• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Research about the key molecule to contribute for hepatitis C virus elimination from the aspect of liver host cell and immune cells

Research Project

Project/Area Number 19590771
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionEhime University

Principal Investigator

HIASA Yoichi  Ehime University, 医学部附属病院, 講師 (70314961)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsC型肝炎ウイルス / インターフェロン / インターフェロン誘導遺伝子 / リバビリン末梢血リンパ球 / 内因性IFN-β / PKR / MxA / リバビリン / 末梢血リンパ球 / 複製モデル / 末梢血T細胞 / 2'5'-OAS
Research Abstract

C型肝炎ウイルス(HCV)は慢性持続感染し、インターフェロン(IFN)、リバビリン(RBV)がその治療に用いられている。本研究ではHCV排除に関わる宿主細胞因子を、培養肝細胞によるHCV複製系、および患者末梢血リンパ球を用いて、肝細胞、免疫細胞の両面から検討した。その結果、IFNによるHCV排除に、IFN誘導遺伝子(ISG)とりわけPKRが重要な因子であることが同定された。またRBVは肝細胞内因性IFN-β誘導作用を有し、IFNによって誘導されたISGをさらに増強し、この作用はRBVの臨床的治療効果に合致するものと考えられた。さらにRBVのような内因性IFN-β誘導能を持つ新たな抗HCV薬は、IFNとの併用により相乗的な抗HCV効果を発揮する可能性があり、今後のHCVに対する創薬のヒントとなると考えられた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (43 results)

All 2009 2008 2007

All Journal Article (30 results) (of which Peer Reviewed: 30 results) Presentation (10 results) Book (3 results)

  • [Journal Article] Hepatitis C virus replication is inhibited by 22β-methoxyolean-12-ene -3β, 24(4β)-diol(ME3738) through enhancing IFN-β2008

    • Author(s)
      Hiasa Y, Kuzuhara H, Tokumoto Y(他6名, 1番目)
    • Journal Title

      Hepatology 72巻

      Pages: 867-872

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuropsychiatric dysfunction in patients with chronic hepatitis and liver cirrhosis2008

    • Author(s)
      Michitaka K, Tokumoto Y, Hiasa Y(他10名, 9番目)
    • Journal Title

      Hepatology Research 38巻

      Pages: 1069-1075

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wilms' tumor 1 gene expression is increased in hepatocellular carcinoma and associated with poor prognosis2008

    • Author(s)
      Sera T, Hiasa Y, Mashiba T(他7名, 2番目)
    • Journal Title

      European Journal of Cancer 44巻

      Pages: 600-608

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired dendritic cell functions because of depletion of natural killer cells disrupt antigen-specific immune responses in mice2008

    • Author(s)
      Yoshida O, Akbar F, Hiasa Y(他4名, 6番目)
    • Journal Title

      Clinical Experimental Immunology 152巻

      Pages: 174-181

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver/spleen volume ratio as a predictor of prognosis in primary biliary cirrhosis2008

    • Author(s)
      Murata Y, Abe M, Hiasa Y(他7名, 3番目)
    • Journal Title

      Journal of Gastroenterology 43巻

      Pages: 632-636

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of splenectomy for hypersplenic patients with advanced hepatocellular carcinoma2008

    • Author(s)
      Hirooka M, Ishida K, Hiasa Y(他5名, 6番目)
    • Journal Title

      Hepatology Research 38巻

      Pages: 1172-1177

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristic endoscopic features of portal hypertensive enteropathy2008

    • Author(s)
      Higaki N, Matsui H, Hiasa Y(他5名, 6番目)
    • Journal Title

      Journal of Gastroenterology 43巻

      Pages: 327-331

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective role of interleukin-10-producing regulatory dendritic cells against murine autoimmune dendritic cells against murine autoimmune2008

    • Author(s)
      Torisu M, Murakami H, Akbar F, Hiasa Y(他4名, 5番目)
    • Journal Title

      Journal of Gastroenterology 43巻

      Pages: 100-107

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutational analysis of predicted intracellular loop domains of human motilin receptor2008

    • Author(s)
      Tokunaga H, Matsuura B, Hiasa Y(他5名, 7番目)
    • Journal Title

      American Journal of Physiology Gastrointestinal and Liver Physiology 294巻

      Pages: 460-466

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus replication is inhibited by 22β-methoxyolean-12-ene-3β, 24(4β)-diol (ME3738) through enhancing IFN-β2008

    • Author(s)
      Hiasa Y, Kuzuhara H, Tokumoto Y, (他6名, 1番目)
    • Journal Title

      Hepatology 72

      Pages: 867-872

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired dendritic cell functions because of depletion of natural killer cells disrupt antigen-specific immune responses in mice2008

