Epidemiological study on insulin tolerance and metabolic syndrome

• Project/Area Number: 19590643
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Nagoya City University
• Principal Investigator: SUZUKI Sadao Nagoya City University, 大学院・医学研究科, 講師 (20226509)
• Co-Investigator(Kenkyū-buntansha): TOKUDOME Shinkan 国立健康・栄養研究所, 理事長 (00037441)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: メタボリックシンドローム / インスリン抵抗性 / 肥満 / 腹囲 / BMI / 疫学 / 糖尿病

Research Abstract

In this epidemiological study on metabolic syndrome (MS), we focused on insulin tolerance and obesity which are major cause of MS, and fatty liver which is related disease of MS.We reported that without obesity, prevalence of fatty liver increased with the number of component of MS, that insulin tolerance did not add important information on MS if we had the information on obesity, and that BMI and waist circumference were not able to distinguish the visceral obesity from the subcutaneous obesity.

Research Products

• [Journal Article] Abdominal circumference should not be a required criterion for the diagnosis of metabolic syndrome (2010)
  • Author(s): Shibata K, Suzuki S, Sato J, Ohsawa I, Goto S, Hashiguchi M, Tokudome S.
  • Journal Title: Environ Health Prev Med. (Published online)
  • NAID: 10027649759
  • Peer Reviewed
• [Journal Article] Elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease in Japanese undergoing a health checkup. (2010)
  • Author(s): Yamada T, Suzuki S, Fukatsu M, Wada T, Yoshida T, Joh T.
  • Journal Title: Acta Gastroenterol Belg. 73 Pages: 12-17
  • Peer Reviewed
• [Journal Article] Fatty liver predicts impaired fasting glucose and type 2 diabetes mellitus in Japanese undergoing a health checkup. (2010)
  • Author(s): Yamada T, Fukatsu M, Suzuki S, Wada T, Yoshida T, Joh T.
  • Journal Title: J Gastroenterol Hepatol. 25 Pages: 352-356
  • Peer Reviewed
• [Journal Article] Alcohol drinking may not be a major risk factor for fatty liver in Japanese undergoing a health checkup. (2010)
  • Author(s): Yamada T, Fukatsu M, Suzuki S, Yoshida T, Tokudome S, Joh T.
  • Journal Title: Dig Dis Sci. 55 Pages: 176-182
  • Peer Reviewed
• [Journal Article] Abdominal circumference should not be a required criterion for the diagnosis of metabolic syndrome (2010)
  • Author(s): Kiyoshi Shibata, Sadao Suzuki, Shinkan Tokudome, 他4名
  • Journal Title: Environ Health Prev Med 04 February(Online)
  • NAID: 10027649759
  • Peer Reviewed
• [Journal Article] Insulin-like Growth Factor(IGF)-I, IGF-II, IGF Binding protein-3, and Risk of Colorectal Cancer : a nested case-control Study in the JACC Study (2010)
  • Author(s): Sadao Suzuki, Shinkan Tokudome, 他9名
  • Journal Title: Asian Pac J Cancer Prev 10 Supple
  • Peer Reviewed
• [Journal Article] Insulin-like Growth Factor (IGF)-I, IGF-II, IGF Binding protein-3, and Risk of Colorectal Cancer: a nested case-control study in the JACC Study. (2009)
