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The structure-activity relationship of prodefensin is investigated for a novel therapy of inflammatory bowel disease

Research Project

Project/Area Number 19590708
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionAsahikawa Medical College

Principal Investigator

TANABE Hiroki  Asahikawa Medical College, 医学部, 助教 (50396363)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords消化器学 / 自然免疫 / Paneth細胞 / DSS腸炎 / defensin / クローン病
Research Abstract

ヒト消化管における抗菌ペプチドに依存する自然免疫機能の感染防御機構を解明し, 炎症性腸疾患の消化管粘膜上皮における自然免疫の関与を検討してきた. ディフェンシンの分子異常と機能異常を検討することによって, 炎症性腸疾患の病因・病態における自然免疫機構異常の関与を解明した. さらに, 内因性抗菌ペプチドをターゲットとする新たな炎症制御の可能性を検討し, 炎症性腸疾患に対する特異的な新規治療法の開発をめざす.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (19 results)

All 2009 2008 2007 Other

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] Functional Role of Metaplastic Paneth Cell Defensins in Helicobacter pylori- Infected Stomach2008

    • Author(s)
      Hiroki Tanabe, Tomonobu Sato, Jiro Watari, Atsuo Maemoto, Mikihiko Fijiya, Toru Kono, Toshifumi Ashida, Tokiyoshi Ayabe, Yutaka Kohgo
    • Journal Title

      Helicobacter 13

      Pages: 370-379

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional Role of Metaplastic Paneth Cell Defensins in Helicobacter pylori-Infected Stomach2008

    • Author(s)
      Hiroki Tanabe
    • Journal Title

      Helicobacter 13

      Pages: 370-379

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion2007

    • Author(s)
      Tanabe H, Ayabe T, Maemoto A, Ishikawa C, Inaba Y, Sato R, Moriichi K, Okamoto K, Watari J, Kono T, Ashida T, Kohgo Y.
    • Journal Title

      Biochem Biophys Res Commun. 358

      Pages: 349-55

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] クローン病におけるPaneth細胞由来抗菌ペプチドの産生異常2007

    • Author(s)
      田邊裕貴, 前本篤男, 綾部時芳, 河野透, 蘆田知史, 高後裕
    • Journal Title

      分子消化器病 4

      Pages: 110-115

    • Related Report
      2008 Final Research Report
  • [Journal Article] Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion.2007

    • Author(s)
      Hiroki Tanabe
    • Journal Title

      Biochem Biophys Res Commun 358

      Pages: 349-355

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] クローン病におけるPaneth細胞由来抗菌ペプチドの産生異常2007

    • Author(s)
      田邊裕貴
    • Journal Title

      分子消化器病 4

      Pages: 110-115

    • Related Report
      2007 Annual Research Report
  • [Presentation] Precursor processing of human defensin-5 is essential to the physiological functions in vivo and in vitro2009

    • Author(s)
      Hiroki Tanabe
    • Organizer
      2009 International symposium on Regulatory Peptide
    • Place of Presentation
      Santa Barbara, CA
    • Year and Date
      2009-01-27
    • Related Report
      2008 Final Research Report
  • [Presentation] Precursor processing of human defensin-5 is essential to the physiologic al functions in vivo and in vitro2009

    • Author(s)
      Hiroki Tanabe
    • Organizer
      International Symposium on Regulatory Peptide
    • Place of Presentation
      Santa Barbara, CA
    • Year and Date
      2009-01-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 必須アミノ酸L-isoleucineはβ-defensin 2発現量を増加させる2008

    • Author(s)
      金野陽高, 田邊裕貴, 前本篤男, 蘆田知史, 高後裕
    • Organizer
      第50回日本消化器病学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-02
    • Related Report
      2008 Final Research Report
  • [Presentation] 必須アミノ酸L-isoleuchleはβ-defensin 2発現量を増加させる2008

    • Author(s)
      金野陽高
    • Organizer
      第50回日本消化器病学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 腸管粘膜における抗菌ペプチドの役割2008

    • Author(s)
      田邊裕貴, 藤谷幹浩, 高後裕
    • Organizer
      平成20年度北海道腸内細菌叢研究会
    • Place of Presentation
      札幌
    • Year and Date
      2008-09-19
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] ヒト大腸癌におけるα-defensin発現はMAPK阻害剤にて抑制される2008

    • Author(s)
      田邊裕貴, Zaky Amen, 石川千里, 上野伸展, 金野陽高, 稲場勇平, 伊藤貴博, 盛一健太郎, 岡本耕太郎, 藤谷幹浩, 高後裕
    • Organizer
      第95回北海道癌談話会
    • Place of Presentation
      旭川
    • Year and Date
      2008-09-06
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] パネト細胞α-defensinと腸内自然免疫クローン病との関わりを含めて2008

    • Author(s)
      綾部時芳, 深谷梨恵, 坂井直樹, 前本篤男, 蘆田知史, 河野透, 田邊裕貴, 高後裕
    • Organizer
      第45回補体シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2008-07-11
    • Related Report
      2008 Final Research Report
  • [Presentation] バネト細胞α-definsinと腸内自然免疫クローン病との関わりを含めて2008

    • Author(s)
      綾部時芳
    • Organizer
      第45回補体シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2008-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Human enteric defensin induces acquired immunity through activation processing2007

    • Author(s)
      Hiroki Tanabe
    • Organizer
      13th International Congress of Mucosal Immunology
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Human enteric defensin induces acquired immunity through activation processing2007

    • Author(s)
      Tanabe H
    • Organizer
      13^<th> International Congress of Mucosal Immunology
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-07-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Disruption of innate immunity in Crohn's disease2007

    • Author(s)
      Maemoto A, Tanabe H, Inaba Y, Ito T, Ashida T, Ayabe T, Kohgo Y.
    • Organizer
      13^<th> International Congress of Mucosal Immunology
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-07-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Down-regulation of Paneth cell a-defensin expression and function in patients with Crohn's disease2007

    • Author(s)
      Maemoto A, Ayabe T, Tanabe H, Inaba Y, Ashida T, Fukaya R, Sakai N, Kono T, Kohgo Y.
    • Organizer
      American Gastroenterological Association
    • Place of Presentation
      Washington DC
    • Year and Date
      2007-05-22
    • Related Report
      2008 Final Research Report
  • [Remarks] ホームページ等本研究の一部は旭川医科大学学術成果リポジトリ(AMCoR)から検索が可能である.

    • URL

      http://amcor.asahikawa-med.ac.jp/modules/xoonips/

    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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