Roles of prostaglandin transporters and 15-hydroxyprostaglandin dehydrogenase in the pathogenesis of gastric cancer
| Project/Area Number |
19590733
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka City University |
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Principal Investigator |
WATANABE Toshio Osaka City University, 大学院・医学研究科, 准教授 (50336773)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Yasuhiro 大阪市立大学, 大学院・医学研究科, 准教授 (40285292)
TOMINAGA Kazunari 大阪市立大学, 大学院・医学研究科, 准教授 (80336768)
TANIGAWA Tetsuya 大阪市立大学, 大学院・医学研究科, 講師 (70423879)
樋口 和秀 大阪医科大学, 第二内科, 教授 (20218697)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 癌 / プロスタグランジン / 細胞増殖 / 増殖 / 予後 |
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| Research Abstract |
We investigated role of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a catabolic enzyme for biological inactivation of prostaglandins (PG), in gastric carcinogenesis. In 35 of 71 cases of gastric adenocarcinoma, expression of 15-PGDH protein was reduced in tumor tissues. Multivariate analysis revealed reduction of 15-PGDH expression to be an independent predictor of poor survival. The proportion of Ki67-positive cells in 15-PGDH-negative adenocarcinoma was higher than that in 15-PGDH-positive adenocarcinoma. In an in vitro study, use of specific siRNA to silence 15-PGDH enhanced cell proliferation in the gastric cancer cell line AGS, which expresses 15-PGDH. These findings suggest that reduction of 15-PGDH is an independent predictor of poor survival associated with enhancement of cell proliferation in gastric adenocarcinoma.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma2010
Author(s)
Tatsuwaki H、Tanigawa T, Watanabe T, Machida H, Okazaki H, Yamagami H, Shiba M, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Muguruma K, Sawada T, Hirakawa K, Higuchi K, Arakawa T
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Journal Title
Cancer Sci Vol.101
Pages: 550-558
NAID
Related Report
Peer Reviewed
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[Presentation] 胃癌における15-hydroxyprostaglandin dehydrogenaseの発現動態とその意義2008
Author(s)
達脇大, 谷川徹也, 渡辺俊雄, 町田浩久, 岡崎博俊, 斯波將次, 富永和作, 伊倉義弘, 藤原靖弘, 押谷伸英, 六車一哉, 澤田鉄二, 平川弘聖, 樋口和秀, 荒川哲男
Organizer
第4回日本消化管学会総会学術集会
Place of Presentation
大阪
Year and Date
2008-02-07
Related Report
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[Presentation] 胃癌組織における15-Hydroxyprostaglandin dehydrogenaseの発現動態の検討2008
Author(s)
達脇大, 谷川徹也, 渡辺俊雄, 町田浩久, 岡崎博俊, 斯波將次, 富永和作, 藤原靖弘, 押谷伸英, 六車一哉, 澤田鉄二, 平川弘聖, 樋口和秀, 荒川哲男
Organizer
第94回日本消化器病学会総会
Place of Presentation
福岡
Related Report
