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Role of transcription repressor Bach1 in cardiovascular diseases

Research Project

Project/Area Number 19590561
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionHiroshima University

Principal Investigator

ISHIDA Takafumi  Hiroshima University, 大学院・医歯薬学総合研究科, 講師 (40346482)

Co-Investigator(Kenkyū-buntansha) 大島 哲也  広島大学, 大学院・医歯薬学総合研究科, 准教授 (40233100)
田代 聡  広島大学, 原爆放射線医科学研究所, 教授 (20243610)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords酸化ストレス / 動脈硬化 / 血管
Research Abstract

本研究は酸化ストレス応答を制御する転写因子Bach1の心血管疾患における役割を研究するために行われた。1) ヒト血管平滑筋細胞および内皮細胞においてBach1がヘムオキシゲナーゼ1(HO-1)の発現を制御していること、2) Bach1による転写応答、特にHO-1の発現調節が圧負荷による心肥大形成に関与していること、3) Bach1欠損はHO-1の発現を介して動脈硬化形成を抑制していること、4) Bach1が心筋梗塞後の左室リモデリングにおいて重要な役割を果たしていることが明らかとなり、Bach1が心血管疾患の病態に深く関与していることが示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (33 results)

All 2009 2008 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (24 results) Book (1 results)

  • [Journal Article] Angiotensin IIinduced osteopontin expression in vascular smooth muscle cells involves Gq/11, Ras, ERK, Src and Ets-12008

    • Author(s)
      Abe K, Nakashima H, Ishida M, Miho N, Sawano M, oe NN, Kurabayashi M, Chayama K, Yoshizumi M, Ishida T
    • Journal Title

      Hypertens Res 31

      Pages: 987-998

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of the bachl gene leads to the suppression of atherosclerosis in bachl and apolipoprotein E double knockout mice2008

    • Author(s)
      Watari Y, Yamamoto Y, Brydun A, Ishida T, Mito S, Yoshizumi M, Igarashi K, Chayama K, Ohshima T, Ozono R
    • Journal Title

      Hypertens Res 31

      Pages: 783-792

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II-induced osteopontin expression in vascular smooth muscle cells in volves Gq/ll, Ras, ERK, Src and Ets-1.2008

    • Author(s)
      Keiko Abe
    • Journal Title

      Hypertension Research 31

      Pages: 987-998

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of the bach1 gene leads to the suppression of atherosclerosis in bach1 and apolipoprotein E double knockout mice.2008

    • Author(s)
      Yuichiro Watari
    • Journal Title

      Hypertension Research 31

      Pages: 783-792

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II-induced Osteopontin Expression in Vascular Smooth Muscle Cells Involves G_q/11, Ras, ERK, Src and Ets-12008

    • Author(s)
      Keiko Abe
    • Journal Title

      Hypertension Reasearch (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of the Bach1 gene Ieads to the suppression of atherosclerosis in Bach1 and ApoE double knockout mice2008

    • Author(s)
      Yuichiro Watari
    • Journal Title

      Hypertension Reasearch (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nifedipine Interferes with Migration of Vascular Smooth Muscle Cells via Inhibition of Pyk2-Src Axis

    • Author(s)
      Soe NN, Ishida T, Ishida M, Sawano M, Abe K, Miho N, Chayama K, Kihara Y, Yoshizumi M
    • Journal Title

      J Atheroscler Thromb (In press)

    • NAID

      10025765621

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nifedipine Interferes with Migration of Vascular Smooth Muscle Cellsvia Inhibition of Pyk2-Src Axis.

    • Author(s)
      Nwe Nwe Soe
    • Journal Title

      Journal of Atherosclerosis and Thrombosis (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Increased leukocyte Rhokinase (ROCK) activity and endothelialdysfunction in cigarette smoking2009

    • Author(s)
      Hidaka T
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Usefulness of 64-slice multidetector-row computed tomographyin the simultaneous evaluation of aorticvalve area and coronary artery disease2009

    • Author(s)
      Utsunomiya H
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Low-intensity pulsed ultrasound(LIPUS)enhanced angiogenesis in a rat hindlimb ischemia model, VEGF-A expression andmobilization in HUVEC2009

    • Author(s)
      Hidaka T
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Coronary plaquestabilization by intensive statin therapydecreasing serum LDL/HDL cholesterolratio on multislice computed tomographicangiography2009

    • Author(s)
      Kitagawa T
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Role of Src and Cas in dorsal ruffling, lamellipodia and migration in vascular smoothmuscle cells2009

    • Author(s)
      Soe NN
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Evaluation of coronarycalcium and noncalcified plaquecharacteristics in patients with acutecoronary syndrome by multislice computed tomography2009

