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Analysis of esophagopharyngeal reflux using 24-hr ambulatory pharyngoesophageal impedance and pH monitoring

Research Project

Project/Area Number 19590713
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionGunma University

Principal Investigator

KAWAMURA Osamu  Gunma University, 医学部, 助教 (60292596)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords胃食道咽頭逆流 / 弱酸性逆流 / 胃食道逆流症 / インピーダンス・pHモニタリング / 慢性咳嗽 / 胃食道逆流症上気道合併症 / 弱酸性咽頭内気体逆流 / 胃食道逆流 / 上気道合併症 / pHインピーダンスモニタリング / esophagopharyngeal weakly-acidic gas reflux / 慢性咳漱 / pH、インピーダンスモニタリング
Research Abstract

We studied patients with chronic cough who responded to full-dose PPI therapy, in whom 24-hr pharyngoesophageal impedance and pH monitoring was performed. Most patients with chronic cough responding to PPIs had minor acidic gas reflux and/or swallow-induced weakly acidic and/or acidic reflux in the pharynx. A direct effect of acidic mist or acidic liquid refluxing into the pharynx was suggested to be the cause of their chronic cough. In some patients, symptoms may arise indirectly from gastroesophageal reflux via a vago-vagal reflex.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2010 2009 2008 2007

All Presentation (9 results)

  • [Presentation] 非酸逆流の意義と治療戦略2010

    • Author(s)
      河村修
    • Organizer
      第6回日本消化管学会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2010-02-20
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 弱酸性 (weakly acidic) 咽頭内気体逆流と酸性・弱酸性の嚥下誘発性咽頭内逆流は、PPIに反応した慢性咳嗽患者において有意に増加していた2009

    • Author(s)
      河村修
    • Organizer
      第14回GERD研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-21
    • Related Report
      2009 Final Research Report
  • [Presentation] 弱酸性(weakly acidic)咽頭内気体逆流と酸性・弱酸性の嚥下誘発性咽頭内逆流は、PPIに反応した慢性咳嗽患者において有意に増加していた2009

    • Author(s)
      河村修
    • Organizer
      第14回GERD研究会
    • Place of Presentation
      ANAインターコンチネンタルホテル東京(東京)
    • Year and Date
      2009-11-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Weakly acidic pharyngeal gas reflux and GERD-related chronic cough -24-hr esophago-pharyngeal impedance and pH monitoring in Japanese population2008

    • Author(s)
      河村修
    • Organizer
      9th World Congress, OESO
    • Place of Presentation
      Monaco
    • Related Report
      2009 Final Research Report
  • [Presentation] Weakly acidic pharyngeal gas reflux and GERD-related chronic cough-24-hr esophago-pharyngeal impedance and pH monitoring in Japanese population2008

    • Author(s)
      河村修
    • Organizer
      9th World Congress, OESO
    • Place of Presentation
      Monaco
    • Related Report
      2008 Annual Research Report
  • [Presentation] 24時間インピーダンスpHモニタリングによるGERD関連慢性咳嗽患者の食道咽頭逆流の評価2007

    • Author(s)
      河村修
    • Organizer
      第59回日本気管食道科学会総会
    • Place of Presentation
      群馬県民会館(前橋)
    • Year and Date
      2007-11-01
    • Related Report
      2009 Final Research Report
  • [Presentation] 24時間インピーダンスpHモニタリングによるGERD関連慢性咳漱患者の食道咽頭逆流の評価2007

    • Author(s)
      河村 修
    • Organizer
      第59回日本気管食道科学会総会
    • Place of Presentation
      前橋
    • Year and Date
      2007-11-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] 24時間インピーダンスpHモニタリングによるGERD関連慢性咳嗽患者の食道咽頭逆流の評価2007

    • Author(s)
      河村修
    • Organizer
      第61回日本食道学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2007-06-21
    • Related Report
      2009 Final Research Report
  • [Presentation] 24時間インピーダンスpHモニタリングによるGERD関連慢性咳漱患者の食道咽頭逆流の評価2007

    • Author(s)
      河村 修
    • Organizer
      第61回日本食道学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2007-06-21
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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