  • Author(s): Suzuki S, Kojima M, Tokudome S, Suzuki K, Ozasa K, Ito Y, Inaba Y, Tajima K, Nakachi K, Watanabe Y, Tamakoshi A.
  • Journal Title: Asian Pac J Cancer Prev. 10 Pages: 45-50
  • Peer Reviewed
• [Journal Article] 肥満およびメタボリックシンドローム構成要素と前立腺特異抗原(PSA)値との関連. (2009)
  • Author(s): 安藤亮介, 池上要介, 橋本良博, 河合憲康, 岡村武彦, 戸澤啓一, 鈴木貞夫, 永谷照男, 徳留信寛, 郡健二郎
  • Journal Title: 泌尿器外科 2 Pages: 997-999
  • Peer Reviewed
• [Journal Article] Japan Collaborative Cohort Study Group. Effect of physical activity on breast cancer risk: findings of the Japan collaborative cohort study. (2008)
  • Author(s): Suzuki S, Kojima M, Tokudome S, Mori M, Sakauchi F, Fujino Y, Wakai K, Lin Y, Kikuchi S, Tamakoshi K, Yatsuya H, Tamakoshi A
  • Journal Title: Cancer Epidemiol Biomarkers Prev. 17 Pages: 3396-3401
  • Peer Reviewed
• [Journal Article] Inverse relationship between obesity and serum prostatespecific antigen level in healthy Japanese men: a hospital-based cross-sectional survey, 2004-2006. (2008)
  • Author(s): Ando R, Nagaya T, Hashimoto Y, Suzuki S, Itoh Y, Umemoto Y, Ikeda N, Tozawa K, Kohri K, Tokudome S.
  • Journal Title: Urology. 3 Pages: 561-565
  • Peer Reviewed
• [Journal Article] Effect of physical activity on breast cancer risk : Findings of the Japan Collaborative Cohort Study (2008)
  • Author(s): Sadao Suzuki, Shinkan To kudome, 他10名
  • Journal Title: Cancer Epidemiol Biomarkers Prey 17 Pages: 3396-401
  • Peer Reviewed
• [Presentation] Physical activity and all-cause mortality: findings from the Japan Collaborative Cohort Study. (2010)
  • Author(s): Suzuki S, Kojima M, Tokudome S, Wakai K, Kondo T, Tamakoshi K, Tamakoshi A.
  • Organizer: The Joint Scientific Meeting of IEA Western Pacific Region and 20th Japan Epidemiological Association
  • Place of Presentation: Koshigaya, Japan
• [Presentation] Effect of change in obesity indices on the change in components of metabolic syndrome. (2010)
  • Author(s): Hosono A, Suzuki S, Yamada T, Imaeda N, Shibata K, Goto C, Hattori N, Ando R, Fukatsu M, Tokudome S.
  • Organizer: The Joint Scientific Meeting of IEA Western Pacific Region and 20th Japan Epidemiological Association
  • Place of Presentation: Koshigaya, Japan
• [Presentation] Can the examination of the ocular fundus be a predictor of chronic kidney disease? (2010)
  • Author(s): Shibata K, Suzuki S, Yasuda Y, Hashiguchi M, Sato J, Goto S, Ohsawa I, Yano T.
  • Organizer: The Joint Scientific Meeting of IEA Western Pacific Region and 20th Japan Epidemiological Association
  • Place of Presentation: Koshigaya, Japan
• [Presentation] Physical activity and all-cause mortality : findings from the Japan Collaborative Cohort Study (2010)
  • Author(s): Sadao Suzuki, Shinkan Tokudome, 他4名
  • Organizer: 国際疫学会西太平洋地域学術会議 兼 第20回日本疫学会学術総会
  • Place of Presentation: 越谷市
• [Presentation] Effect of change in obesity indices on the change in components of metabolic syndrome (2010)
