A study of Infection prevention from a new viewpoint responsible for untreated HIV patients and their cognition

• Project/Area Number: 19590618
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: 独立行政法人国立病院機構(大阪医療センター臨床研究部)
• Principal Investigator: MAKIE Toshio 独立行政法人国立病院機構(大阪医療センター臨床研究部), 大阪医療センター臨床研究センター, 研究員 (80435891)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Tsuyoshi 長崎大学, 環境科学部, 教授 (80039586)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: HIV感染症 / 未治療 / CD4リンパ球 / 季節性ストレス / 免疫能 / CD4予測 / CD4陽性Tリンパ球 / 患者の至適環境 / 予測可能性 / 治療導入 / 抗レトロウイルス療法(ART) / 細胞性免疫能力 / 環境条件 / 至適環境

Research Abstract

We examined three assignments responsible for HIV patients before medication introduction ; 1) seasonal variation in CD4+ cell counts, 2) estimating CD4+ cell counts of an individual using population historical data, and 3) a feature in Japanese patients before medication introduction. The results indicated as follows ; 1) HIV patient's CD4+ cell counts decreases in early summer and increases in autumn in Japan, 2) our new method has potential that the relative coefficient between the predicted and actual CD4-counts keeps above 0.8 even in 12 month intervals, and 3) Japanese HIV patients have a feature of either the slow first hospital visit or the fast progression.

Research Products

• [Journal Article] Problems in three Japanese drug users with Human Immunodeficienc Virus infection (2008)
  • Author(s): Kuwahara T, Nakakura Y, Oda S, Mori M, Uehara T, Yoshino M, Sasakawa A, Yajima K, Umemoto A, Takada K, Makie T, Yoshihiko Yamamoto
  • Journal Title: J Med Invest 55 Pages: 156-160
  • Peer Reviewed
• [Journal Article] Burden on AISD-specialist Hospitals in Japan, Besed on the Number of Patients taking Anti-HIV Drugs (2008)
  • Author(s): Kuwahara T, Makie T, Yamamoto Y, Yoshio M, Yagura H, Sano T, Kojima K, Higasa S, Sirasaka T
  • Journal Title: Pharm Regul Sci 39(7) Pages: 421-6
  • Peer Reviewed
• [Journal Article] Liposomal amphotericin B for a case of intractable cryptococcal meningoencephalitis and immune reconstitution syndrome (2008)
  • Author(s): Sasakawa A, Yamamoto Y, Yajima K, Sakai M, Uehira T, Shirasaka T, Makie T
  • Journal Title: J Med Invest 55(3-4) Pages: 292-6
  • NAID: 130004465156
  • Peer Reviewed
• [Journal Article] Liposomal amphotericin B for a case of intractable cryptococcal meningoencephalitis and immune reconstitution syndrome (2008)
  • Author(s): Atsushi Sasakawa, et al. (Last author として掲載)
  • Journal Title: Journal of Medical Investigation 55(3-4) Pages: 292-296
  • Peer Reviewed
• [Journal Article] Burden on AIDS-specialist Hospitals in Japan, Based on the Number of Patients Taking Anti-HIV Drugs (2008)
  • Author(s): Kuwahara T, et al. (Second author として指導)
  • Journal Title: Pharmaceutical Regulatory Science 39(7) Pages: 421-426
  • Peer Reviewed
• [Journal Article] Problems in three Japanese drug users with Human Immunodeficiency Virus infection. (2008)
  • Author(s): Kuwahara T, Makie T, Yamamoto Y, et. al.
  • Journal Title: Journal of Medical Investigation 55 Pages: 156-60
  • NAID: 130004822577
  • Peer Reviewed
• [Journal Article] Predicting Tenofovir Concentration Based on Renal Factors Determined by Routine Tests Am (2007)
  • Author(s): Makie T, Nagai S, Sasakawa A, Kawamura K, Kuwahara T
  • Journal Title: J Therapeu 14(6) Pages: 514-518
  • Peer Reviewed
• [Journal Article] Tuberculous meningitis and Syphilous Meningitis in a Patient Infected with the Human Immunodeficiency Virus (2007)
  • Author(s): Makie T., Yamamoto Y., Uehira T., Shirasaka T., Takeda M
  • Journal Title: Internal medicine 46(7) Pages: 415-8
  • Peer Reviewed
• [Journal Article] Predicting Tenofovir Concentration Based on Renal Factors Determined by Routine Tests (2007)
  • Author(s): Toshio Makie, et. al.
  • Journal Title: American Journal of Therapeutics. 14 Pages: 514-518
  • Peer Reviewed
• [Journal Article] Tuberculous meningitis and Syphilous Meningitis in a Patient Infected with the Human Immunodeficiency Virus (2007)
  • Author(s): Toshio Makie, et. al.
  • Journal Title: Internal medicine 46 Pages: 415-418
  • Peer Reviewed
• [Journal Article] Estimating CD4+ cell counts of an individual using population historical data
  • Author(s): Makie T, Ishida N, Sato S, Yamamoto Y, Nakamura T
  • Journal Title: AIDS research and treatment
  • Peer Reviewed
• [Journal Article] Monthly variation in CD4+ cell counts in HIV patients
  • Author(s): Makie T, Ishida N, Sato S, Ono A, Yamamoto Y, Nakamura T
  • Journal Title: AIDS research and treatment
  • Peer Reviewed
• [Presentation] 治療法がなかった時代における患者へのアプローチと考察 (2009)
  • Author(s): 牧江俊雄
  • Organizer: 第23回日本エイズ学会
  • Year and Date: 2009-11-26
• [Presentation] 治療法がなかった時代における患者へのアプローチと考察 (2009)
  • Author(s): 牧江俊雄
  • Organizer: 第23回日本エイズ学会学術集会・総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-11-26
• [Presentation] CD4リンパ球とウイルス量の季節変動 (2007)
  • Author(s): 牧江俊雄、矢嶋敬史郎、谷口智宏、笹川淳、富成伸次郎、渡辺大、上平朝子、山本善彦、白阪琢磨
  • Organizer: 第21回日本エイズ学会
  • Year and Date: 2007-11-28
• [Presentation] CD4リンパ球とウイルス量の季節変動 (2007)
  • Author(s): 牧江 俊雄, 他
  • Organizer: 第21回日本エイズ学会
  • Place of Presentation: 広島
  • Year and Date: 2007-11-28