IL-17RB陽性NKT細胞を用いたアレルギー性気道炎症及び/又は気道過敏症の治療薬のスクリーニング法2007

    • Inventor(s)
      渡会 浩志
    • Industrial Property Rights Holder
      理研
    • Filing Date
      2007-11-28
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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