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Role of innate immunity in the pathogenesis of autoimmune pancreatitis and analysis of its autoantigens

Research Project

Project/Area Number 19590762
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKansai Medical University (2008)
Kyoto University (2007)

Principal Investigator

NISHIO Akiyoshi  Kansai Medical University, 医学部, 准教授 (50362463)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords自己免疫性膵炎 / 自然免疫 / toll-like receptor / 自己抗体 / 抗原エピトープ膵分泌性トリプシンインヒビター / 膵分泌性トリプシンインヒビター / 内科 / 免疫学 / 動物
Research Abstract

自己免疫性膵炎の病態を解明をするために、マウス膵炎モデルを解析した。各種toll-like receptorリガンドを投与し血清サイトカインの動態と膵炎の発症を検討した結果、インターロイキン10が膵炎の発症抑制に重要と考えられた。さらに、膵分泌性トリプシンインヒビター(PSTI)に対する自己抗体がPSTIのトリプシン結合部と反応してその活性を抑制し、トリプシンの活性化を促進して膵炎を増悪させる可能性を明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (28 results)

All 2010 2009 2008 2007

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (13 results)

  • [Journal Article] Analysis of humoral immune response in experimental autoimmune pancreatitis in mice2010

    • Author(s)
      Masanori Asada, Akiyoshi Nishio, Takuji Akamatsu, 11名、2番目
    • Journal Title

      Pancreas 39

      Pages: 224-231

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Atypical retroperitoneal fibrosis associated with biliary stricture : IgG4-related sclerosing disease?2009

    • Author(s)
      Mitsunobu Matsushita, Akiyoshi Nishio, Kazuichi Okazaki, 5名、4番目
    • Journal Title

      Scand J Gastroenterol 44

      Pages: 1146-1147

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of autoimmune pancreatitis2009

    • Author(s)
      Kazushige Uchida, Akiyoshi Nishio, Kazuichi Okazaki, 12名、3番目
    • Journal Title

      J Gastroenterol 44

      Pages: 726-732

    • NAID

      10025176191

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epinephrine sprayed on the papilla for prevention of post-ERCP pancreatitis2009

    • Author(s)
      Mitsunobu Matsushita, Akiyoshi Nishio, Kazuichi Okazaki, 6名、5番目
    • Journal Title

      J Gastroenterol 44

      Pages: 71-75

    • NAID

      10025173161

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human TSLP and TLR3 ligands promote differentiation of Th17 cells with a central memory phenotype under Th2-polarizing conditions2009

    • Author(s)
      Junya Tanaka, et al
    • Journal Title

      Clin Exp Allergy 39

      Pages: 89-100

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human TSLP and TLR3 ligands promote differentiation of Th17 cells with a central memory phenotype under Th2-polarizing conditions2008

    • Author(s)
      Junya Tanaka, Norihiko Watanabe, Akiyoshi Nishio, 7名、6番目
    • Journal Title

      Clin Exp Allergy 39

      Pages: 89-100

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human TSLP directly enhances expansion of CD8+ T cells2008

    • Author(s)
      Takuji Akamatsu, Norihiko Watanabe, Akiyoshi Nishio, 8名、7番目
    • Journal Title

      Clin Exp Immunol 154

      Pages: 98-106

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated Signaling2008

    • Author(s)
      Masahiro Kido, Norihiko Watanabe, Akiyoshi Nishio, 9名、7番目
    • Journal Title

      Gastroenterology 154

      Pages: 98-106

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Smad3 phosphoisoform-mediated signaling in the development of colonic cancer in IL-10-deficient mice2008

    • Author(s)
      Daisaku Hachimine, Akiyoshi Nishio, Kazuichi Okazaki, 13名、4番目
    • Journal Title

      Int J Oncol 32

      Pages: 1221-1226

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fatal autoimmune hepatitis induced by concurrent loss of naturally arising reeulatory T cells and PD-1-mediated Signaling2008

    • Author(s)
      Masahiro Kido, et al
    • Journal Title

      Gastroenterology 135

      Pages: 1333-43

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human TSLP directly enhances expansion of CD8+ T cells2008

    • Author(s)
      Takuji Akamatsu, et al
    • Journal Title

      Clin Exp Immunol 154

      Pages: 98-106

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross-primed CD8+ cytotoxic T cells induce severe Helicobacter-associated gastritis in the absence of CD4+ T cells2007

