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Analysis of activation of dendritic cells by γ-PGA nano-particle and liver cancer immunotherapy

Research Project

Project/Area Number 19590766
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionOsaka University

Principal Investigator

TATSUMI Tomohide  Osaka University, 医学系研究科, 助教 (20397699)

Co-Investigator(Kenkyū-buntansha) TAKEHARA Tetsuo  大阪大学, 医学系研究科, 准教授 (70335355)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsナノテクノロジー / 肝癌免疫治療 / 樹状細胞
Research Abstract

疎水化poly-γ-PGA ナノ粒子と癌抗原由来ペプチドを結合させ、これを用いたワクチンの有用性を検討した。マウス肝腫瘍系では本ワクチンにより、効率よく癌抗原特異的CTL が誘導され、肝腫瘍に対して抗腫瘍効果を認めた。また本治療法は肝障害・腎障害を認めず安全であった。ヒト樹状細胞もγ-PGA ナノ粒子を使うことで活性化が起こった。以上の結果からγ-PGA ナノ粒子-ペプチドワクチンによる新たな肝癌免疫治療の可能性が示された

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (88 results)

All 2008 2007

All Journal Article (25 results) (of which Peer Reviewed: 25 results) Presentation (63 results)

  • [Journal Article] Mutationsassociated with therapeutic efficacyof Adefovir dipivoxil added toLamivudine-resistant chronichepatitis B2008

    • Author(s)
      Ohkawa K, Takehara T(2番目), Tatsumi T(15番目), (他13名))
    • Journal Title

      J. Med. Virol (In press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased expressions ofCD1d molecule on liver dendritic cellsin subcutaneous tumor bearing mice2008

    • Author(s)
      Tatsumi T(1番目), Takehara T(2番目), (他7名)
    • Journal Title

      J. Hepatol 49

      Pages: 779-786

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dendritic cell-based vaccines suppress livertumor via activation of innate and acquired immunity2008

    • Author(s)
      Yamaguchi S, Tatsumi T(2番目), Takehara T(3番目), (他7名)
    • Journal Title

      Cancer Immunol. Immunother 57

      Pages: 1861-1869

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Supportive roleplayed by Precore and PreS2 genomic changes in establishment of Lamivudine-Resitant Hepatitis B virus2008

    • Author(s)
      Ohkawa K, Takehara T(2番目), Tatsumi T(14番名), (他12名)
    • Journal Title

      J. Infect. Dis 198

      Pages: 1150-1158

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum levels ofsoluble major histocompatibilitycomplex (MHC) class I-related chain Ain patients with chronic liverdiseases and changes duringtranscatheter arterial embolizationfor hepatocellular carcinoma2008

    • Author(s)
      Kohga K, Takehara T(2番目), TatsumiT(3番目), (他8名)
    • Journal Title

      Cancer Sci 99

      Pages: 1643-1649

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early emergence ofentecavir-resistant hepatitis B virusin a patient with hepatitis Bvirus/human immunodeficiency viruscoinfection2008

    • Author(s)
      Kanada A, Takehara T(2番目)Tatsumi T(5番目), (他13名)
    • Journal Title

      Heptol. Res 35

      Pages: 622-628

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activated liverdendritic cells generates strongacquired immunity inα-galactosylceramide treatment2008

    • Author(s)
      Sasakawa A, Tatsumi T(2番目), Takehara T(3番目), (他5名)
    • Journal Title

      J. Hepatol (In press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dendritic cell-based vaccines suppress liver tumor via activation of in nate and acquired immunity2008

    • Author(s)
      Yamaguchi S, Tatsumi T, et al.
    • Journal Title

      Cancer Immunology, Immunotherapy 57

      Pages: 1861-8169

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum levels of soluble major histocompatibility complex (MHC)class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma2008

    • Author(s)
      Kohga K, Tatsumi T, et al.
    • Journal Title

      Cancer Science 99

      Pages: 1643-1649

    • NAID

      10024010054

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased expressions of CD1d molecule on liver dendritic cells in subcutaneous tumor bearing mice2008

    • Author(s)
      Tatsumi T, et al.
    • Journal Title

      Journal of Hepatology 49

      Pages: 779-786

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early emergence of entecavir-resistant hepatitis B virus in a patient with hepatitis B virus/human immunodeficiency virus coinfection2008

    • Author(s)
      Kanada A, Tatsumi T, et al.
    • Journal Title

      Hepatology Research 38

      Pages: 622-628

    • NAID

      10024149003

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Supportive role played by Precore and PreS2 genomic changes in establishment of Lamivudine-Resitant Hepatitis B virus2008