    • Author(s)
      Yoshida O, Akbar F, Hiasa Y, (他4名, 6番目)
    • Journal Title

      Clinical Experimental Immunology 152

      Pages: 174-181

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutational analysis of predicted intracellular loop domains of human motilin receptor2008

    • Author(s)
      Tokunaga H, Matsuura B, Hiasa Y, (他5名, 7番目)
    • Journal Title

      American Journal of Physiology Gastrointestinal and Liver Physiology 294

      Pages: 460-466

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wilms' tumour 1 gene expression is increased in hepatocellular carcinoma and associated with poor prognosis2008

    • Author(s)
      Sera T, Hiasa Y, Mashiba T, Tokumoto Y, Hirooka M, et. al.
    • Journal Title

      European Journal of Cancer 44

      Pages: 600-608

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Engineering immune therapy against hepatitis B virus2007

    • Author(s)
      Akbar F, Yoshida O, Hiasa Y(他2名, 4番目)
    • Journal Title

      Hepatology Research 37巻

      Pages: 351-356

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus expression and interferon antiviral action is dependent on PKR expression2007

    • Author(s)
      Tokumoto Y, Hiasa Y, Horiike N(他4名, 2番目)
    • Journal Title

      Journal of Medical Virology 79巻

      Pages: 1120-1127

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of lamivudine-resistant hepatitis B virus(HBV) strains with and without breakthrough hepatitis in patients with chronic hepatitis B evaluated by serial HBV full-genome sequences2007

    • Author(s)
      Horiike N, Duong TN, Hiasa Y(他5名, 5番目)
    • Journal Title

      Journal of Medical Virology 79巻

      Pages: 911-918

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Compartmentalization of hepatitis C virus(HCV) during HCV/HIV coinfection2007

    • Author(s)
      Blackard JT, Hiasa Y, Smeaton L(他4名, 2番目)
    • Journal Title

      Journal of Infectious Disease 195巻

      Pages: 1765-1773

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired dendritic cell function resulting from chronic undernutrition disrupts the antigen-specific immune response in mice2007

    • Author(s)
      Niiya T, Akbar SMF, Hiasa Y(他6名, 8番目)
    • Journal Title

      Journal of Nutrition 137巻

      Pages: 671-675

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine2007

    • Author(s)
      Mashiba T, Udaka K, Hiasa Y(他7名, 4番目)
    • Journal Title

      Immunogenetics 59巻

      Pages: 197-209

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of anti-HBs in HB vaccine nonresponders in vivo by hepatitis B surface antigen-pulsed blood dendritic cells2007

    • Author(s)
      Akbar SMF, Furukawa S, Hiasa Y(他3名, 4番目)
    • Journal Title

      Journal of Hepatology 47巻

      Pages: 60-66

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Percutaneous ultrasound-guided radiofrequency ablation of hepatocellular carcinoma with artificially induced pleural effusion and ascites2007

    • Author(s)
      Uehara T, Hirooka M, Hiasa Y(他5名, 3番目)
    • Journal Title

      Journal of Gastroenterology 42巻

      Pages: 306-311

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recurrence of autoimmune hepatitis after liver transplantation without elevation of alanine aminotransferase2007

    • Author(s)
      Yao H, Michitaka K, Hiasa Y(他6名, 7番目)
    • Journal Title

      World Journal of Gastroenterology 13巻

      Pages: 1618-1621

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diabetes mellitus reduces the therapeutic effectiveness of interferon-alpha2b plus ribavirin therapy in patients with chronic hepatitis C2007

    • Author(s)
      Konishi I, Horiike N, Hiasa Y(他8名, 3番目)
    • Journal Title

      Hepatology Research 37巻

      Pages: 331-336

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of geographic distributions and route of infection for hepatitis B virus genotype D in Ehime area in western Japan2007

    • Author(s)
      Matsuura K, Michitaka K, Hiasa Y(他6名, 7番目)
    • Journal Title

      Hepatology Research 37巻

      Pages: 255-262

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of hepatitis E virus among wild boar in the Ehime area of western Japan2007

    • Author(s)
      Michitaka K, Takahashi K, Hiasa Y(他6名, 5番目)
    • Journal Title

      Hepatology Research 37巻

      Pages: 214-220

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of laparoscopic splenectomy in patients with hypersplenism2007

    • Author(s)
      Watanabe Y, Horiuchi A, Hiasa Y(他5名, 7番目)
    • Journal Title

      World Journal of Surgery 31巻

      Pages: 549-555

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity of hepatitis B virus genotype D in Japan2007

    • Author(s)
      Michitaka K, Horiike N, Hiasa Y(他8名, 10番目)
    • Journal Title

      Intervirology 50巻

      Pages: 150-155

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary habits and nutrient intake in non-alcoholic steatohepatitis2007

