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Analysis for the function of adaptor protein, BANK which negatively regulates immune response

Research Project

Project/Area Number 19590503
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

AIBA Yuichi  The Institute of Physical and Chemical Research, 分化制御研究グループ, 研究員 (00273516)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsB細胞 / アダプター分子
Research Abstract

B細胞応答を負に制御するアダプター分子であるBANKについて、その制御機構、また免疫抑制の意義について解析した。BANKに刺激依存的に結合する85kdの未知のタンパクを発見した。また免疫寛容の誘導時にBANKが関与するかについて、種々の遺伝子改変マウスを用いて解析したが、BANKによる免疫応答の負の制御は免疫寛容の誘導には関与しないことが明らかとなった。一方BANKは抗原刺激後初期の細胞増殖を負に制御することが明らかとなった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (6 results)

All 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] A Minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical desease2008

    • Author(s)
      Conley ME., Farmer DM., Dobbs AK., Howard V., Aiba Y., Shurtleff SA., Kurosaki T.
    • Journal Title

      Clinical and Experimental Immunology Vol. 152

      Pages: 39-44

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase2008

    • Author(s)
      Aiba Y., Kameyama M., Yamazaki T., Tedder TF., Kurosaki T.
    • Journal Title

      Blood Vol. 111

      Pages: 1497-1503

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical disease2008

    • Author(s)
      Conley ME, et al
    • Journal Title

      Clinical and Experimental Immunology 152

      Pages: 39-44

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase2008

    • Author(s)
      Aiba Y, et. al.
    • Journal Title

      Blood 111

      Pages: 1497-1503

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] BCAP及びCD19分子によるB細胞分化の制御2007

    • Author(s)
      饗場 祐一
    • Organizer
      日本免疫学会総会 学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] BCAP及びCD19分子によるB細胞分化の制御2007

    • Author(s)
      饗場 祐一, 他
    • Organizer
      日本免疫学会総会.学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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