    • Author(s)
      Ohkawa K, Tatsumi T, et al
    • Journal Title

      The Journal of Infectious Diseases 198

      Pages: 1150-1158

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutations associated with therapeutic efficacy of Adefovir dipivoxil added to Lamivudine-resistant chronic hepatitis B2008

    • Author(s)
      Ohkawa K, Tatsumi T, et al.
    • Journal Title

      Journal of Medical Virology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activated liver dendritic cells generates strong acquired immunity in a-galactosylceramide treatment2008

    • Author(s)
      Sasakawa A, Tatsumi T, et al.
    • Journal Title

      Journal of Hepatology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrahepatic delivery ofα-galatosylceramide pulsed dendriticcells suppresses liver tumor2007

    • Author(s)
      Tatsumi T(1番目), Takehara T(2番目), (他7名)
    • Journal Title

      Hepatology 45

      Pages: 22-30

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Injection of IL-12gene-transduced dendritic cells intomouse liver tumor lesions activatesboth innate and acquired immunity2007

    • Author(s)
      Tatsumi T(1番目), Takehara T(2番目), ( 他10名)
    • Journal Title

      Gene Ther 14

      Pages: 863-871

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunotherapy ofmurine colon cancer using receptortyrosine kinase EphA2 derivedpeptide-pulsed dendritic cellvaccines2007

    • Author(s)
      Yamaguchi, Tatsumi T(2番目), Takehara T(3番目), (他7名)
    • Journal Title

      Cancer 110

      Pages: 1469-1477

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Signal Transducerand Activator of Transcription 3signaling within hepatocytesattenuates systemic inflammatoryresponse and lethality in septic mice2007

    • Author(s)
      Sakamori R, Takehara T(2番目), Tatsumi T(4番目), (他5名)
    • Journal Title

      Hepatology 46

      Pages: 1564-1573

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natural killercell-mediated ablation of metastaticliver tumors by hydrodynamic injectionof IFN alpha gene to mice2007

    • Author(s)
      Takehara T(1番目), Tatsumi T(3番目), ( 他8名)
    • Journal Title

      Int. J. Cancer 120

      Pages: 1252-1260

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natural Killer celland hepatic cell interaction via NKG2Aleads to dendritic cell-mediatedinduction of CD4+CD25+ T cells with PD-1-dependent regulatory activities2007

    • Author(s)
      Jinushi M, Takehara T(2番目), Tatsumi T(3番目), (他6名)
    • Journal Title

      Immunology 120

      Pages: 73-82

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Type B fulminanthepatitis is closely associated witha highly mutated hepatitis B virusstrain2007

    • Author(s)
      Kanada A, Takehara T(2番目), Tatsumi T(4番目), (他14名)
    • Journal Title

      Intervirology 50

      Pages: 294-401

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Injection of IL-12 gene-transduced dendritic cells into mouse liver tumor lesions activates both innate and acquired immunity2007

    • Author(s)
      Tatsumi T, et. al.
    • Journal Title

      Gene Therapy 14

      Pages: 863-871

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Signal Transducer and Activator of Transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice2007

    • Author(s)
      Sakamori R, Tatsumi T, et. al.
    • Journal Title

      Hepatology 46

      Pages: 1564-1573

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunotherapy of murine colon cancer using receptor tyrosine kinase EphA2 derived peptide-pulsed dendritic cell vaccines2007

    • Author(s)
      Yamaguchi S, Tatsumi T, et. al.
    • Journal Title

      Cancer 110

      Pages: 1469-1477

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type B fulminant hepatitis is closely associated with a highly mutated hepatitis B virus strain2007

    • Author(s)
      Kanada A, Tatsumi T, et. al.
    • Journal Title

      Intervirology 50

      Pages: 394-401

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] SN38 inhibits the shedding ofMHC class1-related chain A, a ligandof NKG2D immunoreceptor in humanhepatocellular carcinoma cells2008

    • Author(s)
      Kohga K, Takehara T, Tatsumi T, (他14名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-04
    • Related Report
      2008 Final Research Report
  • [Presentation] SN38 inhibits the shedding of MHC class1-related chain A, a ligand of NKG2D immunoreceptor in human hepatocellular carcinoma cells.2008

    • Author(s)
      甲賀啓介, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Activated liver dendritic cellsare more immunogenic than spleendendritic cells after α-GalCertreatment2008

    • Author(s)
      Sasakawa A, Tatsumi T, Takehara T, (他11名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Efficacy of theimmunotherapy with γ-polyglutamicacid nanoparticles in mouse livertumor2008

