Development of new chemotherapies against liver cancer on the basis of levels of transcription factor ID2
Project/Area Number |
19590536
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied pharmacology
|
Research Institution | Yamaguchi University |
Principal Investigator |
IIZUKA Norio Yamaguchi University, 大学院・医学系研究科, 准教授 (80332807)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | ID2 / 肝癌 / 転移 / 抗がん剤 / 門脈浸潤 |
Research Abstract |
肝癌(HCC)細胞におけるID2の発現量がヒストン脱アセチル化酵素(HDAC)阻害剤(ソディウムブチレート及びトリコスタチンA)の感受性と関連することを見出し、国内(第31回日本分子生物学会年会)および国際学会(The 19^(th) Conference of the Asian Pacific Association for the Study of the Liver)で発表し、現在、論文を投稿準備中である。
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Report
(3 results)
Research Products
(20 results)