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Elucidation of the roles of an oncogene BCL6 in the adaptation response to hypoxia and its application to the therapy for esophageal cancer

Research Project

Project/Area Number 19590707
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionHokkaido University

Principal Investigator

SHIMIZU Yuichi  Hokkaido University, 北海道大学病院, 講師 (90333608)

Co-Investigator(Kenkyū-buntansha) 小林 正伸  北海道医療大学, 教授 (80241321)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords低酸素適応応答 / 低栄養環境 / 癌遺伝子 / BCL6 / 増殖 / 抗癌剤耐性 / 膵癌 / 低酸素 / 低グルコース / 抗癌剤感受性 / 低栄養 / 増殖抑制 / アポトーシス
Research Abstract

DNAマイクロアレイ法を用いた網羅的解析とRT-PCR法により、BCL6が低酸素・低グルコース条件下で発現亢進することが確認された.低グルコース環境下で固形癌細胞に発現誘導されるBCL-6蛋白が、固形癌細胞の増殖を促進し、抗癌剤に対する耐性を誘導している可能性を示唆する

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (10 results)

All 2009 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (2 results)

  • [Journal Article] Long-term outcome after endoscopic resection inpatients with hypopharyngeal carcinoma invading the subepithelium : a case series2009

    • Author(s)
      Simizu Y, Yoshida M, Kato M, Ono SNakagawa M, Homma A, Oridate N, Asaka M.
    • Journal Title

      Endoscopy

      Pages: 374-376

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic diagnosis of early squamous neoplasia of the esophagus with iodine attaining high grade intra-epithelial neoplasia turns pink within a few minutes2008

    • Author(s)
      Simizu Y, Omori T, Yokokawa A, Yoshida T, Hirota J, Ono Y, Yamamaoto J, Kato M, Asaka M.
    • Journal Title

      J Gastroentero 23(4)

      Pages: 546-550

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 早期食道癌存在診断・質的診断の進歩2008

    • Author(s)
      清水勇一, 他
    • Journal Title

      胃と腸 43

      Pages: 1422-1433

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] All-trans retinoic acid enhances murine dendritic cell migration to draining lymph nodes via the balance of matrix metalloproteinases and their inhibitors2007

    • Author(s)
      Darmanin S, Chen J, Zhao S, Cui H, Shirkoohi R, Kubo N, Kuge Y, Tamaki N, Nakagawa K, Hamada J, Moriuti T, Kobayashi M.
    • Journal Title

      J of Immunol 179

      Pages: 4616-4625

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic up-regulation of Hexokinase 2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose-deprivation and hypoxia2007

    • Author(s)
      Natsuizaka M, Ozasa M, Darmanin S, Miyamoto M, Kondo S, Kamada S, Shindoh M, Higashino F, Suhara W, Koide H, Aita K, Nakagawa K, Kondo T, Asaka M, Okada F, Kobayashi M.
    • Journal Title

      Exp. Cell Res. 313

      Pages: 3337-48

    • NAID

      120000971111

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced expression of asparagine synthetase under glucose-deprived conditions protects pancreatic cancer cells from apoptosis induced by glucose deprivation and cisplatin2007

    • Author(s)
      Cui H, Darmanin S, Natsuisaka M, Kondo T, Asaka M, Shindoh M, Higashino F, Hamuro J, Okada F, Kobayashi M, Nakagawa K, Koide H, Kobayashi M
    • Journal Title

      Cancer Res. 67

      Pages: 3346-3355

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production2007

    • Author(s)
      Iuchi Y, Okada F, Onuma K, Onoda T, Asao H, Kobayashi M, Fujii J.
    • Journal Title

      Biochem J. 402

      Pages: 219-27

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist2007

    • Author(s)
      Miseki T, Kawakami H, Natsuizaka M, Darmanin S, Cui H-Y, Chen J, Fu Q, Okada F, Shindo M, Higashino F, Asaka M, Hamuro J, and Kobayashi M
    • Journal Title

      Cancer Gene Ther. 14

      Pages: 39-44

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Histological results of EMR for esophageal lesions diagnosed as high-grade intraepithelial squamous neoplasia by endoscopic biopsy2008

    • Author(s)
      Shimizu Y, Yoshida T, Kato M. Asaka M.
    • Organizer
      International Society for Esophageal Disease
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2008-09-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Histological results of endoscopic mucosal resection for esophageal lesions diagnosed as high-grade intraepithelial squamous neoplasia by endoscopic biopsy2008

    • Author(s)
      Shimizu Y, et.al.
    • Organizer
      The 11^<th> World Congress of the International Society for Disease of the Esophagus
    • Place of Presentation
      Budapest, Hungry
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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