  • Author(s): Akihiro Hosono, Sadao Suzuki, Shinkan Tokudome, 他7名
  • Organizer: 国際疫学会西太平洋地域学術会議 兼 第20回日本疫学会学術総会
  • Place of Presentation: 越谷市
• [Presentation] 健康集団における疾病予防に対する意識調査～疾病予防の推進にあたって～ (2009)
  • Author(s): 百瀬祐紀, 小嶋雅代, 上村義季, 塩崎美波, 鈴木奈々, 鈴木貞夫, 永谷照男
  • Organizer: 第55回東海公衆衛生学会学術大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-07-25
• [Presentation] 健康日本人男性において, 肥満と前立腺特異抗原(PSA)値の間に認められる負の関連. (2009)
  • Author(s): 安藤亮介, 橋本良博, 戸澤啓一, 鈴木貞夫, 永谷照男, 徳留信寛, 郡健二郎
  • Organizer: 第153回名古屋市立大学医学会例会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-06-16
• [Presentation] Obesity, metabolic syndrome components and risk of kidney stones in Japanese. (2009)
  • Author(s): Ando R, Suzuki S, Yamada T, Kobayashi T Okada A, Itoh T, Yasui1 T, Tozawa K, Tokudome S, Kohri K.
  • Organizer: The 6th eULIS Symposium (13th European Symposium on Urolithiasis)
  • Place of Presentation: Lake of Como/Lecco, Italy
• [Presentation] "耳鳴り"は頸動脈IMT肥厚を予見する臨床所見か? (2009)
  • Author(s): 深津満, 山田珠樹, 石田正人, 恒川純, 吉田貴, 米山明彦, 岩波有美, 小磯一枝, 入江恵子, 大村真弘, 鈴木貞夫
  • Organizer: 第50回日本脈管学会総会
  • Place of Presentation: 東京
• [Presentation] 体格と身体活動の乳がんに対するリスク-JACC Studyの知見より. (2009)
  • Author(s): 鈴木貞夫, 小嶋雅代, 徳留信寛, 森満, 坂内文男, 藤野善久, 若井建志, 玉腰浩司, 八谷寛, 林櫻松, 菊地正悟, 玉腰暁子
  • Organizer: がん予防大会2009
  • Place of Presentation: 名古屋市
• [Presentation] PPAR-r遺伝子多型に着目した食事指導によるテーラーメイド前立腺がん予防法の開発. (2009)
  • Author(s): 安藤亮介, 橋本良博, 鈴木貞夫, 永谷照男, 郡健二郎, 徳留信寛
  • Organizer: 第19回日本疫学会学術総会
  • Place of Presentation: 金沢市
• [Presentation] 腹囲はメタボリックシンドローム診断の必須項目にすべきではない. (2009)
  • Author(s): 柴田清, 鈴木貞夫, 佐藤寿一, 入谷勇夫, 後藤慎一, 橋口勝, 徳留信寛
  • Organizer: 第19回日本疫学会学術総会
  • Place of Presentation: 金沢市
• [Presentation] メタボリックシンドローム診断に対するインスリン抵抗性測定の意義. (2009)
  • Author(s): 鈴木貞夫, 服部奈美, 安藤亮介, 柴田清, 今枝奈保美, 後藤千穂, 山田珠樹, 深津満, 徳留信寛
  • Organizer: 第19回日本疫学会学術総会
  • Place of Presentation: 金沢市
• [Presentation] 体格指標と腹囲により判定される肥満者の特性. (2009)
  • Author(s): 細野晃弘, 鈴木貞夫, 服部奈美, 安藤亮介, 柴田清, 今枝奈保美, 後藤千穂, 山田珠樹, 深津満, 徳留信寛
  • Organizer: 第19回日本疫学会学術総会
  • Place of Presentation: 金沢市
• [Presentation] メタボリックシンドローム診断に対するインスリン抵抗性測定の意義 (2009)
  • Author(s): 鈴木貞夫, 徳留信寛, ほか8名
  • Organizer: 日本疫学会
  • Place of Presentation: 金沢市
• [Presentation] 体格指標と腹囲により判定される肥満者の特性 (2009)
  • Author(s): 細野晃弘, 鈴木貞夫, 徳留信寛, ほか7名
  • Organizer: 日本疫学会
  • Place of Presentation: 金沢市
• [Presentation] 体格が全がん罹患に及ぼす影響-喫煙との関連について-. (2008)
  • Author(s): 鈴木貞夫, 徳留信寛, 小嶋雅代, 岩井建志, 近藤高明, 玉腰浩司, 八谷寛, 玉腰暁子
  • Organizer: がん予防大会
  • Place of Presentation: 福岡市
• [Presentation] BMIと体重変化が全がん罹患に及ぼす影響-日本人大規模コホートによる検討-. (2008)
  • Author(s): 鈴木貞夫, 徳留信寛, 小嶋雅代, 若井建志, 近藤高明, 玉腰浩司, 八谷寛, 玉腰暁子
  • Organizer: 第18回日本疫学会学術総会
  • Place of Presentation: 東京都
• [Presentation] 肥満およびメタボリックシンドローム構成要素と前立腺特異抗原値(PSA値)との関連. (2007)
  • Author(s): 安藤亮介, 鈴木貞夫, 永谷照男, 橋本良博, 戸澤啓一, 郡健二郎, 徳留信寛
  • Organizer: 第53回東海公衆衛生学会学術大会
  • Place of Presentation: 津市
  • Year and Date: 2007-07-28