    • Author(s)
      Yamaguchi S, Tatsumi T, Takehara T, ( 他14名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Critical role of IFNγ producedfrom NK cells in IL-12-mediated NKcell activation and anti-tumor effectin the liver2008

    • Author(s)
      Uemura A, Takehara T, Tatsumi T, (他14名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Expression of NKG2D activatingreceptor on natural killer cells inchronic hepatitis C.2008

    • Author(s)
      Shimizu S, Takehara T, Tatsumi T, (他14名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Extended treatment withpeginterferon alfa-2b and ribavirincombination therapy can suppress therelapse rate after treatment ofchronic hepatitis C genotype 1patients with late viral response2008

    • Author(s)
      Oze T, Tatsumi T, Takehara T, (他28名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Ribavirin dose reduction raisesrelapse rate dose-dependently ingenotype 1 patients with chronichepatitis C responding to pegylatedinterferon alfa-2b plus ribavirin2008

    • Author(s)
      Oze T, Tatsumi T, Takehara T, (他26名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Activated liver dendritic cells are more immunogenic than spleen dendritic cells after α-GalCer treatment.2008

    • Author(s)
      笹川 哲, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Efficacy of the immunotherapy with γ-polyglutamic acid nanoparticles in mouse liver tumor.2008

    • Author(s)
      山口真二郎, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Critical role of IFNγ produced from NK cells in IL-12-mediated NK cell activation and anti-tumor effect in the liver.2008

    • Author(s)
      植村彰夫, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Expression of NKG2D activating receptor on natural killer cells in chronic hepatitis C.2008

    • Author(s)
      清水 聡, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Extended treatment with peginterferon alfa-2b and ribavirin combination therapy can suppress the relapse rate after treatment of chronic hepatitis C genotype 1 patients with late viral response.2008

    • Author(s)
      小瀬嗣子, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ribavirin dose reduction raises relapse rate dose-dependently in genotype 1 patients with chronic hepatitis C responding to pegylated interferon alfa-2b plus ribavirin.2008

    • Author(s)
      小瀬嗣子, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Supportive activity of PreCoreand PreS2 viral genomic changesagainst replication ofLamivudine-resistant hepatitis Bvirus2008

    • Author(s)
      Ohkawa K, Takehara T, Tatsumi T, (他9名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Supportive activity of PreCore and PreS2 viral genomic changes against replication of Lamivudine-resistant hepatitis B virus.2008

    • Author(s)
      大川和良, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] BH3-only protein Bid isrequired for hepatocyte apoptosiscaused by Bcl-xL deficiency2008

    • Author(s)
      Hikita H, Takehara T, Tatsumi T, (他10名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-01
    • Related Report
      2008 Final Research Report
  • [Presentation] BH3-only protein Bid is required for hepatocyte apoptosis caused by Bcl-xL deficiency.2008

    • Author(s)
      疋田隼人, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 難治性C 型肝炎に対するPeg-IFN/Ribavirin 長期投与の有用性について-多施設(OLF)共同研究-2008

    • Author(s)
      小瀬嗣子、竹原徹郎、巽智秀、(他17名)
    • Organizer
      第12回肝臓学会大会
    • Place of Presentation
      東京都港区
    • Year and Date
      2008-10-01
    • Related Report
      2008 Final Research Report
  • [Presentation] 難治性C型肝炎に対するPeg-IFN/Ribavirin長期投与の有用性について-多施設(OLF)共同研究-2008

    • Author(s)
      小瀬嗣子, 巽 智秀, 他
    • Organizer
      第12回日本肝臓学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肝先天免疫活性化による肝樹状細胞活性化機構の解析2008

    • Author(s)
      笹川 哲、巽智秀、竹原徹郎、(他11名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-06
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] BcL-xL は生体内肝細胞におけるBid の恒常的活性化によるアポトーシスを抑制する2008

    • Author(s)
      疋田隼人、竹原徹郎、巽智秀、(他13名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-06
    • Related Report
      2008 Final Research Report
  • [Presentation] 難治性C 型肝炎に対するPeg-IFN/Ribavirin 併用療法でのEVR 例における薬剤adherence の影響-多施設(OLF)共同研究-2008

    • Author(s)
      小瀬嗣子、竹原徹郎、巽智秀、(他18名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-06
    • Related Report
      2008 Final Research Report
  • [Presentation] ウイルス感染モデルを用いたインターフェロンの免疫細胞内におけるシグナル伝達機構の制御メカニズムに関する基礎的検討2008

