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Multi-center case series study of lung injury associated with novel drugs for rheumatoid arthritis treatment

Research Project

Project/Area Number 19590530
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KOIKE Ryuji  Tokyo Medical and Dental University, 医学部附属病院, 准教授 (50250220)

Co-Investigator(Kenkyū-buntansha) HARIGAI Masayoshi  東京医科歯科大学, 医歯学総合研究科, 客員教授 (20238207)
MIYASAKA Nobuyuki  東京医科歯科大学, 医歯学総合研究科, 教授 (30157622)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords医薬品副作用 / 抗リウマチ薬 / 関節リウマチ / ニューモシスチス肺炎 / 薬剤性肺炎 / 薬剤性肺障害 / エタネルセプト / タクロリムス / データベース / 間質性肺炎 / インフリキシマブ / 肺合併症 / レフルノミド
Research Abstract

We have studied pulmonary complications associated with novel drugs approved for rheumatoid arthritis treatment recently. We have focused on the Pneumocystis pneumonia under infliximab or etanercept treatment and drug-induced pneumonia under tacrolimus treatment. And we have constructed and arranged the database of Japanese rheumatoid arthritis patients, which is essential for the research of adverse reactions induced by anti-rheumatic drugs.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (47 results)

All 2009 2008 2007 Other

All Journal Article (16 results) (of which Peer Reviewed: 15 results) Presentation (22 results) Book (7 results) Remarks (2 results)

  • [Journal Article] Pneumocystis pneumonia in patients with rheumatoid arthritis treated with infliximab : a retrospective review and case-control study of 21 patients2009

    • Author(s)
      Komano Y, Harigai M, Koike R, 他22名
    • Journal Title

      Arthritis Care Res 15

      Pages: 305-12

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Postmarketing surveillance of the safety and effectiveness of etanercept in Japan2009

    • Author(s)
      Koike T, Harigai M, 他10名
    • Journal Title

      J Rheumatol 36

      Pages: 898-906

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Japan College of Rheumatology 2009 guidelines for the use of tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, in rheumatoid arthritis2009

    • Author(s)
      Koike R, Harigai M, Atsumi T, Amano K, Kawai S, Saito K, Saito T, Yamamura M, Matsubara T, Miyasaka N.
    • Journal Title

      Mod Rheumatol 19

      Pages: 351-7

    • NAID

      10025113303

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 臨床医にとっての医薬品安全性情報 : 医師は副作用に関心がないのか?2009

    • Author(s)
      小池竜司, 中山健夫
    • Journal Title

      薬剤疫学 14

      Pages: 89-98

    • NAID

      130000254990

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pneumocystis jiroveci pneumonia in patients with rheumatoid arthritis treated with infliximab : A retrospective review and case-control study of 21 patients.2009

    • Author(s)
      Komano Y, Harigai M, 小池竜司, 他
    • Journal Title

      Arthritis Care Res(Arthritis Rheum) 61

      Pages: 305-312

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japan College of Rheumatology 2009 guidelines for the use of to cilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, in rheumatoid arthritis.2009

    • Author(s)
      小池竜司, Harigai M, 他
    • Journal Title

      Mod Rheumatol 19

      Pages: 351-357

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 臨床医にとっての医薬品安全性情報:医師は副作用に関心がないのか?2009

    • Author(s)
      小池竜司、中山健夫
    • Journal Title

      薬剤疫学 14

      Pages: 89-98

    • NAID

      130000254990

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pneumocystis jiroveci pneumonia in patients with rheumatoid arthritis treated with infliximab : a retrospective review and case-controls tudy of 21 patients.2009

    • Author(s)
      Konano Y, et al.
    • Journal Title

      Arthritis Care and Research 61

      Pages: 305-312

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postmarketing surveillance of the safety profile of infliximab in 5000 Japanese patients with rheumatoid arthritis2008

    • Author(s)
      Takeuchi T, 他13名, Harigai M(8番目)
    • Journal Title

      Ann Rheum Dis 67

      Pages: 189-94

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] CHANGE Study Investigators Clinical investigation in highly disease-affected rheumatoid arthritis patients in Japan with adalimumab applying standard and general evaluation : the CHANGE study2008

    • Author(s)
      Miyasaka N
    • Journal Title

      Mod Rheumatol 18

      Pages: 252-62

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical investigation in highly disease-affeeted rheumatoid arthritis patients in Japan with adalimumab applying standard and general evaluation.2008

