The New Strategies on Controls of Infection and Oxidative Stress for Prevention and Treatment of Pulmonary Diseases in the Elderly
| Project/Area Number |
19590690
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
NAKAYAMA Katsutoshi Jikei University School of Medicine, 医学部, 准教授 (40321989)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 酸化ストレス / ウイルス感染 / 慢性閉塞性肺疾患 / ピタバスタチン / カルボシステイン / ランソプラゾール / ライノウイルス / プロトンポンプ阻害薬 / 急性増悪 / スタチン / ICAM-1 |
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| Research Abstract |
慢性閉塞性肺疾患(COPD)などの高齢者呼吸器疾患は, 酸化ストレスやウイルス感染が増悪の要因となる。我々は、気道での酸化ストレスやウイルス誘導性炎症の新たな制御分子確立を検討した。その結果、(1)脂質異常症治療薬ピタバスタチンによる培養気道上皮での抗ライノウイルス効果、(2)喀痰調整薬カルボシステインによる培養気道上皮での抗酸化ストレス効果、(3)プロトンポンプ阻害薬ランソプラゾールによるCOPD患者の急性増悪抑制効果を明らかにした。これ等の成果は国際学会や科学雑誌に発表あるいは掲載予定となった。
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Report
(3 results)
Research Products
(56 results)
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[Journal Article] Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease2008
Author(s)
Nakao I, Kanaji S, Ohta S, Matsushita H, Arima K, Yuyama N, Yamaya M, Nakayama K, Kubo H, Watanabe M, Sagara H, Sugiyama K, Tanaka H, Toda S, Hayashi H, Inoue H, Hoshino T, Nakajima A, Inoue M, Suzuki K, Aizawa H, Okinami S, Nagai H, Hasegawa M, Fukuda T, Green ED, Izuhara K.
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Journal Title
J Immnol 180
Pages: 6262-9
Related Report
Peer Reviewed
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[Journal Article] A pilot study of banxia houpu tang, a traditional Chinese medicine, for reducing pneumoni risk in older adults with dementia2007
Author(s)
Iwasaki K, Kato S, Manma Y, Niu K, Ohrui T, Okitsu R, Higuchi S, Ozaki S, Kaneko N, Seki T, Nakayama K, Furukawa K, Fujii M, Arai H.
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Journal Title
J Am Geriatr Soc 55
Pages: 2035-2040
Related Report
Peer Reviewed
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[Journal Article] Hochu-ekki-to inhibits rhinovirus infection in human tracheal epithelial cells2007
Author(s)
Yamaya M, Sasaki T, Yasuda H, Inoue D, Suzuki T, Asada M, Yoshida M, Seki T, Iwasaki K, Nishimura H, Nakayama K.
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Journal Title
Br J Pharmacol 150
Pages: 702-710
Related Report
Peer Reviewed
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[Presentation] An inhibitor of HMG-CoA reductase, pitavastatin, inhibits rhinovirus infection in human tracheal epithelial cells2008
Author(s)
Nakayama K, Asamura T, Sasaki T, Yoshida M, Yasuda H, Asada M, Ohrui T, Kuwano K, Yamaya M
Organizer
American Thoracic Society 2008 International Conference
Place of Presentation
Toronto
Related Report
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[Presentation] Carbocisteine, a mucolytic drug, induces phosphorylation of Akt, inhibits activation of caspase, and prevents apoptosis induced by oxidative stress in human tracheal epithelial cells2008
Author(s)
Yoshida M, Nakayama K, Yasuda H, Asada M, Asamura T, Sasaki T, Yamanda S, Ohrui T, Kuwano K, Yamaya M.
Organizer
American Thoracic Society 2008 International Conference
Place of Presentation
Toronto
Related Report
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