    • Author(s)
      宮城琢也、竹原徹郎、巽智秀、(他2名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-06
    • Related Report
      2008 Final Research Report
  • [Presentation] BcL-xLは生体内肝細胞におけるBidの恒常的活性化によるアポトーシスを抑制する2008

    • Author(s)
      疋田隼人, 巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 難治性C型肝炎に対するPeg-IFN/Ribavirin併用療法でのEVR例における薬剤adherenceの影響-多施設(OLF)共同研究-2008

    • Author(s)
      小瀬嗣子, 巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] ウイルス感染モデルを用いたインターフェロンの免疫細胞内におけるシグナル伝達機構の抑制メカニズムに関する基礎的検討2008

    • Author(s)
      宮城琢也, 巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 皮下腫瘍担癌マウスにおける肝樹状細胞上CD1d 分子発現低下による肝先天免疫の抑制2008

    • Author(s)
      巽智秀、竹原徹郎、(他13名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Related Report
      2008 Final Research Report
  • [Presentation] SN38 は肝癌細胞の可溶性NK 活性リガンドの分泌を抑制しNK 細胞感受性を増強させる2008

    • Author(s)
      甲賀啓介、竹原徹郎、巽智秀、(他11名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Related Report
      2008 Final Research Report
  • [Presentation] IL-12 遺伝子による肝臓NK 細胞の活性化および転移性肝腫瘍治療効果にはリンパ球からのIFN-γ産生が重要である2008

    • Author(s)
      植村彰夫、竹原徹郎、巽智秀、(他11名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Related Report
      2008 Final Research Report
  • [Presentation] ラミブジン耐性B 型肝炎ウイルス成立機転に対するprecore ならびにpreS2 変異の補助的役割2008

    • Author(s)
      大川和良、竹原徹郎、巽智秀、(他12名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Peg-IFN/Ribavirin 併用療法における高感度HCV-RNA 測定法(TaqMan 法)の有用性について2008

    • Author(s)
      小瀬嗣子、竹原徹郎、巽智秀、(他12名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Related Report
      2008 Final Research Report
  • [Presentation] 皮下腫瘍担癌マウスにおける肝樹状細胞上CD1d分子発現低下による肝先天免疫の抑制2008

    • Author(s)
      巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] SN38は肝癌細胞の可溶性NK活性リガンドの分泌を抑制しNK細胞感受性を増強させる2008

    • Author(s)
      甲賀啓介, 巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] IL-12遺伝子による肝臓NK細胞の活性化および転移性肝腫瘍治療効果にはリンパ球からの IFN-γ産生が重要である2008

    • Author(s)
      植村彰夫, 巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラミブジン耐性B型肝炎ウイルス成立機転に対するprecoreならびにpreS2変異の補助的役割2008

    • Author(s)
      大川和良, 巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Peg-IFN/Ribavirin併用療法における高感度HCV-RNA測定法(TaqMan法)の有用性について2008

    • Author(s)
      小瀬嗣子, 巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulation of the NKG2D immunoreceptor by soluble MICA during transcatheter arterial embolizationfor hepatocellular carcinoma.2007

    • Author(s)
      Kohga K, Takehara T, Tatsumi T, (他11名)
    • Organizer
      第58回米国肝臓学会
    • Place of Presentation
      米国ボストン
    • Year and Date
      2007-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Regulation of the NKG2D immunoreceptor by soluble MICA during transcatheter arterial embolization for hepatocellular carcinoma2007

    • Author(s)
      甲賀啓介、巽 智秀、他
    • Organizer
      第58回アメリカ肝臓学会総会
    • Place of Presentation
      米国ボストン
    • Year and Date
      2007-11-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Dynamic regulation of the NKG2D immunoreceptor expression by soluble MICA during TAE for hepatocellular carcinoma2007

    • Author(s)
      甲賀啓介、竹原徹郎、巽智秀、 (他7名)
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-10-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Soluble forms of human NKG2D ligands MICA/B increase in sera of patients with liver cirrhosis and HCC2007

    • Author(s)
      疋田隼人、竹原徹郎、巽智秀、 (他7名)
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-10-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Administration of α-galactosylceramide induces liver acquired immunity after liver tumor rejection2007

    • Author(s)
      巽智秀、竹原徹郎、(他8名)
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-10-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Administration of α-galactosylceramide induces liver acquired immunity after liver tumor rejection2007

    • Author(s)
      巽 智秀、他
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Dynamic regulation of the NKG2D immunoreceptor expression by soluble MICA during TAE for hepatocellular carcinoma2007

    • Author(s)
      甲賀啓介、巽 智秀、他
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Immunotherapy of murine colon cancer using receptor tyrosine kinase EphA2 derived peptide-pulsed dendritie cell vaccines2007