    • Author(s)
      Miyasaka N, et al.
    • Journal Title

      Modern Rheumatology 18

      Pages: 252-262

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生物学的製剤の適応とリスクマネージメント2008

    • Author(s)
      針谷正祥
    • Journal Title

      内科 101

      Pages: 698-703

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Pneumocystis pneumonia associated with infliximab in Japan2007

    • Author(s)
      Harigai M, Koike R, Miyasaka N.
    • Journal Title

      N Engl J Med 357

      Pages: 1874-6

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Update on the Japanese guidelines for the use of infliximab and etanercept in rheumatoid arthritis2007

    • Author(s)
      Koike R, Takeuchi T, Eguchi K, Miyasaka N.
    • Journal Title

      Mod Rheumatol 17

      Pages: 451-8

    • NAID

      10020177958

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pneumocystis pneumonia associated with infliximab in Japan.2007

    • Author(s)
      Harigai M, Koike R, Miyasaka N
    • Journal Title

      New England Journal of Medicine 357

      Pages: 1874-1876

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Update on the Japanese guidelines for the use of infliximab and etanercept in rheumatoid arthritis.2007

    • Author(s)
      Koike R, et. al.
    • Journal Title

      Modern Rheumatology 17

      Pages: 451-458

    • NAID

      10020177958

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Tacrolimus-Induced Pulmonary Injury in Patients with Rheumatoid Arthritis.2009

    • Author(s)
      Koike R, 他
    • Organizer
      第73回米国リウマチ学会年次総会
    • Place of Presentation
      米国フィラデルフィア
    • Year and Date
      2009-08-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Study Group for Tacrolimus-induced Pulmonary Injury. Tacrolimus-Induced Pulmonary Injury in Patients with Rheumatoid Arthritis2009

    • Author(s)
      Koike R, Tanaka M, Komano Y, Sakai F, Sugiyama H, Nanki T, Miyasaka N, Harigai M
    • Organizer
      American College of Rheumatology 73^<rd> National Meetings
    • Place of Presentation
      Philadelphia, PA
    • Related Report
      2009 Final Research Report
  • [Presentation] Pneumocystis jiroveci pneumonia associated with etanercept in patients with rheumatoid arthritis2009

    • Author(s)
      Tanaka M, Sakai R, Koike R, Komano Y, Nanki T, Miyasaka N, Harigai M.
    • Organizer
      Annual European Congress of Rheumatology EULAR
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2009 Final Research Report
  • [Presentation] Analysis of serious adverse events in patients with Rheumatoid arthritis under the treatment with biologics ; a report from the Registry of Japanese Rheumatoid Arthritis Patients for Long-term Safety2009

    • Author(s)
      Komano Y, Nanki T, Tanaka M, Sakai R, Koike R, Miyasaka N, Harigai M
    • Organizer
      Annual European Congress of Rheumatology EULAR
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2009 Final Research Report
  • [Presentation] Pneumocystis jiroveci pneumonia associated with etanercept in patients with rheumatoid arthritis2009

    • Author(s)
      Tanaka M, Sakai R, Koike R, Komano Y, Nanki T, Miyasaka N, Harigai M.
    • Organizer
      The 9th World Congress of Inflammation
    • Place of Presentation
      Tokyo
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチの薬物治療の進歩と今後の課題2009

    • Author(s)
      針谷正祥
    • Organizer
      平成21年度第1回日本内科学会生涯教育講演会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチにおける生物学的製剤の有効性とリスクマネージメント2009

    • Author(s)
      針谷正祥
    • Organizer
      日本薬学会 第129年会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 日本人関節リウマチ患者におけるタクロリムスの安全性2009

    • Author(s)
      針谷正祥
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] エタネルセプト投与下での関節リウマチ患者におけるニューモシスチス肺炎2009

    • Author(s)
      田中みち, 酒井良子, 駒野有希子, 南木敏宏, 小池竜司, 宮坂信之, 針谷正祥
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] リウマチ性疾患における生物学的製剤と重症感染症2009

    • Author(s)
      針谷正祥
    • Organizer
      第58回日本感染症学会(東日本地方会学術集会)・第56回日本化学療法学会(東日本支部総会)
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] TNF阻害薬使用下のニューモシスチス肺炎2008

    • Author(s)
      小池 竜司
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2008-04-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 日本における生物学的製剤使用関節リウマチ患者に関する疫学研究 (REAL研究) による生物学的製剤の安全性の検討 (中間報告)2008