    • Author(s)
      Toshimitsu K, Matsuura B, Hiasa Y(他6名, 6番目)
    • Journal Title

      Nutrition 23巻

      Pages: 46-52

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus expression and interferon antiviral action is dependent on PKR expression2007

    • Author(s)
      Tokumoto Y, Hiasa Y, Horiike N, Michitaka K, et. al.
    • Journal Title

      Journal of Medical Virology 79

      Pages: 1120-1127

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compartmentalization of hepatitis C virus (HCV) during HCV/HIV coinfection2007

    • Author(s)
      Blackard JT, Hiasa Y, Smeaton L, Jamieson DJ, et. al.
    • Journal Title

      Journal of Infectious Disease 195

      Pages: 1765-1773

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] The enhancement of autocrine interferon-beta and the decrease of SOCS-3 by ME3738 would contribute the synergistic anti-HCV effects combined with interferon-alpha2008

    • Author(s)
      Hiasa Y, Tokumoto Y, Konishi I(他2名, 1番目)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2008-11-04
    • Related Report
      2008 Final Research Report
  • [Presentation] The enhancement of autocrine interferon-beta and the decrease of SOCS-3 by ME3738 would contribute the synergistic anti-HCV effects combined with interferon-alpha2008

    • Author(s)
      Hiasa Y, Tokumoto Y, Konishi I, (他2名, 1番目).
    • Organizer
      The 59^<th> Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2008-11-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ribavirin upregulates autocrine interferon-β and interferon stimulated genes in the early phase of the combination treatment with interferon-α2008

    • Author(s)
      Tokumoto Y, Hiasa Y, Konishi I(他4名, 2番目)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2008-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] HepG2細胞におけるME3738による内因性IFN-βの増加とその抗HCV 効果2008

    • Author(s)
      日浅陽一、徳本良雄、小西一郎(他2名, 1番目)
    • Organizer
      第50回日本消化器病学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-01
    • Related Report
      2008 Final Research Report
  • [Presentation] リバビリンによるインターフェロン誘導遺伝子の修飾と治療効果への役割2008

    • Author(s)
      徳本良雄、日浅陽一、恩地森一
    • Organizer
      第44回日本肝臓学会総会
    • Place of Presentation
      松山
    • Year and Date
      2008-06-05
    • Related Report
      2008 Final Research Report
  • [Presentation] 高齢者(65歳以上)のC型慢性肝炎患者における抗ウイルス治療効果2007

    • Author(s)
      日浅陽一、小西一郎、世良俊樹(他4名, 1番目)
    • Organizer
      第37回日本肝臓学会西部会
    • Place of Presentation
      長崎
    • Year and Date
      2007-12-08
    • Related Report
      2008 Final Research Report
  • [Presentation] ME3738 inhibits hepatitis C virus replication by enhancing interferon-beta2007

    • Author(s)
      Hiasa Y, Tokumoto Y, Konishi I(他4名, 1番目)
    • Organizer
      第58回米国肝臓学会
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2007-11-06
    • Related Report
      2008 Final Research Report
  • [Presentation] ME3738 inhibits hepatitis C virus replication by enhancing interferon-beta2007

    • Author(s)
      Hiasa Y, Tokumoto Y, Konishi I, Matsuura B, et. al.
    • Organizer
      The 58^<th> Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston,MA,USA
    • Year and Date
      2007-11-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] ME3738とインターフェロン併用による抗HCV効果の基礎的検討2007

    • Author(s)
      日浅陽一、徳本良雄、小西一郎(他5名, 1番目)
    • Organizer
      第11回日本肝臓学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2007-10-18
    • Related Report
      2008 Final Research Report
  • [Presentation] C型肝炎に対する免疫療法2007

    • Author(s)
      日浅陽一、眞柴寿枝、恩地森一
    • Organizer
      第43回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-31
    • Related Report
      2008 Final Research Report
  • [Book] インターフェロンを中心に合併症のある症例自己免疫性肝疾患. そこが知りたいC型肝炎のベスト治療2009

    • Author(s)
      日浅陽一、恩地森一
    • Publisher
      医学書院
    • Related Report
      2008 Final Research Report
  • [Book] HBc抗原特異的細胞傷害性T細胞を誘導しうるHBc抗原ワクチン療法の開発. 第10回学術集会記録集2008

    • Author(s)
      日浅陽一
    • Publisher
      Liver Forum in Kyoto
    • Related Report
      2008 Final Research Report
  • [Book] 合併症のある症例 自己免疫性肝疾患そこが知りたい C型肝炎のベスト治療 インターフェロンを中心に2008

    • Author(s)
      日浅陽一, 恩地森一(分担執筆)
    • Publisher
      医学書院
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi