Disruption of gastric barrier function by luminal nitrosative stress : A potential chemical insult to human gastro-oesophageal junction

• Project/Area Number: 19590710
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tohoku University
• Principal Investigator: IIJIMA Katsunori Tohoku University, 病院, 助教 (60375003)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 消化器内科学 / 消化器学

Research Abstract

食道・胃接合部で発生する癌は、欧米を中心に急速に増加しており、食生活の欧米化などに伴い、今後、本邦でもその増加が危惧されている。私は、これまでヒトの食道・胃接合部で限局性に発生する一酸化窒素(NO)が同部の炎症・発がんと関連しているという仮説をたて研究を進めてきた。今回のラットの動物モデルを用いた研究で、NOが食道・胃接合部の粘膜表面に傷害を及ぼすことを明らかにされ、今後、発がんとの関連に関しての検討が期待される。

Research Products

• [Journal Article] Sustained epithelial proliferation in a functionally irreversible fundic mucosa after H. pylori eradication (2009)
  • Author(s): Iijima K, et.al.
  • Journal Title: Journal of Gastroenterology 44 Pages: 47-55
  • NAID: 40017666302
  • Peer Reviewed
• [Journal Article] Serum biomarker tests in delineation between patients with gastric atrophy or healthy, normal stomach (2009)
  • Author(s): Iijima K, et.al.
  • Journal Title: World Journal of Gastroenterology 21 Pages: 853-859
  • Peer Reviewed
• [Journal Article] Barrett's esophagus is characterized by the absence of H. pylori infection and high level of serum pepsinogen I concentration in Janan (2009)
  • Author(s): Abe Y, Iijima K, et.al.
  • Journal Title: Journal of Gastroenterology and Hepatology 24 Pages: 129-134
  • Peer Reviewed
• [Journal Article] al. Disruption of gastric barrier function by luminal nitrosative stress : a potential chemical insult to the human gastro-oesophageal junction (2008)
  • Author(s): Ara N, Iijima K, Asanuma K, et.al.
  • Journal Title: Gut 57(3) Pages: 306-313
  • Peer Reviewed
• [Journal Article] Long-term outcomes of gastric mucosa-associated lymphoid tissue lymphomas after Helicobacter pylori eradication therapy (2008)
  • Author(s): Terai S, Iijima K, Kato K, et.al.
  • Journal Title: Tohoku J Exp Med 214(1) Pages: 79-87
  • NAID: 10020179582
  • Peer Reviewed
• [Journal Article] Long-term outcomes of gastric mucosa-associated lymphoid tissue lymphomas after Helicobacter pylori eradication therapy. (2008)
  • Author(s): Terai S, Iijima K, et. al.
  • Journal Title: Tohoku J Exp Med. 214 Pages: 79-87
  • NAID: 10020179582
  • Peer Reviewed
• [Journal Article] Disruption of gastric barrier function by luminal nitrosative stress: a potential chemical insult to the human gastro-oesophageal junction. (2008)
  • Author(s): Ara N, IijimaK, et. al.
  • Journal Title: Gut 57 Pages: 306-13
  • Peer Reviewed
• [Journal Article] Fe-S cluster proteins are intracellular targets for nitric oxide generated luminally at the gastro-oesophageal junction (2007)
  • Author(s): Asanuma K, Iijima K, Ara N, et.al.
  • Journal Title: Nitric Oxide 16(4) Pages: 395-402
  • Peer Reviewed
• [Journal Article] Extensive gastric atrophy : an increased risk factor for superficial esophageal squamous-cell carcinoma in Japan (2007)
  • Author(s): Iijima K, Koike T, Abe Y, et.al.
  • Journal Title: Am J Gastroenterol 102(8) Pages: 1603-1609
  • Peer Reviewed
• [Journal Article] Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation (2007)
  • Author(s): Combet E, Paterson S, Iijima K, et.al.
  • Journal Title: Gut 56(12) Pages: 1678-1684
  • Peer Reviewed
• [Journal Article] 今月のテーマ : 食道・胃接合部における一酸化窒素(NO)の発生 (2007)
  • Author(s): 飯島克則、浅沼清孝、大原秀一、下瀬川徹
  • Journal Title: 日消誌2007 104 Pages: 17-22
• [Journal Article] 硝酸塩と胃酸分泌 : 噴門部癌、非噴門部胃癌との関連 (2007)
  • Author(s): 飯島克則、浅沼清孝、小池智幸、ほか
  • Journal Title: Helicobacter Research 11 Pages: 335-339
• [Journal Article] Extensive gastric atrophy: an increased risk factor for superficial esophageal squamous cell carcinoma in Japan (2007)
  • Author(s): Iijima K, et. al.
  • Journal Title: Am J Gastroenterol 102 Pages: 1603-9
  • Peer Reviewed
• [Presentation] ラット逆流性食道炎モデルにおける外因性一酸化窒素食道暴露による影響 (2008)
  • Author(s): 飯島克則、他
  • Organizer: 第8回日本NO学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2008-05-09
• [Presentation] 食道・胃接合部と一酸化窒素 (2007)
  • Author(s): 飯島克則
  • Organizer: 第7回日本NO学会学術集会
  • Place of Presentation: 大津
  • Year and Date: 2007-05-17
• [Presentation] 食道・胃接合部で発生したNOによる周囲組織tight junctionの傷害 (2007)
  • Author(s): 荒誠之、飯島克則、ほか
  • Organizer: 第7回日本NO学会学術集会
  • Place of Presentation: 大津
  • Year and Date: 2007-05-17
• [Presentation] 食道・胃接合部と一酸化窒素 (2007)
  • Author(s): 飯島克則
  • Organizer: 日本NO学会学術集会
  • Place of Presentation: 大津
  • Year and Date: 2007-05-17