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Preventive studies on lifestyle-related genetic factors and development of metabolic syndrome

Research Project

Project/Area Number 19590595
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionWakayama Medical University

Principal Investigator

TAKESHITA Tatsuya  Wakayama Medical University, 医学部, 教授 (20150310)

Co-Investigator(Kenkyū-buntansha) MURE Kanae  和歌山県立医科大学, 医学部, 講師 (90268491)
NISHIO Nobuhiro  和歌山県立医科大学, 医学部, 講師 (00278631)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords肥満 / 内臓脂肪 / 遺伝子 / 生活習慣 / 飲酒 / 予防 / 高脂血症
Research Abstract

大企業男性労働者731名を対象として、アルコール感受性および肥満に関連する遺伝要因と生活環境要因との交互作用による健康度への影響を検討した。アルコール感受性に強く関連するALDH2遺伝子型以外にADH1B遺伝子型も飲酒時の顔面紅潮および飲酒頻度に有意に関連することが示唆された。またALDH2遺伝子型と飲酒の交互作用により血清コレステロール値が影響を受けることが示唆された。さらに、内臓脂肪面積が大きく、β3ADRが変異型の群において、運動習慣のない人は、ある人よりも肝機能指標の値が高い傾向が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (25 results)

All 2010 2009 2008 2007

All Journal Article (18 results) (of which Peer Reviewed: 16 results) Presentation (7 results)

  • [Journal Article] Association of ALDH2 Genotypes with Periodontitis Progression2010

    • Author(s)
      Nishida N, Tanaka M, Sekine S, Takeshita T, Nakayama K, Morimoto K, Shizukuishi S
    • Journal Title

      J Dental Res 89

      Pages: 138-142

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Skin sensitization study by quantitative structure-activity relationships(QSAR)2009

    • Author(s)
      Sato K, Umemura T, Tamura T, Kusaka Y, Aoyama K, Ueda A, Harada K, Minamoto K, Otsuki T, Yamashita K, Takeshita T, Shibata E, Dobashi K, Kameo S, Miyagawa M, Kaniwa M, Endo Y, Yuta K
    • Journal Title

      AATEX 14巻

      Pages: 940-946

    • NAID

      10026777817

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Paradoxical increases in serum levels of highly chlorinated PCBs in aged women in clear contrast to robust decreases in dietary intakes from 1980 to 2003 in Japan2009

    • Author(s)
      Koizumi A, Harada KH, Eslami B, Fujimine Y, Hachiya N, Hirosawa I, Inoue K, Inoue S, Koda S, Kusaka Y, Murata K, Omae K, Saito N, Shimbo S, Takenaka K, Takeshita T, Todoriki H, Wada Y, Watanabe T, Ikeda M
    • Journal Title

      Environ Health Prev Med 14巻

      Pages: 235-246

    • NAID

      10026959024

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effects of etodolac, a selective cyclooxygenase-2 inhibitor, on cancer development in extensive metaplastic gastritis, a Helicobacter pylori-negative precancerous lesion2009

    • Author(s)
      Yanaoka K, Oka M, Yoshimura N, Deguchi H, Mukoubayashi C, Enomoto S, Maekita T, Inoue I, Ueda K, Utsunomiya H, Iguchi M, Tamai H, Fujishiro M, Nakamura Y, Tsukamoto T, Inada K, Takeshita T, Ichinose M
    • Journal Title

      Int J Cancer 126巻

      Pages: 1467-1473

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Eradication of Helicobacter pylori prevents cancer development in subjects with mild gastric atrophy identified by serum pepsinogen levels2009

    • Author(s)
      Yanaoka K, Oka M, Ohata H, Yoshimura N, Deguchi H, Mukoubayashi C, Enomoto S, Inoue I, Iguchi M, Maekita T, Ueda K, Utsunomiya H, Tamai H, Fujishiro M, Iwane M, Takeshita T, Mohara O, Ichinose M
    • Journal Title

      Int J Cancer 125巻

      Pages: 2697-2703

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Smoking prevalence among dentists in Hyogo Japan 20032009

    • Author(s)
      Nishio N, Kouda K, Nishio J, Nakamura H, Sonoda Y, Takeshita T
    • Journal Title

      Ind Health 47巻

      Pages: 431-435

    • NAID

      130004483395

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高齢者におけるメンタルストレスへの反応性と運動習慣との関連性2009

    • Author(s)
      池田敬子、羽野卓三、本山貢、牟礼佳苗、竹下達也
    • Journal Title

      日本循環器病予防学会誌 44巻

      Pages: 141-151

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小中学生の心の健康と生活習慣・家庭環境2008

    • Author(s)
      松浦英夫、竹下達也
    • Journal Title

      学校保健研究 49巻

      Pages: 417-424

    • NAID

      40015885894

    • Related Report
      2008 Final Research Report
  • [Journal Article] 適正飲酒とは?節度ある適度な飲酒とは、どのくらいですか?2008

    • Author(s)
      竹下達也
    • Journal Title

      肥満と糖尿病 7巻

      Pages: 525-526

    • Related Report
      2008 Final Research Report
  • [Journal Article] Risk of gastric cancer in asymptomatic, middle-aged Japanese subjects based on serum pepsinogen and Helicobacter pylori antibody levels2008