    • Author(s)
      Kitagawa T
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Lower high molecular weightadiponectin level is associated withunstable coronary plaques as detected bymulty-detector computed tomography2009

    • Author(s)
      Kunita E
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Prediction of heart failuredeath in hemodialysis patients bymyocardial washout rate of technetium99m sestamibi2009

    • Author(s)
      Tadehara F
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Nonosbstructive aorticvalve calcification and cardiovascular riskfactors as predictors of coronary arteryatherosclerosis assessed by 64-slicemultidetector-row computed tomography2009

    • Author(s)
      Ustunomiya H
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Feasibility and optimization of aortic valve planimetry using retrospective ECG-gated 64-slice multidetector-row computed tomography2009

    • Author(s)
      Utsunomiya H
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Role of Src and Its Substrates in Vascular Smooth Muscle Cell Migration.2009

    • Author(s)
      Nwe Nwe Soe
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] バトルセッションーキレーション治療による動脈硬化予防「キレート療法の根拠を検証する一鉄と酸化ストレスの血管に対する作用」2008

    • Author(s)
      石田隆史
    • Organizer
      第8回日本抗加齢医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-07
    • Related Report
      2008 Final Research Report
  • [Presentation] c-Src and Its Substrates Play A Pivotal Role in Migration of Vascular Smooth Muscle Cells2008

    • Author(s)
      Nwe Nwe Soe
    • Organizer
      Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference 2008
    • Place of Presentation
      米国 Atlanta
    • Year and Date
      2008-04-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Role of HIF-1-dependent expressionof the VLDL receptor in the progression ofatherosclerosis2008

    • Author(s)
      Abe K
    • Organizer
      第72回日本循環器学会総会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] c-Src and Its Substrates Play aPivotal Role in Migration of Vascular3mooth Muscle Cells2008

    • Author(s)
      Soe NN
    • Organizer
      日本動脈硬化学会学術集会
    • Place of Presentation
      筑波
    • Related Report
      2008 Final Research Report
  • [Presentation] c-Src and Its Substrates Play a Pivotal Role in Migration of Vascular Smooth Muscle Cells. Arterioscelrosis2008

    • Author(s)
      Soe NN
    • Organizer
      Thrombosis and Vascular Biology Annual Conference 2008
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Angiotensin II-induced osteopontin expression in vascular smooth muscle cells involves Gq/11, Ras, ERK, Src and Ets-12007

    • Author(s)
      阿部恵子
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2007-11-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] Angiotensin IIによるOsteopontinの発現にはGq/11 Src, Ras, ERKが関与する2007

    • Author(s)
      外間梨沙
    • Organizer
      第30回日本高血圧学会
    • Place of Presentation
      沖縄
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Nefedipineの血管平滑筋細胞遊走・肥大およびその細胞内シグナル伝達機構におよぼす作用2007

    • Author(s)
      澤野真理子
    • Organizer
      第30回日本高血圧学会
    • Place of Presentation
      沖縄
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Hypoxia、Induces the Expression of Very Low-Density Lipoprotein Receptor in Human Macrophages and Vascular Smooth Muscle Cells via a HIF-1-Dependent Mechanism2007

    • Author(s)
      阿部恵子
    • Organizer
      第30回日本動脈硬化学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Angiotensin II-induced Osteopontin Expression in Vascular Smooth Muscle Cells involves Gq/11, Ras, ERK, Src, Ets-1 and c-Fos2007

    • Author(s)
      Abe K
    • Organizer
      Scientific Sessions of American Heart Association
    • Place of Presentation
      Orlando, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Angiotensin IIによるOsteopontinの発現にはG_<q/11>, Src, Ras, ERKが関与する2007

    • Author(s)
      外間梨沙
    • Organizer
      第30回日本高血圧学会総会
    • Place of Presentation
      沖縄
    • Related Report
      2008 Final Research Report
  • [Presentation] Nifedipineの血管平滑筋細胞遊走・肥大およびその細胞内シグナル伝達機構におよぼす作用2007

    • Author(s)
      澤野真理子
    • Organizer
      第30回日本高血圧学会総会
    • Place of Presentation
      沖縄
    • Related Report
      2008 Final Research Report
  • [Presentation] Hypoxia Induces theExpression of Very Low-DensityLipoprotein Receptor in HumanMacrophages and Vascular Smooth MuscleCells via a HIF-1 Dependent Mechanism2007

    • Author(s)
      Keiko Abe
    • Organizer
      日本動脈硬化学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Book] 「β遮断薬の心筋に対する作用」β遮断薬のすべて 第3版(荻原俊男、築山久一郎、松崎益徳、島田和幸編)2009

    • Author(s)
      石田隆史、木原康樹
    • Publisher
      先端医学社
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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