    • Author(s)
      Toshiro Fukui, Akiyoshi Nishio, Kazuichi Okazaki, 14名、2番目
    • Journal Title

      Helicobacter 12

      Pages: 486-497

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Localized cytomegalovirus reactivation after radiotherapy for high-grade gastric lymphoma2007

    • Author(s)
      Kazuyuki Saga, Toshiro Fukui, Akiyoshi Nishio, 8名、7番目
    • Journal Title

      Gastrointestinal Endoscopy 65

      Pages: 545-547

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Localized cytomegalovirus reactivation after radiotherapy for, high-grade gastric lymphoma.2007

    • Author(s)
      Kazuyuki Saga
    • Journal Title

      Gastrointestinal Endoscopy 65

      Pages: 545-7

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross-primed CD8+ cytotoxic T cells induce severe Helicobacter-associated gastritis in the absence of CD4+ T cells.2007

    • Author(s)
      Toshiro Fukui
    • Journal Title

      Helicobacter 12

      Pages: 486-97

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウスモデルを用いた自己免疫性膵炎発症における自然免疫の関与2009

    • Author(s)
      西尾彰功
    • Organizer
      第51回日本消化器病学会大会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Fetal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling2008

    • Author(s)
      Masahiro Kido
    • Organizer
      2008年度日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling2008

    • Author(s)
      Masahiro Kido, et al
    • Organizer
      2008年度日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of various toll-like receptor stimulation on the development of murine autoimmune pancreatitis2008

    • Author(s)
      Akiyoshi Nishio
    • Organizer
      109th Annual Meeting of the American Gastroenterological Association
    • Place of Presentation
      米国 サンディエゴ
    • Year and Date
      2008-05-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Development of a new mouse model of fatal autoimmune hepatitis2008

    • Author(s)
      Norihiko Watanabe
    • Organizer
      109th Annual Meeting of the American Gastroenterological Association
    • Place of Presentation
      米国 サンディエゴ
    • Year and Date
      2008-05-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of Various Toll-like Receptor Stimulation On The Development of Murine Autoimmune Pancreatitis2008

    • Author(s)
      Akiyoshi Nishio, et al
    • Organizer
      109th Annual Meeting of the American Gastroenterological Association
    • Place of Presentation
      米国 サンディェゴ
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of a New Mouse Model of Fatal Autoimmune Hepatitis2008

    • Author(s)
      Norihiko Watanabe, et al
    • Organizer
      109th Annual Meeting of the American Gastroenterological Association
    • Place of Presentation
      米国 サンディェゴ
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] The role of innate immunity in the pathogenesis of murine autoimmune pancreatitis2007

    • Author(s)
      Akiyoshi Nishio
    • Organizer
      15th United European Gastroenterology Week
    • Place of Presentation
      フランス パリ
    • Year and Date
      2007-10-30
    • Related Report
      2008 Final Research Report
  • [Presentation] The role of innate immunity in the pathogenesis of murineautoimmune pancreatitis2007

    • Author(s)
      Akiyoshi Nishio
    • Organizer
      15th United European Gastroenterology Week
    • Place of Presentation
      フランス パリ
    • Year and Date
      2007-10-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Interleukin 10 is essential for prevention of murine autoimmune pancreatitis induced by poly I:C administration2007

    • Author(s)
      Akiyoshi Nishio
    • Organizer
      108th Annual Meeting of the American Gastroenterological Association
    • Place of Presentation
      米国 ワシントン
    • Year and Date
      2007-05-19
    • Related Report
      2008 Final Research Report
  • [Presentation] The role of innate immunity in the pathogenesis of murine experimental model of autoimmune pancreatitis2007

    • Author(s)
      Masanori Asada
    • Organizer
      108th Annual Meeting of the American Gastroenterological Association
    • Place of Presentation
      米国 ワシントン
    • Year and Date
      2007-05-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Interleukin 10 is essential for prevention of murineautoimmune pancreatitis induced by poly I:C administration2007

    • Author(s)
      Akiyoshi Nishio
    • Organizer
      08th Annual Meeting of the Americn Gastroneterological Association
    • Place of Presentation
      米国 ワシントン
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] The role of innate immunity in the pathogenesis of murineexperimental model of autoimmune pancreatitis2007

    • Author(s)
      Masanori Asada
    • Organizer
      108th Annual Meeting of the Americn Gastroneterological Association
    • Place of Presentation
      米国 ワシントン
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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