    • Author(s)
      Yanaoka K, Oka M, Yoshimura N, Mukoubayashi C, Enomoto S, Iguchi M, Magari H, Utsunomiya H, Tamai H, Arii K, Yamamichi N, Fujishiro M, Takeshita T, Mohara O, Ichinose M
    • Journal Title

      Int J Cancer 123巻

      Pages: 917-926

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cancer high-risk subjects identified by serum pepsinogen tests : outcomes after 10-year follow-up in asymptomatic middle-aged males2008

    • Author(s)
      Yanaoka K, Oka M, Mukoubayashi C, Yoshimura N, Enomoto S, Iguchi M, Magari H, Utsunomiya H, Tamai H, Arii K, Ohata H, Fujishiro M, Takeshita T, Mohara O, Ichinose M
    • Journal Title

      Cancer Epidemiol Biomarkers Prev 17巻

      Pages: 838-845

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two Routes for Pollen Entering Indoors ; Ventilation and Clothes2008

    • Author(s)
      Takahashi Y, Takano K, Suzuki M, Nagai S, Yokosuka M, Takeshita T, Saito A, Yasueda H, Enomoto T
    • Journal Title

      J Invest Allergol Clin Immunol 18巻

      Pages: 382-388

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk of gastric cancer in asymptomatic, middle-aged Japanese subjects based on serum pepsinogen and Helicobacter pylori antibody levels2008

    • Author(s)
      Yanaoka K
    • Journal Title

      Int J Cancer 123

      Pages: 917-926

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小中学生の心の健康と生活習慣・家庭環境2008

    • Author(s)
      松浦英夫
    • Journal Title

      学校保健研究 49

      Pages: 417-424

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer high-risk subjects identified by serum pepsinogen tests: outcomes after 10-year follow-up in asymptomatic middle-aged males2008

    • Author(s)
      Yanaoka K
    • Journal Title

      Cancer Epidemiol Biomarkers Prev 17

      Pages: 838-845

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 柿酢飲用による血中抗酸化能および尿中イソプロスタンレベルの変化2007

    • Author(s)
      牟礼佳苗、竹下達也、森岡郁晴、有田幹雄
    • Journal Title

      日本衛生学雑誌 62巻

      Pages: 32-38

    • NAID

      10018539441

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 看護師の深夜勤務前後の自覚症状に関連する諸要因2007

    • Author(s)
      谷口明美、牟礼佳苗、竹下達也
    • Journal Title

      和歌山医学 58巻

      Pages: 60-68

    • NAID

      40015546948

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 虚血性心疾患患者の経時的QOL変化に関連する要因2007

    • Author(s)
      畑野富実、竹下達也、有田幹雄、山中順子
    • Journal Title

      和歌山医学 58巻

      Pages: 126-132

    • NAID

      40015650813

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 職域男性におけるALDH 2遺伝子多型別の飲酒量と血清脂質との関連性についての解析2008

    • Author(s)
      前田 真也
    • Organizer
      第81回日本産業衛生学会
    • Place of Presentation
      札幌
    • Year and Date
      2008-06-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 職域男性におけるALDH2遺伝子多型別の飲酒量と血清脂質との関連性についての解析2008

    • Author(s)
      前田真也、牟礼佳苗、竹下達也、麦谷耕一、 大畑博、岩根幹能、木下藤寿、茂原治
    • Organizer
      第81回日本産業衛生学会
    • Place of Presentation
      札幌市
    • Related Report
      2008 Final Research Report
  • [Presentation] リコペンによるミスマッチ修復異常大腸癌由来細胞内の自然発生突然変異抑制効果について2008

    • Author(s)
      牟礼佳苗、竹下達也
    • Organizer
      第78回日本衛生学会総会
    • Place of Presentation
      熊本市
    • Related Report
      2008 Final Research Report
  • [Presentation] 健診受診者におけるALDH2遺伝子多型と高感度CRPの関連性の解析2007

    • Author(s)
      前田眞也
    • Organizer
      日本産業衛生学会
    • Place of Presentation
      大阪市
    • Year and Date
      2007-04-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 運動の血中抗酸化能および循環機能に及ぼす影響2007

    • Author(s)
      有田幹雄、高橋直子、淡路水須、岩田麻衣子、古家彩美、牟礼佳苗、中村千種
    • Organizer
      第18回日本臨床スポーツ医学会学術集会
    • Place of Presentation
      別府市
    • Related Report
      2008 Final Research Report
  • [Presentation] トマト由来リコペンがミスマッチ修復関連遺伝子発現に与える影響について2007

    • Author(s)
      牟礼佳苗、竹下達也
    • Organizer
      第14回日本がん予防学会・第8回日本がん分子疫学研究会・第30回日本がん疫学研究会合同大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 健診受診者におけるALDH2遺伝子多型と高感度CRPの関連性の解析2007

    • Author(s)
      前田真也、牟礼佳苗、西尾信宏、竹下達也、麦谷耕一、大畑博、岩根幹能、木下藤寿、茂原治
    • Organizer
      第80回日本産業衛生学会
    • Place of Presentation
      大阪市
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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