    • Author(s)
      駒野有希子, 田中みち, 小池竜司, 他3名
    • Organizer
      第52回日本リウマチ学会総会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] リウマチ医のためのDMARDおよび生物学的製剤のファーマコビジランス-より良い関節リウマチ治療のための科学的な道標-2008

    • Author(s)
      針谷正祥
    • Organizer
      第52回日本リウマチ学会総会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] TNF阻害薬使用下のニューモシスチス肺炎2008

    • Author(s)
      小池竜司
    • Organizer
      第52回日本リウマチ学会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] Biologic Era における関節リウマチの呼吸器合併症2008

    • Author(s)
      針谷正祥
    • Organizer
      第65回東海呼吸器感染症研究会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] 医師の立場から見た医薬品の安全使用のための情報管理2008

    • Author(s)
      小池竜司
    • Organizer
      第62回国立病院総合医学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチに対するTNF阻害薬投与下におけるニューモシスチス肺炎発症の危険因子2008

    • Author(s)
      小池竜司
    • Organizer
      第1回臨床薬理研究振興財団研究報告会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] インフリキシマブ(IFX)投与下の関節リウマチ患者におけるニューモシスティス肺炎(PCP)発症危険因子の解析2007

    • Author(s)
      駒野有希子、針谷正祥、小池竜司, 他
    • Organizer
      第51回日本リウマチ学会総会・学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2007-04-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 生物学的製剤使用関節リウマチ患者登録システム (REAL) の集計結果と今後の課題2007

    • Author(s)
      小池竜司, 他4名
    • Organizer
      第51回日本リウマチ学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] インフリキシマブ (IFX) 投与下の関節リウマチ患者におけるニューモシスティス肺炎 (PCP) 発症危険因子の解析2007

    • Author(s)
      駒野有希子, 針谷正祥, 他3名
    • Organizer
      第51回日本リウマチ学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] TNF阻害薬の有効性と問題点2007

    • Author(s)
      針谷正祥
    • Organizer
      第19回日本アレルギー学会春季臨床大会イブニングシンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 生物学的製剤使用関節リウマチ患者における重篤な有害事象の解析2007

    • Author(s)
      針谷正祥
    • Organizer
      東京医科歯科大学21世紀COEプログラム「歯と骨の分子破壊と再構築のフロンティア」第10回公開講座
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Book] 生物学的製剤の適応と副作用よくわかる関節リウマチのすべて(宮坂信之編)2009

    • Author(s)
      針谷正祥
    • Publisher
      永井書店
    • Related Report
      2009 Final Research Report
  • [Book] 生物学的製剤で副作用が起こったら?~副作用の対処方法~正しい生物学的製剤の使い方 (関節リウマチ)(宮坂信之編)2009

    • Author(s)
      針谷正祥
    • Publisher
      医薬ジャーナル社
    • Related Report
      2009 Final Research Report
  • [Book] 関節リウマチの関節外症状 (肺・腎・アミロイドーシス) よくわかる関節リウマチのすべて(宮坂信之編)2009

    • Author(s)
      小池竜司
    • Publisher
      永井書店
    • Related Report
      2009 Final Research Report
  • [Book] 感染症 (PART4 リウマチ・膠原病の合併症) からだの科学256、リウマチ・膠原病のすべて(竹内勤編)2008

    • Author(s)
      針谷正祥
    • Publisher
      日本評論社
    • Related Report
      2009 Final Research Report
  • [Book] わが国における生物学的製剤使用ガイドライン 別冊・医学のあゆみ 関節リウマチのパラダイムシフト-生物学的製剤時代の最新治療動向-(宮坂信之編)2008

    • Author(s)
      小池竜司
    • Publisher
      医歯薬出版
    • Related Report
      2009 Final Research Report
  • [Book] 生物学的製剤使用ガイドライン 最新医学別冊「新しい診断と治療のABC(8) 関節リウマチ」(改訂第2版)(宮坂信之編)2008

    • Author(s)
      小池竜司
    • Publisher
      最新医学社
    • Related Report
      2009 Final Research Report
  • [Book] 別冊・医学のあゆみ「関節リウマチのパラダイムシフト -生物学的製剤時代の最新治療動向」2008

    • Author(s)
      小池 竜司(分担執筆)
    • Total Pages
      127
    • Publisher
      医歯薬出版
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等, 東京医科歯科大学・医歯学総合研究科・薬害監視学講座ホームページ

    • URL

      http://www.tmd.ac.jp/grad/phv/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/grad/phv/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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