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Development of new therapeutic strategy for gastric cancer targeting to tumor stroma

Research Project

Project/Area Number 19590726
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionHiroshima University

Principal Investigator

KITADAI Yasuhiko  Hiroshima University, 大学院・医歯薬学総合研究科, 准教授 (10304437)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords胃癌 / 腫瘍間質 / 分子標的治療 / PDGFR / VEGF-C / D / リンパ節転移 / PDGF
Research Abstract

胃癌組織においては、PDGFRの発現は間質において認められ、筋線維芽細胞、ペリサイト、リンパ管内皮細胞が主な発現細胞であった。ヌードマウス同所移植モデルを用い、PDGFRリン酸化阻害剤イマチニブの胃癌に対する治療実験を行ったところ、腫瘍間質の質的、量的変化、抗癌剤の腫瘍増殖抑制効果の増強作用が認められた。本研究により癌間質を標的とした胃癌に対する新しい治療法の可能性が示された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (27 results)

All 2008 2007

All Journal Article (13 results) (of which Peer Reviewed: 8 results) Presentation (12 results) Book (2 results)

  • [Journal Article] Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors2008

    • Author(s)
      Kuwai, T., Nakamura, T., Kim, S. J., Sasaki, T., Kitadai, Y., Langley, R. R., Fan, D., Hamilton, S. R., Fidler, I. J.
    • Journal Title

      Am. J. Pathol. 172

      Pages: 358-366

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy2008

    • Author(s)
      Kuwai, T., Nakamura, T., Sasaki, T., Kitadai, Y., Kim, J. S., Langley, R. R., Fan, D., Wang, X., Do, K. A., Kim, S. J., and Fidler, I. J.
    • Journal Title

      Clin. Exp. Metastasis 25

      Pages: 477-489

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paracrine mechanisms2008

    • Author(s)
      Kodama, M., Kitadai, Y., Tanaka, M., Kuwai, T., Tanaka, S., Oue, N., Yasui, W., Chayama, K
    • Journal Title

      Clin. Cancer Res 14

      Pages: 7205-7214

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy.2008

    • Author(s)
      Kuwai, T.
    • Journal Title

      Clin. Exp. Metastasis 25

      Pages: 477-489

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paracrine mechanisms.2008

    • Author(s)
      Kodama, M.
    • Journal Title

      Clin. Cancer Res. 14

      Pages: 7205-7214

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大腸腫瘍間質をターゲットとした分子標的治療2008

    • Author(s)
      桑井寿雄
    • Journal Title

      消化器疾患におけるTranslational Research(アークメディア)

      Pages: 146-152

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors.2008

    • Author(s)
      Kuwai, T.
    • Journal Title

      Am. J. Pathol. 172

      Pages: 358-366

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of EGFR and VEGFR phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice2007

    • Author(s)
      Sasaki, T., Kitadai, Y., Kuwai, T., Nakamura, T., Bucana, C. D., Fidler, I. J.
    • Journal Title

      Neoplasia 9

      Pages: 1066-1077

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 癌間質を標的とした消化器癌転移制御の可能性を探る2007

    • Author(s)
      北台靖彦、児玉美千世、桑井寿雄、茶山一彰
    • Journal Title

      分子消化器病 4

      Pages: 41-46

    • Related Report
      2008 Final Research Report
  • [Journal Article] PDGFRチロシンキナーゼ阻害剤による大腸癌間質反応の抑制と腫瘍増殖・転移抑制効果2007

    • Author(s)
      北台靖彦、児玉美千世、桑井寿雄、茶山一彰
    • Journal Title

      消化器科 44

      Pages: 463-467

    • Related Report
      2008 Final Research Report
  • [Journal Article] Inhibition of EGFR and VEGFR phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice.2007

    • Author(s)
      Sasaki, T.
    • Journal Title

      Neoplasia 9

      Pages: 1066-1077

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 癌間質を標的とした消化器癌転移制御の可能性を探る。2007

    • Author(s)
      北台 靖彦
    • Journal Title

      分子消化器病 4

      Pages: 41-46

    • Related Report
      2007 Annual Research Report
  • [Journal Article] PDGFRチロシンキナーゼ阻害剤による大腸癌間質反応の抑制と腫瘍増殖・転移抑制効果。2007

    • Author(s)
      北台 靖彦
    • Journal Title

      消化器科 44

      Pages: 463-467

    • Related Report
      2007 Annual Research Report
  • [Presentation] Expression of platelet-derived growth factor(PDGF)-B and PDGF-receptor is associated with lymphatic metastasis in gastric carcinoma.2008

    • Author(s)
      Kodama, M.
    • Organizer
      20^<th> Meeting of the European Association for Cancer Research
    • Place of Presentation
      Lyon, France
    • Year and Date
      2008-07-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] Inhibition of reactive stroma by platelet derived growth factor receptor tyrosine kinase inhibitor reduces growth and lymph node metastasis of human colon carcinoma2008