    • Author(s)
      山口真二郎、巽智秀、竹原徹郎、(他8名)
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Immunotherapy of murine colon cancer using receptor tyrosine kinase EnhA2 derived peptide-pulsed dendritic cell vaccines2007

    • Author(s)
      山口真二郎、巽 智秀、他
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Activation of liver dendritic cells by administration of α-galactosylceramide.2007

    • Author(s)
      笹川 哲、巽智秀、竹原徹郎、(他5名)
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Dendritic cell-based vaccines suppress liver tumor viaactivation of innate and acquired immunity2007

    • Author(s)
      阪森亮太郎、巽智秀、竹原徹郎、( 他8名)
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Dendritic cell-based vaccines suppress liver tumor via activation of innate and acquired immunity2007

    • Author(s)
      阪森亮太郎、巽 智秀、他
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Activation of liver dendritic cells by administration of α-galactosyl ceramide2007

    • Author(s)
      笹川 哲、巽 智秀、他
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 肝臓におけるSTAT3 の活性化は敗血症時のTNF-αの産生を抑制し生存率を向上させる2007

    • Author(s)
      阪森亮太郎、竹原徹郎、巽智秀、(他6名)
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京都港区
    • Year and Date
      2007-06-01
    • Related Report
      2008 Final Research Report
  • [Presentation] NKT細胞活性化を介した肝癌特異的獲得免疫の誘導2007

    • Author(s)
      巽智秀、竹原徹郎、(他11名)
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京都港区
    • Year and Date
      2007-06-01
    • Related Report
      2008 Final Research Report
  • [Presentation] 肝腫瘍に対する新規癌抗原EphA2 を用いたDC ワクチン療法の基礎的検討2007

    • Author(s)
      山口真二郎、巽智秀、竹原徹郎、(他8名)
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京都港区
    • Year and Date
      2007-06-01
    • Related Report
      2008 Final Research Report
  • [Presentation] NKT細胞活性化を介した肝癌特異的獲得免疫の誘導2007

    • Author(s)
      巽 智秀、他
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] 肝腫瘍に対する新規癌抗原EphA2を用いたDCワクチン療法の基礎的検討2007

    • Author(s)
      山口真二郎、巽 智秀、他
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] 肝臓におけるSTAT3の活性化は敗血症時のTNF-αの賛成を抑制し生存率を向上させる2007

    • Author(s)
      阪森亮太郎、巽智秀、他
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] α-galactosylceramide による肝樹状細胞活性化機構の解析2007

    • Author(s)
      笹川哲、竹原徹郎、巽智秀、(他9名)
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京都港区
    • Year and Date
      2007-05-31
    • Related Report
      2008 Final Research Report
  • [Presentation] α-galatosylceramideによる肝樹状細胞活性化機構の解析2007

    • Author(s)
      笹川 哲、巽 智秀、他
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] 樹状細胞投与による肝先天免疫の活性化と予防的肝癌免疫治療の検討2007

    • Author(s)
      山口真二郎、巽智秀、竹原徹郎、(他9名)
    • Organizer
      第93回消化器病学会総会
    • Place of Presentation
      青森県青森市
    • Year and Date
      2007-04-20
    • Related Report
      2008 Final Research Report
  • [Presentation] 樹状細胞投与による肝先天免疫の活性化と予防的肝癌免疫治療の検討2007

    • Author(s)
      山口真二郎、巽 智秀、他
    • Organizer
      第93回消化器病学会総会
    • Place of Presentation
      青森
    • Year and Date
      2007-04-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] IFN γ is critically required for IL12-mediated NK cell activation and anti-tumor effect in the liver2007

    • Author(s)
      Uemura A, Takehara T, Tatsumi T, ( 他10名)
    • Organizer
      第58回米国肝臓学会
    • Place of Presentation
      米国ボストン
    • Related Report
      2008 Final Research Report
  • [Presentation] Impact of reducing peginterferon alfa-2b and ribavirin on early viral response in genotype 1 infected patients with chronichepatitis C2007

    • Author(s)
      Oze T, Takehara T, Tatsumi T, (他22名)
    • Organizer
      第58回米国肝臓学会
    • Place of Presentation
      米国ボストン
    • Related Report
      2008 Final Research Report
  • [Presentation] Hepatic STAT3 attenuates systemic inflammatory response and lethality in septic mice.2007

    • Author(s)
      Sakamori R, Takehara T, Tatsumi T, (他7名)
    • Organizer
      第58回米国肝臓学会
    • Place of Presentation
      米国ボストン
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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