    • Author(s)
      Kitadai, Y., Kodama, M., Tanaka, M., Sasaki, T., Kuwai, T., Nakamura, T., Fidler, I.J.
    • Organizer
      20^<th> Meeting of the European Association for Cancer Research
    • Place of Presentation
      Lyon, France(poster presentation)
    • Year and Date
      2008-07-05
    • Related Report
      2008 Final Research Report
  • [Presentation] A potential role for vascular endothelial growth factor-D as an autocrine factor for human gastric carcinoma2008

    • Author(s)
      Tanaka, M., Kitadai, Y., Kodama, M., Shinagawa, K., Sumida, T., Kuroda, T., Tanaka, S., Chayama, K.
    • Organizer
      20^<th> Meeting of the European Association for Cancer Research
    • Place of Presentation
      Lyon, France(poster presentation)
    • Year and Date
      2008-07-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor beta is associated with lymphatic metastasis in gastric carcinoma2008

    • Author(s)
      Kodama, M., Kitadai, Y., Tanaka, M., Shinagawa, K., Sumida, T., Kuroda, T., Tanaka, S., Chayama, K.
    • Organizer
      20^<th> Meeting of the European Association for Cancer Research
    • Place of Presentation
      Lyon, France(poster presentation)
    • Year and Date
      2008-07-05
    • Related Report
      2008 Final Research Report
  • [Presentation] 大腸腫瘍間質をターゲットとした分子標的治療-ヌードマウス同所移植腫瘍モデルを用いた検討-2007

    • Author(s)
      北台靖彦、桑井寿雄、佐々木隆光、児玉美千世、田中信治、茶山一彰
    • Organizer
      第18回日本消化器癌発生学会総会、ワークショップ
    • Place of Presentation
      札幌
    • Year and Date
      2007-11-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 胃癌増殖におけるPDGF/レセプター系の発現はリンパ節転移や胃癌の組織型と関連する2007

    • Author(s)
      児玉美千世、北台靖彦、品川慶、田中美和子、炭田知宜、黒田剛、田中信治、茶山一彰
    • Organizer
      第18回日本消化器癌発生学会総会、パネルディスカッション
    • Place of Presentation
      札幌
    • Year and Date
      2007-11-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 胃癌増殖におけるPDGF/レセプター系の発現はリンパ節転移や胃癌の組織型と関連する。2007

    • Author(s)
      児玉美千世
    • Organizer
      第18回日本消化器癌発生学会総会、パネルディスカッション
    • Place of Presentation
      札幌
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 大腸腫瘍間質をターゲットとした分子標的治療 -ヌードマウス同所移植腫瘍モデルを用いた検討-。2007

    • Author(s)
      北台 靖彦
    • Organizer
      第18回日本消化器癌発生学会総会、ワークショップ
    • Place of Presentation
      札幌
    • Year and Date
      2007-08-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヌードマウス同所移植腫瘍モデルを用いた大腸癌のEGFR, VEGFR, PDGFRをターゲットとした分子標的治療の検討2007

    • Author(s)
      桑井寿雄、北台靖彦、佐々木隆光、中村透、Kim, S-J、Fidler I.J.
    • Organizer
      第16回日本がん転移学会総会、ワークショップ
    • Place of Presentation
      富山
    • Year and Date
      2007-07-09
    • Related Report
      2008 Final Research Report
  • [Presentation] 胃癌増殖においてvascular endothelial growth factor Cはオートクライン的にも作用する2007

    • Author(s)
      児玉美千世、北台靖彦、品川慶、田中美和子、炭田知宜、黒田剛、田中信治、茶山一彰
    • Organizer
      第16回日本がん転移学会総会、ワークショップ
    • Place of Presentation
      富山
    • Year and Date
      2007-07-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Targeting the Expression of Platelet-Derived Growth Factor Receptor by Reactive Stroma Inhibits Growth and Metastasis of Human Colon Carcinoma2007

    • Author(s)
      Kitadai, Y., Sasaki, T., Kuwai, T., Nakamura, T., Bucana, C.D., Chayama, K., Fidler I.J.
    • Organizer
      98th Annual Meeting of the American Association for Cancer Research, Los Angeles, CA, USA
    • Place of Presentation
      Mini Symposium
    • Year and Date
      2007-04-14
    • Related Report
      2008 Final Research Report
  • [Presentation] 大腸癌の微小血管構成細胞をターゲットとした血管新生抑制療法-ヌードマウス同所移植腫瘍モデルを用いた検討-2007

    • Author(s)
      北台靖彦、佐々木隆光、桑井寿雄、茶山一彰
    • Organizer
      第3回日本消化管学会学術集会コアシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-02-01
    • Related Report
      2008 Final Research Report
  • [Book] 消化器がん化学療法2008(分子標的治療(総論))2008

    • Author(s)
      安井弥、北台靖彦
    • Publisher
      日本メディカルセンター
    • Related Report
      2008 Final Research Report
  • [Book] 大腸腫瘍間質をターゲットとした分子標的治療2008

    • Author(s)
      桑井寿雄、北台靖彦、茶山一彰
    • Publisher
      消化器疾患におけるTranslational Research(アークメディア)
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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